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DNA-methylation profiling discloses significant advantages over NanoString method for molecular classification of medulloblastoma

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References

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Authors and Affiliations

  1. Clinical Cooperation Unit Neuropathology (G380), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany

    Andrey Korshunov & Andreas von Deimling

  2. Department of Neuropathology, Heidelberg University Hospital, Im Neuenheimer Feld 224, 69120, Heidelberg, Germany

    Andrey Korshunov & Andreas von Deimling

  3. German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany

    Andrey Korshunov, David T. W. Jones, Andreas von Deimling, Stefan M. Pfister & Marcel Kool

  4. Division of Pediatric Neurooncology (B062), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany

    Lukas Chavez, Tanvi Sharma, David T. W. Jones, Stefan M. Pfister & Marcel Kool

  5. Department of Developmental Neurobiology, St. Jude Children’s Research Hospital, Memphis, TN, USA

    Paul A. Northcott

  6. Department of Neuropathology, NN Burdenko Neurosurgical Institute, 5-th Tverskaya-Yamskaya Str. 16, Moscow, Russia

    Marina Ryzhova

  7. Department of Pediatric Hematology and Oncology, Heidelberg University Hospital, Im Neuenheimer Feld 430, 69120, Heidelberg, Germany

    Stefan M. Pfister

Authors
  1. Andrey Korshunov
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  2. Lukas Chavez
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  3. Paul A. Northcott
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  4. Tanvi Sharma
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  5. Marina Ryzhova
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  6. David T. W. Jones
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  7. Andreas von Deimling
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  8. Stefan M. Pfister
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  9. Marcel Kool
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Corresponding author

Correspondence to Andrey Korshunov.

Electronic supplementary material

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401_2017_1776_MOESM1_ESM.pdf

Supplementary Figure 1. Example of tumor which was classified with CodeSet as Group 3 MB but re-classified as Ewing sarcoma. a. H&E—small round cell cerebellar tumor diagnosed as MB. b. Strong synaptophysin expression. c. Cytogenetic profile revealed rearrangements on chromosome 22q. d. FISH analysis with ESWR1 break-apart probe. The cell nuclei show the one fusion, one orange, and one green signal pattern indicative of a rearrangement of one copy of the EWSR1 region. (PDF 251 kb)

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Korshunov, A., Chavez, L., Northcott, P.A. et al. DNA-methylation profiling discloses significant advantages over NanoString method for molecular classification of medulloblastoma. Acta Neuropathol 134, 965–967 (2017). https://doi.org/10.1007/s00401-017-1776-9

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  • DOI: https://doi.org/10.1007/s00401-017-1776-9

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