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Association of IL-18 gene polymorphism (−137C) with arthritis manifestations in SLE: combined effect with IFN gamma gene polymorphism (+874A)

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Abstract

We analyzed the association between single nucleotide polymorphisms in IL-12 and IL-18 genes in disease susceptibility and severity of SLE in Thais. A weak association was observed between A allele of the IL-12 gene at the 3′ untranslated region in SLE patients with proteinuria (OR = 1.89, 95% CI = 1.05–3.40, P = 0.02, Pc = 0.06). In addition, we found a significant association between C allele of IL-18 (−137) with arthritis (OR = 6.88, 95% CI = 1.54–42.93, P = 0.003, Pc = 0.009). The presence of one C allele (C/C+C/G) was associated with significant OR of 8.72 (95% CI = 1.83–56.71, P = 0.001, Pc = 0.003). Interestingly, we found the combined effect between the G/C genotype of IL-18 (−137) and the A/A genotype of IFNG (+874) gene causing susceptibility of arthritis in SLE patients (OR = 13.22, 95% CI = 1.56–291.66, P = 0.004).

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Acknowledgements

This study was supported by the Human Genetics grant from the National Center for Genetic Engineering and Biotechnology (BIOTEC), Thailand, Lupus Research Unit, Chulalongkorn University and the Faculty of Science, Burapha University. The authors wish to thank all the patients for their cooperation.

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Authors and Affiliations

  1. Lupus Research Unit, Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Rama 4 Road, Bangkok, 10330, Thailand

    Nattiya Hirankarn & Jongkonnee Wongpiyabovorn

  2. Department of Medical Science, Faculty of Science, Burapha University, Chonburi, Thailand

    Marut Tangwattanachuleeporn

  3. Department of Medicine, Nopparat Rajathanee Hospital, Bangkok, Thailand

    Jeerapat Wongchinsri

  4. Lupus Research Unit, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand

    Yingyos Avihingsanon

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  1. Nattiya Hirankarn
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  2. Marut Tangwattanachuleeporn
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  3. Jongkonnee Wongpiyabovorn
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  4. Jeerapat Wongchinsri
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  5. Yingyos Avihingsanon
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Correspondence to Nattiya Hirankarn.

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Hirankarn, N., Tangwattanachuleeporn, M., Wongpiyabovorn, J. et al. Association of IL-18 gene polymorphism (−137C) with arthritis manifestations in SLE: combined effect with IFN gamma gene polymorphism (+874A). Clin Rheumatol 28, 219–223 (2009). https://doi.org/10.1007/s10067-008-1036-4

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  • DOI: https://doi.org/10.1007/s10067-008-1036-4

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