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Myelin splitting, Schwann cell injury and demyelination in feline diabetic neuropathy

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Abstract

Nerve biopsy samples from two cats with spontaneously occurring diabetes were examined. The predominant nerve fiber abnormalities observed were restricted to the myelin sheath and Schwann cell. Reactive, degenerative and proliferative Schwann cell changes were evident but the most striking abnormality encountered was splitting and ballooning of the myelin sheath. These observations highlight the significance of Schwann cell injury in the pathogenesis of diabetic neuropathy.

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Authors and Affiliations

  1. Department of Pathology 0612, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0612, USA Tel.: 1-619-534-5331; Fax: 1-619-534-1886; e-mail: amizisin@ucsd.edu, , , , , , US

    A. P. Mizisin, G. Diane Shelton & Henry C. Powell

  2. Department of Veterinary Clinical Sciences, Veterinary Teaching Hospital, Ohio State University, Columbus, Ohio, USA, , , , , , US

    Susan Wagner

  3. Department of Small Animal Medicine and Surgery, The Royal Veterinary College, University of London, North Mymms, UK, , , , , , GB

    Clare Rusbridge

Authors
  1. A. P. Mizisin
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  2. G. Diane Shelton
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  3. Susan Wagner
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  4. Clare Rusbridge
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  5. Henry C. Powell
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Additional information

Received: 1 July 1997 / Revised: 26 August 1997 / Accepted: 8 September 1997

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Mizisin, A., Shelton, G., Wagner, S. et al. Myelin splitting, Schwann cell injury and demyelination in feline diabetic neuropathy. Acta Neuropathol 95, 171–174 (1998). https://doi.org/10.1007/s004010050783

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  • DOI: https://doi.org/10.1007/s004010050783

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