Availability of data
Data used in this study are available through request via the RADC research resource sharing hub (https://www.radc.rush.edu/).
References
Bennett DA, Buchman AS, Boyle PA, Barnes LL, Wilson RS, Schneider JA (2018) Religious orders study and rush memory and aging project. J Alzheimers Dis 64:S161–S189. https://doi.org/10.3233/jad-179939
Buchman AS, Yu L, Oveisgharan S, Farfel JM, Schneider JA, DaA B (2020) Person-specific contributions of brain pathologies to progressive parkinsonism in older adults. J Gerontol A Biol Sci Med Sci. https://doi.org/10.1093/gerona/glaa176;Inpress
Buchman AS, Yu L, Wilson RS, Leurgans SE, Nag S, Shulman JM et al (2019) Progressive parkinsonism in older adults is related to the burden of mixed brain pathologies. Neurology 92:e1821–e1830. https://doi.org/10.1212/wnl.0000000000007315
Schneider JA, Arvanitakis Z, Yu L, Boyle PA, Leurgans SE, Bennett DA (2012) Cognitive impairment, decline and fluctuations in older community-dwelling subjects with Lewy bodies. Brain 135:3005–3014. https://doi.org/10.1093/brain/aws234
Selen LP, Beek PJ, van Dieen JH (2005) Can co-activation reduce kinematic variability? A simulation study. Biol Cybern 93:373–381. https://doi.org/10.1007/s00422-005-0015-y
Funding
This study is funded by National Institute on Aging (Grant Nos. P30AG10161, R01AG15819, R01AG17917, R01AG47976, R01AG56352, R01AG59732), Illinois Department of Public Health and Robert C. Borwell Endowment Fund.
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Buchman, A.S., Wang, T., Yu, L. et al. Brain pathologies are associated with both the rate and variability of declining motor function in older adults. Acta Neuropathol 140, 587–589 (2020). https://doi.org/10.1007/s00401-020-02212-z
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DOI: https://doi.org/10.1007/s00401-020-02212-z