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Histone H3 wild-type DIPG/DMG overexpressing EZHIP extend the spectrum diffuse midline gliomas with PRC2 inhibition beyond H3-K27M mutation

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Data availability

The DNA methylation data analyzed in the current study have been deposited in the ArrayExpress database at EMBL-EBI under accession number E-MTAB-8888 [https://www.ebi.ac.uk/arrayexpress/].

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Acknowledgements

DC, DTWJ, JG and MAD acknowledge KickCancer-ITCC (Innovative Therapies for Children with Cancer), Etoile de Martin (annual grant support to DC and RARE program with the Fondation Carrefour “Les Boucles du Coeur”) and Imagine for Margo for the financial support of this project, Necker Imagine Tumor and DNA biobank (BB-033-00065) for tumor and blood samples and centers participating in the BIOMEDE International Study and national PIs (Karsten Nysom, Klas Blomgren, Darren Hargrave, Dannis Van Vuurden, Francisco Bautista-Sirvent, Geoffrey McCowage). CJ and AM acknowledge NHS funding to the NIHR Biomedical Research Centre at the Royal Marsden and the ICR, and support from Abbie’s Army and the CRIS Cancer Foundation. The INFORM personalised medicine study is supported by the Deutsche Krebshilfe, Deutsche Kinderkrebsstiftung, German Cancer Research Center (DKFZ), German Consortium for Translational Research (DKTK), the Shantella Stiftung, the “Ein Herz für Kinder” foundation and a donation from the Scheu family.

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Authors and Affiliations

  1. Molecular Predictors and New Targets in Oncology, INSERM, Gustave Roussy, Université Paris-Saclay, 114 rue Édouard Vaillant, Villejuif, 94800, France

    David Castel, Thomas Kergrohen, Samia Ghermaoui, Kévin Beccaria, Jacques Grill & Marie-Anne Debily

  2. Département de Cancérologie de l’Enfant et de l’Adolescent, Gustave Roussy, Université Paris-Saclay, Villejuif, France

    David Castel, Thomas Kergrohen & Jacques Grill

  3. Department of Neuropathology, GHU Paris Psychiatrie Neurosciences, Sainte-Anne Hospital, Paris, France

    Arnault Tauziède-Espariat, Emmanuèle Lechapt & Pascale Varlet

  4. Université de Paris, Paris, France

    Arnault Tauziède-Espariat, Emmanuèle Lechapt & Pascale Varlet

  5. Divisions of Molecular Pathology, The Institute of Cancer Research, London, UK

    Alan Mackay & Chris Jones

  6. Hopp Children’s Cancer Center Heidelberg (KiTZ), Heidelberg, Germany

    Stefan M. Pfister & David T. W. Jones

  7. Division of Pediatric Neurooncology (B062), German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany

    Stefan M. Pfister

  8. Department of Pediatric Hematology and Oncology, Heidelberg University Hospital, Heidelberg, Germany

    Stefan M. Pfister

  9. Division of Pediatric Hematology and Oncology, University Medical Center Goettingen, Goettingen, Germany

    Christof M. Kramm

  10. Department of Pediatric Radiology, IMAGINE Institute, INSERM UMR 1163, INSERM U1000, Hôpital Necker-Enfants Malades, Université de Paris, Paris, France

    Nathalie Boddaert

  11. Department of Pediatric Neurosurgery, Hôpital Necker-Enfants Malades, APHP, Université de Paris, Paris, France

    Thomas Blauwblomme, Stéphanie Puget & Kévin Beccaria

  12. Pediatric Glioma Research Group, German Cancer Research Center (DKFZ), Heidelberg, Germany

    David T. W. Jones

  13. Département de Biologie, Univ. Evry, Université Paris-Saclay, 23 boulevard de France, Evry, 91000, France

    Marie-Anne Debily

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  1. David Castel
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Correspondence to David Castel or Marie-Anne Debily.

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Castel, D., Kergrohen, T., Tauziède-Espariat, A. et al. Histone H3 wild-type DIPG/DMG overexpressing EZHIP extend the spectrum diffuse midline gliomas with PRC2 inhibition beyond H3-K27M mutation. Acta Neuropathol 139, 1109–1113 (2020). https://doi.org/10.1007/s00401-020-02142-w

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