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Optineurin is co-localized with FUS in basophilic inclusions of ALS with FUS mutation and in basophilic inclusion body disease

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Acknowledgments

This work was supported in part by grants-in-aid for scientific research from the Japan Society for the Promotion of Science (No. 21500336) and from the Japan Science and Technology Agency (AS2211173G). We thank Dr. Toshio Oyama (Yamanashi Prefectural Central Hospital) for providing materials from ‘FALS with FUS mutation’ patient No. 1, and Drs. Makoto Arai and Haruhiko Akiyama (Tokyo Institute of Psychiatry) for genetic analysis of ‘FALS with FUS mutation’ patient No. 3.

Conflict of interest

The authors report no conflicts of interest.

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Authors and Affiliations

  1. Department of Neurology, Kansai Medical University, Osaka, Japan

    Hidefumi Ito, Kengo Fujita, Masataka Nakamura, Reika Wate, Satoshi Kaneko & Hirofumi Kusaka

  2. Department of Neurology, Kyoto University Graduate School of Medicine, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan

    Hidefumi Ito & Ryosuke Takahashi

  3. Department of Neurology, Tokyo Women’s Medical University, Tokyo, Japan

    Shoichi Sasaki

  4. Department of Neurology, Ohta-Atami Hospital, Koriyama, Japan

    Kiyomi Yamane

  5. Department of Neurology, Tohoku University School of Medicine, Sendai, Japan

    Naoki Suzuki & Masashi Aoki

  6. Department of Pathology, Tokyo Women’s Medical University, Tokyo, Japan

    Noriyuki Shibata

  7. Department of Neurology, Kofu City Hospital, Kofu, Japan

    Shinji Togashi

  8. Department of Neurology and Pathology, Tokyo Metropolitan Neurological Hospital, Tokyo, Japan

    Akihiro Kawata, Yoko Mochizuki & Toshio Mizutani

  9. Department of Epidemiology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan

    Hirofumi Maruyama & Hideshi Kawakami

  10. Division of Neuropathology, Montefiore Medical Center, New York, NY, USA

    Asao Hirano

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  1. Hidefumi Ito
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  2. Kengo Fujita
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  15. Hirofumi Maruyama
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  16. Asao Hirano
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  17. Ryosuke Takahashi
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  19. Hirofumi Kusaka
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Corresponding author

Correspondence to Hidefumi Ito.

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Ito, H., Fujita, K., Nakamura, M. et al. Optineurin is co-localized with FUS in basophilic inclusions of ALS with FUS mutation and in basophilic inclusion body disease. Acta Neuropathol 121, 555–557 (2011). https://doi.org/10.1007/s00401-011-0809-z

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  • DOI: https://doi.org/10.1007/s00401-011-0809-z

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