Skip to main content
Log in

On the origin of tau seeding activity in Alzheimer’s disease

  • Correspondence
  • Published:
Acta Neuropathologica Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

References

  1. Andres-Benito P, Fernandez-Duenas V, Carmona M, Escobar LA, Torrejon-Escribano B, Aso E, Ciruela F, Ferrer I (2017) Locus coeruleus at asymptomatic early and middle Braak stages of neurofibrillary tangle pathology. Neuropathol Appl Neurobiol 43:373–392. https://doi.org/10.1111/nan.12386

    Article  CAS  PubMed  Google Scholar 

  2. Braak H, Alafuzoff I, Arzberger T, Kretzschmar H, Del Tredici K (2006) Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry. Acta Neuropathol 112:389–404

    Article  Google Scholar 

  3. Braak H, Del Tredici K (2011) The pathological process underlying Alzheimer’s disease in individuals under thirty. Acta Neuropathol 121:171–181

    Article  Google Scholar 

  4. Braak H, Thal DR, Ghebremedhin E, Del Tredici K (2011) Stages of the pathologic process in Alzheimer disease: age categories from 1 to 100 years. J Neuropathol Exp Neurol 70:960–969. https://doi.org/10.1097/NEN.0b013e318232a379

    Article  CAS  PubMed  Google Scholar 

  5. Ehrenberg AJ, Nguy AK, Theofilas P, Dunlop S, Suemoto CK, Alho ATD, Leite RP, Rodriguez RD, Mejia MB, Rub U et al (2017) Quantifying the accretion of hyperphosphorylated tau in the locus coeruleus and dorsal raphe nucleus: the pathological building blocks of early Alzheimer’s disease. Neuropathol Appl Neurobiol 43:393–408

    Article  CAS  Google Scholar 

  6. German DC, Walker BS, Manaye K, Smith WK, Woodward DJ, North AJ (1988) The human locus coeruleus: computer reconstruction of cellular distribution. J Neurosci 8:1776–1788

    Article  CAS  Google Scholar 

  7. Grinberg LT, Heinsen H (2017) Light at the beginning of the tunnel? Investigating early mechanistic changes in Alzheimer’s disease. Brain 140:2770–2773. https://doi.org/10.1093/brain/awx261

    Article  PubMed  Google Scholar 

  8. Grinberg LT, Rub U, Ferretti RE, Nitrini R, Farfel JM, Polichiso L, Gierga K, Jacob-Filho W, Heinsen H, Brazilian Brain Bank Study G (2009) The dorsal raphe nucleus shows phospho-tau neurofibrillary changes before the transentorhinal region in Alzheimer’s disease. A precocious onset? Neuropathol Appl Neurobiol 35:406–416. https://doi.org/10.1111/j.1365-2990.2009.00997.x

    Article  Google Scholar 

  9. Heinsen H, Henn R, Eisenmenger W, Götz M, Bohl J, Bethke B, Lockemann U, Püschel K (1994) Quantitative investigations on the human entorhinal area: left–right asymmetry and age-related changes. Anat Embryol (Berl) 190:181–194

    Article  CAS  Google Scholar 

  10. Kaufman SK, Del Tredici K, Thomas TL, Braak H, Diamond MI (2018) Tau seeding activity begins in the transentorhinal/entorhinal regions and anticipates phospho-tau pathology in Alzheimer’s disease and PART. Acta Neuropathol. https://doi.org/10.1007/s00401-018-1855-6

    Article  PubMed  PubMed Central  Google Scholar 

  11. Keren NI, Lozar CT, Harris KC, Morgan PS, Eckert MA (2009) In vivo mapping of the human locus coeruleus. Neuroimage 47:1261–1267. https://doi.org/10.1016/j.neuroimage.2009.06.012

    Article  PubMed  PubMed Central  Google Scholar 

  12. Montine TJ, Phelps CH, Beach TG, Bigio EH, Cairns NJ, Dickson DW, Duyckaerts C, Frosch MP, Masliah E, Mirra SS et al (2012) National Institute on Aging-Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’s disease: a practical approach. Acta Neuropathol 123:1–11

    Article  CAS  Google Scholar 

  13. Rorabaugh JM, Chalermpalanupap T, Botz-Zapp CA, Fu VM, Lembeck NA, Cohen RM, Weinshenker D (2017) Chemogenetic locus coeruleus activation restores reversal learning in a rat model of Alzheimer’s disease. Brain 140:3023–3038. https://doi.org/10.1093/brain/awx232

    Article  Google Scholar 

  14. Stratmann K, Heinsen H, Korf HW, Del Turco D, Ghebremedhin E, Seidel K, Bouzrou M, Grinberg LT, Bohl J, Wharton SB et al (2016) Precortical phase of Alzheimer’s disease (AD)-related tau cytoskeletal pathology. Brain Pathol 26:371–386. https://doi.org/10.1111/bpa.12289

    Article  CAS  PubMed  Google Scholar 

  15. Theofilas P, Ehrenberg AJ, Dunlop S, Di Lorenzo Alho AT, Nguy A, Leite RE, Rodriguez RD, Mejia MB, Suemoto CK, Ferretti-Rebustini RE et al (2017) Locus coeruleus volume and cell population changes during Alzheimer’s disease progression: a stereological study in human postmortem brains with potential implication for early-stage biomarker discovery. Alzheimers Dement 13:236–246. https://doi.org/10.1016/j.jalz.2016.06.2362

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Lea T. Grinberg.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Heinsen, H., Grinberg, L.T. On the origin of tau seeding activity in Alzheimer’s disease. Acta Neuropathol 136, 815–817 (2018). https://doi.org/10.1007/s00401-018-1890-3

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00401-018-1890-3

Navigation