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Deep sequencing of WNT-activated medulloblastomas reveals secondary SHH pathway activation

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Acknowledgements

J.B.I. is supported by the Arthur Purdy Stout Stipend Award. B.C.B. is supported by an NCI Outstanding Investigator Award (R35 CA220481). D.A.S. is supported by NIH Director’s Early Independence Award (DP5 OD021403).

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Author notes

  1. J. Bryan Iorgulescu

    Present address: Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA

Authors and Affiliations

  1. Department of Pathology, University of California, San Francisco, 513 Parnassus Ave, Health Sciences West 451, San Francisco, CA, 94143, USA

    J. Bryan Iorgulescu, Jessica Van Ziffle, Meredith Stevers, James P. Grenert, Boris C. Bastian, Tarik Tihan, Andrew W. Bollen, Arie Perry & David A. Solomon

  2. Clinical Cancer Genomics Laboratory, University of California, San Francisco, CA, USA

    Jessica Van Ziffle, James P. Grenert, Boris C. Bastian & David A. Solomon

  3. Hopp Children′s Cancer Center, NCT Heidelberg (KiTZ), Heidelberg, Germany

    Lukas Chavez, Marcel Kool & Stefan Pfister

  4. Department of Neuropathology, Heidelberg University Hospital, Heidelberg, Germany

    Damian Stichel & Andrey Korshunov

  5. Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), Heidelberg, Germany

    Damian Stichel & Andrey Korshunov

  6. Division of Pediatric Neuro-oncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany

    Lukas Chavez, Damian Stichel, Marcel Kool, Stefan Pfister & Andrey Korshunov

  7. Division of Applied Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany

    Ivo Buchhalter

  8. Department for Bioinformatics and Functional Genomics, Institute for Pharmacy and Molecular Biotechnology (IPMB), Heidelberg University, Heidelberg, Germany

    Ivo Buchhalter

  9. Division of Pediatric Hematology/Oncology, Valley Children’s Hospital, Madera, CA, USA

    David Samuel

  10. Division of Pediatric Hematology/Oncology, Department of Pediatrics, University of California, San Francisco, CA, USA

    Theodore Nicolaides, Anuradha Banerjee & Sabine Mueller

  11. Department of Neurological Surgery, University of California, San Francisco, CA, USA

    Theodore Nicolaides, Anuradha Banerjee, Sabine Mueller, Nalin Gupta & Arie Perry

  12. Department of Neurology, University of California, San Francisco, CA, USA

    Sabine Mueller

  13. Department of Developmental Neurobiology, St Jude Children’s Research Hospital, Memphis, TN, USA

    Paul A. Northcott

  14. Department of Pediatric Hematology and Oncology, Heidelberg University Hospital, Heidelberg, Germany

    Stefan Pfister

Authors
  1. J. Bryan Iorgulescu
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  2. Jessica Van Ziffle
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  13. Nalin Gupta
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  14. Tarik Tihan
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  15. Andrew W. Bollen
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  16. Paul A. Northcott
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  17. Marcel Kool
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  18. Stefan Pfister
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  19. Andrey Korshunov
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  20. Arie Perry
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  21. David A. Solomon
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Corresponding author

Correspondence to David A. Solomon.

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The authors declare that they have no competing interests related to this report.

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Iorgulescu, J.B., Van Ziffle, J., Stevers, M. et al. Deep sequencing of WNT-activated medulloblastomas reveals secondary SHH pathway activation. Acta Neuropathol 135, 635–638 (2018). https://doi.org/10.1007/s00401-018-1819-x

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  • DOI: https://doi.org/10.1007/s00401-018-1819-x

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