Abstract
Recent studies suggest that psoriasis is a systemic disorder associated with cardiovascular disease (CVD) risk factors, such as obesity, hypertension and dyslipidemia. However, these risk factors have not been widely recognized across different populations. This cross-sectional study aimed to examine the association of risk factors for CVD with psoriasis by comparing patients with psoriasis and matched controls in northern China. This study identified 291 patients with diagnosed moderate or severe psoriasis as cases and 445 age- and gender-matched subjects as controls. A significant association (P < 0.01) was observed between overall psoriasis incidence and smoking [odds ratio (OR), 2.96; 95 % confidence interval (CI) 2.09–4.09], alcohol consumption (OR, 3.77; 95 % CI 2.381–5.955), diabetes (OR, 2.79; 95 % CI 1.70–4.59), hypertension (OR, 2.19; 95 % CI 1.56–3.06) and hyperlipidemia (OR, 1.76; 95 % CI 1.29–2.40). Furthermore, hypertension correlated with the duration of psoriasis after adjustment for age and sex. Hyperlipidemia, smoking and alcohol consumption were related to the severity of the disease. Moreover, patients with psoriasis had lower levels of apolipoprotein B (ApoB) and lipoprotein (Lip) than did controls (P < 0.05). These data suggest that multiple risk factors for CVD are associated with psoriasis. CVD risk factor screening should be performed, and appropriate measures should be taken accordingly for psoriasis patients.
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References
Al-Mutairi N, Al-Farag S, Al-Mutairi A et al (2010) Comorbidities associated with psoriasis: an experience from the Middle East. J Dermatol 37:146–155
Altobelli E, Petrocelli R, Maccarone M et al (2009) Risk factors of hypertension, diabetes and obesity in Italian psoriasis patients: a survey on socio-demographic characteristics, smoking habits and alcohol consumption. Eur J Dermatol 19:252–256
Armstrong April W, Lin Steven W, Chambers Cynthia J et al (2011) Psoriasis and hypertension severity: results from a case–control study. PLoS ONE 29:e18227
Arsenault BJ, Després JP, Stroes ES et al (2010) Lipid assessment, metabolic syndrome and coronary heart disease risk. Eur J Clin Invest 40:1081–1093
Barter PJ, Ballantyne CM, Carmena R et al (2006) Apo B versus cholesterol in estimating cardiovascular risk and in guiding therapy: report of the thirty-person/ten-country panel. J Intern Med 259:247–258
Bonifati C, Mussi A, Carducci M (1998) Endothelin-1 levels are increased in sera and lesional skin extracts of psoriatic patients and correlate with disease severity. Acta Derm Venereol 78:22–26
Gunes Y, Tuncer M, Calka O et al (2008) Increased frequency of pulmonary hypertension in psoriasis patients. Arch Dermatol Res 300:435–440
Imafuku S, Nakayama J (2013) Profile of patients with psoriasis associated with hepatitis C virus infection. J Dermatol 40:428–433
Kuroda K, Sapadin A, Shoji T et al (2001) Altered expression of angiopoietins and Tie2 endothelium receptor in psoriasis. J Invest Dermatol 116(5):713–720
Langan SM, Seminara NM, Shin DB et al (2012) Prevalence of metabolic syndrome in patients with psoriasis: a population-based study in the United Kingdom. J Invest Dermatol 132:556–562
Mehta NN, Azfar RS, Shin DB et al (2010) Patients with severe psoriasis are at increased risk of cardiovascular mortality: cohort study using the General Practice Research Database. Eur Heart J 31:1000–1006
Mehta NN, Li R, Krishnamoorthy P et al (2012) Abnormal lipoprotein particles and cholesterol efflux capacity in patients with psoriasis. Atherosclerosis 224:218–221
Rautureau Y, Schiffrin EL (2012) Endothelin in hypertension: an update. Curr Opin Nephrol Hypertens 21:128–136
Shroff RC, Price KL, Kolatsi-Joannou M et al (2013) Circulating angiopoietin-2 is a marker for early cardiovascular disease in children on chronic dialysis. PLoS ONE 8(2):e56273
Siasos G, Tousoulis D, Oikonomou E et al (2011) Inflammatory markers in hyperlipidemia:from experimental models to clinical practice. Curr Pharm Des 17:4132–4146
Sierra-Johnson J, Fisher RM, Romero-Corral A et al (2009) Concentration of apolipoprotein B is comparable with the apolipoprotein B/apolipoprotein A-I ratio and better than routine clinical lipid measurements in predicting coronary heart disease mortality: findings from a multi-ethnic US population. Eur Heart J 30:710–717
Sommer DM, Jenisch S, Suchan M et al (2006) Increased prevalence of the metabolic syndrome in patients with moderate to severe psoriasis. Arch Dermatol Res 298:321–328
Tsai TF, Wang TS, Hung ST et al (2011) Epidemiology and comorbidities of psoriasis patients in a national database in Taiwan. J Dermatol Sci 63:40–46
Van Diepen JA, Berbée JF, Havekes LM et al (2013) Interactions between inflammation and lipid metabolism: relevance for efficacy of anti-inflammatory drugs in the treatment of atherosclerosis. Atherosclerosis 228:306–315
Xu T, Zhang YH (2012) Association of psoriasis with stroke and myocardial infarction: meta-analysis of cohort studies. Br J Dermatol 167:1345–1350
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This study has been supported in part by a grant from The Second Affiliated Hospital of Harbin Medical University and NSFC, China.
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M. Li and H. Wang contributed equally to this work.
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Ma, L., Li, M., Wang, H. et al. High prevalence of cardiovascular risk factors in patients with moderate or severe psoriasis in northern China. Arch Dermatol Res 306, 247–251 (2014). https://doi.org/10.1007/s00403-013-1437-3
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DOI: https://doi.org/10.1007/s00403-013-1437-3