Abstract
Introduction
Extracorporeal shock wave therapy (ESWT) may exert beneficial effects in avascular necrosis of femoral head (AVNFH).
Patients
The current study evaluated the effectiveness of ESWT in reducing pain and in slowing down the progression of bone damage in 36 patients with unilateral AVNFH of stage Association Research Circulation Osseous (ARCO) I, II and III. At the beginning of the study, 10 hips were classified as stage I, 11 as stage II and 15 as stage III. Each treatment cycle included four sessions, with 2,400 impulses each administered at 0.50 mJ/mm2, at 48–72 h intervals. Follow-up examinations were scheduled at 3, 6, 12 and then 24 months.
Method
Clinical assessments included assessment of pain scores, Harris Hip Scores and Roles and Maudsley score. Plain radiographs and magnetic resonances of the hip were used to evaluate the size of the lesion, the extent of collapse of subchondral bone, and degenerative changes of the hip joint.
Results
Patients from ARCO stage I group and stage II group achieved significantly better results than patients from ARCO stage III group at all follow-up time points (p < 0.005). During the follow-up period, 10 of the 15 stage III ARCO patients received an arthroplasty. ARCO stages I and II lesions were unchanged on radiographs and on magnetic resonance images.
Conclusion
ESWT in ARCO stages I and II may help to prevent progression of the area of avascular necrosis and manage pain.
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References
Chandler F (1948) Coronary disease of the hip. J Int Coll Surg 11:34–36
Mankin HJ (1992) Nontraumatic necrosis of bone (osteonecrosis). N Engl J Med 326(22):1473–1479
Assouline-Dayan Y, Chang C, Greenspan A, Shoenfeld Y, Gershwin ME (2002) Pathogenesis and natural history of osteonecrosis. Semin Arthritis Rheum 32(2):94–124
Malizos KN, Karantanas AH, Varitimidis SE, Dailiana ZH, Bargiotas K, Maris T (2007) Osteonecrosis of the femoral head: etiology, imaging and treatment. Eur J Radiol 63(1):16–28
Theodorou DJ, Malizos KN, Beris AE, Theodorou SJ, Soucacos PN (2001) Multimodal imaging quantitation of the lesion size in osteonecrosis of the femoral head. Clin Orthop Relat Res 386:54–63
Gardeniers JWM (1993) The ARCO perspective for reaching one uniform staging system of osteonecrosis. In: Scoutens A, Arlet J, Gardeniers JWM, Hughes SPF (eds) Bone circulation and vascularization in normal and pathologic conditions. Plenum, New York, pp 375–380
Steinberg ME, Hayken GD, Steinberg DR (1995) A quantitative system for staging avascular necrosis. J Bone Joint Surg Br 77(1):34–41
Wang CJ, Wang FS, Ko JY, Huang HY, Chen CJ, Sun YC, Yang YJ (2008) Extracorporeal shockwave therapy shows regeneration in hip necrosis. Rheumatology (Oxford) 47(4):542–546
Disch AC, Matziolis G, Perka C (2005) The management of necrosis-associated and idiopathic bone marrow edema of the proximal femur by intravenous iloprost. J Bone Joint Surg Br 87(4):560–564
Glueck CJ, Freiberg RA, Sieve L, Wang P (2005) Enoxaparin prevents progression of stages I and II osteonecrosis of the hip. Clin Orthop Relat Res 435:164–170
Lai KA, Shen WJ, Yang CY, Shao CJ, Hsu JT, Lin RM (2005) The use of alendronate to prevent early collapse of the femoral head in patients with nontraumatic osteonecrosis. A randomized clinical study. J Bone Joint Surg Am 87(10):2155–2159
Nishii T, Sugano N, Miki H, Hashimoto J, Yoshikawa H (2006) Does alendronate prevent collapse in osteonecrosis of the femoral head? Clin Orthop Relat Res 443:273–279
Massari L, Fini M, Cadossi R, Setti S, Traina GC (2006) Biophysical stimulation with pulsed electromagnetic fields in osteonecrosis of the femoral head. J Bone Joint Surg Am 88(Suppl 3):56–60
Hopper RA, VerHalen JP, Tepper O, Mehrara BJ, Detch R, Chang EI, Baharestani S, Simon BJ, Gurtner GC (2009) Osteoblasts stimulated with pulsed electromagnetic fields increase HUVEC proliferation via a VEGF—a independent mechanism. Bioelectromagnetics 30(3):189–197
Ma HZ, Zeng BF, Li XL (2007) Upregulation of VEGF in subchondral bone of necrotic femoral heads in rabbits with use of extracorporeal shock waves. Calcif Tissue Int 81(2):124–131
Ma HZ, Zeng BF, Li XL, Chai YM (2008) Temporal and spatial expression of BMP-2 in sub-chondral bone of necrotic femoral heads in rabbits by use of extracorporeal shock waves. Acta Orthop 79(1):98–105
Ludwig J, Lauber S, Lauber HJ, Dreisilker U, Raedel R, Hotzinger H (2001) High-energy shock wave treatment of femoral head necrosis in adults. Clin Orthop Relat Res 387:119–126
Russo S, Corrado EM, Corrado B et al (2004) The role of extracorporeal shock waves. In: Santori FS, Santori N, Piccinato A (eds) Avascular necrosis of the femoral head: current trends. Springer, Milan
Wang CJ, Wang FS, Huang CC, Yang KD, Weng LH, Huang HY (2005) Treatment for osteonecrosis of the femoral head: comparison of extracorporeal shock waves with core decompression and bone-grafting. J Bone Joint Surg Am 87:2380–2387
Wang CJ, Wang FS, Yang KD, Huang CC, Lee MS, Chan YS, Wang JW, Ko JY (2008) Treatment of osteonecrosis of the hip: comparison of extracorporeal shockwave with shockwave and alendronate. Arch Orthop Trauma Surg 128(9):901–908
Harris WH (1969) Traumatic arthritis of the hip after dislocation and acetabular fractures: treatment by mold arthroplasty: an end-result study using a new method of result evaluation. J Bone Joint Surg Am 51:737–755
Roles NC, Maudsley RH (1972) Radial tunnel syndrome: resistant tennis elbow as a nerve entrapment. J Bone Joint Surg Br 54:499–508
Ohzono K, Saito M, Sugano N, Takaoka K, Ono K (1992) The fate of nontraumatic avascular necrosis of the femoral head: a radiologic classification to formulate progress. Clin Orthop 277:73–78
Wang CJ, Yang YJ, Huang CC (2010) The effects of shockwave on systemic concentrations of nitric oxide level, angiogenesis and osteogenesis factors in hip necrosis. doi:10.1007/s00296-010-1384-7
Hausdorf J, Lutz A, Mayer-Wagner S, Birkenmaier C, Jansson V, Maier M (2010) Shock wave therapy for femoral head necrosis—pressure measurements inside the femoral head. J Biomech. doi:10.1016/j.jbiomech.2010.04.009
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Vulpiani, M.C., Vetrano, M., Trischitta, D. et al. Extracorporeal shock wave therapy in early osteonecrosis of the femoral head: prospective clinical study with long-term follow-up. Arch Orthop Trauma Surg 132, 499–508 (2012). https://doi.org/10.1007/s00402-011-1444-9
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DOI: https://doi.org/10.1007/s00402-011-1444-9