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Metabolic syndrome and comorbidities in patients with psoriasis: a community-based case-control study from the Nagahama cohort in Japan

  • Clinical report
  • Published:
European Journal of Dermatology Aims and scope

Abstract

Background

Psoriasis is reported to be associated with systemic diseases, such as metabolic syndrome (MetS), which is related to high blood pressure, hyperglycaemia, obesity and dyslipidaemia. However, clinical factors associated with psoriasis in the general population have not been fully elucidated.

Objectives

To explore the clinical factors associated with psoriasis by analysing a dataset of community-based cohort studies

Materials & Methods

The study participants consisted of 9,183 apparently healthy community residents in Japan (mean age: 64.5 ± 10.7 years). The clinical parameters used in this study were obtained from a baseline investigation performed between 2008 and 2010. The history of psoriasis was queried using a structured questionnaire

Results

A total of 335 participants (3.6%) had a history of psoriasis. The psoriasis group was older (64.5 ± 10.7 vs 57.9 ± 12.3 years; p < 0.001) and mostly male (43.9 vs 33.0 %, p < 0.001) compared to the non-psoriasis group. Based on univariate analysis, the prevalence of MetS was higher in the psoriasis group (19.1 vs 13.6%, odds ratio = 1.50, p = 0.004), although this association disappeared after adjustment for age and sex. Similar results were observed based on the analysis of each MetS component. Other factors associated with psoriasis were history of tinea pedis (age-and sex-adjusted odds ratio = 5.27), gout (1.97), chronic obstructive pulmonary disease (5.83), reflux oesophagitis (1.72) and depressive symptoms (1.57). After further adjustment for potential covariates, the associations with these factors remained significant.

Conclusion

Several chronic conditions associated with psoriasis in the general population were identified

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Acknowledgements

the Nagahama Study Group Executive Committee is composed of the following individuals: Yasuharu Tabara, Takahisa Kawaguchi, Kazuya Setoh, Yoshimitsu Takahashi, Shinji Kosugi, Takeo Nakayama and Fumihiko Matsuda from the Centre for Genomic Medicine, Kyoto University Graduate School of Medicine (Ya.T, T.K., K.S., F.M.); Department of Health Informatics (Yo.T, T.N.); and the Department of Medical Ethics and Medical Genetics (S.K.), Kyoto University School of Public Health.

Funding

this study was supported by the following grants: University Grants and Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology in Japan; The Centre of Innovation Programme and the Global University Project from Japan Science and Technology Agency; and The Practical Research Project for Rare/Intractable Diseases and Comprehensive Research on Ageing and Health Science Research Grants for Dementia R&D from the Japan Agency for Medical Research and Development (AMED).

We are extremely grateful to the participants and citizens of Nagahama City, the Nagahama City Office and the nonprofit organisation Zeroji Club for their help in conducting the Nagahama study.

Author information

Authors and Affiliations

  1. Department of Dermatology, Kyoto University, Kyoto, Japan

    Yuichiro Endo & Kenji Kabashima

  2. St John’s Institute of Dermatology, School of Basic and Medical Biosciences, King’s College London, London, UK

    Yuichiro Endo, Alexandros Onoufriadis & John A. McGrath

  3. Center for Genomic Medicine, Kyoto University, Kyoto, Japan

    Yasuharu Tabara, Takahisa Kawaguchi & Fumihiko Matsuda

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  1. Yuichiro Endo
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Nagahama Study group

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Correspondence to Yuichiro Endo.

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Endo, Y., Tabara, Y., Kawaguchi, T. et al. Metabolic syndrome and comorbidities in patients with psoriasis: a community-based case-control study from the Nagahama cohort in Japan. Eur J Dermatol 32, 86–93 (2022). https://doi.org/10.1684/ejd.2022.4231

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  • DOI: https://doi.org/10.1684/ejd.2022.4231

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