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Neurocytoma/rhabdomyoma (myoneurocytoma) of the cerebellum

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Abstract

An unusual case of cerebellar neurocytoma with rhabdomyomatous differentiation in a 6-year-old boy is reported. Immunocytochemical and ultrastructural features of the tumour were studied. Abortive synapse formation, the presence of clear vesicles and synaptophysin immunoreactivity of the tumour cells indicated its intermediate neuronal differentiation, while the presence of myoblasts and myotubes and immunolabelling by desmin confirmed the rhabdomyomatous differentiation. In addition, the mesenchymal cells variably expressed neurofilament protein and glial fibrillary acidic protein, suggesting inductive interaction between the neuroectodermal and ectomesenchymal elements and persistence of the pleuripotential nature of the cells along the rhombic area of the brain stem.

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Authors and Affiliations

  1. Department of Neuropathology, NIMHANS, Bangalore 560 029, India Fax: 91-080-663 1830; e-mail: shankar@nimhans.ren.nic.in, , , , , , IN

    Lily Pal, Vani Santosh, N. Gayathri, Sarala Das & S. K. Shankar

  2. Department of Neurosurgery, National Institute of Mental Health and Neurosciences, Bangalore 560 029, India, , , , , , IN

    B.S. Das

  3. Department of Neuroradiology, National Institute of Mental Health and Neuroscience, Bangalore 560 029, India, , , , , , IN

    P. N. Jayakumar

Authors
  1. Lily Pal
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  2. Vani Santosh
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  3. N. Gayathri
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  4. Sarala Das
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  5. B.S. Das
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  6. P. N. Jayakumar
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  7. S. K. Shankar
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Additional information

Received: 3 June 1997 / Revised, accepted: 15 September 1997

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Pal, L., Santosh, V., Gayathri, N. et al. Neurocytoma/rhabdomyoma (myoneurocytoma) of the cerebellum. Acta Neuropathol 95, 318–323 (1998). https://doi.org/10.1007/s004010050805

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  • DOI: https://doi.org/10.1007/s004010050805

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