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Neurofibrillary tangle-predominant dementia: comparison with classical Alzheimer disease

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Abstract

Neurofibrillary tangle predominant dementia (NFTPD) is a subset of late onset dementia, clinically different from traditional “plaque and tangle” Alzheimer disease (AD): later onset, shorter duration, less severe cognitive impairment, and almost absence of ApoE ε4. Neuropathology reveals abundant allocortical neurofibrillary pathology with no or few isocortical tau lesions, absence of neuritic plaques, absence or scarcity of amyloid deposits, but neurofibrillary changes comprising both 3 and 4 repeat (3R and 4R) tau immunohistochemistry are not significantly different from those in classical AD. Comparing 51 autopsy cases of NFTPD with 244 classical AD subjects, the nosology of NFTPD and its differences from AD are discussed.

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References

  1. Amano N, Mizutani T, Otani T, Kase A, Saitoh A, Matsushita M, Yagishita S (1994) Clinicopathological investigations of atypical senile dementia of Alzheimer type. Neuropathology 14:127–136

    Google Scholar 

  2. Arai T, Ikeda K, Akiyama H, Tsuchiya K, Iritani S, Ishiguro K, Yagishita S, Oda T, Odawara T, Iseki E (2003) Different immunoreactivities of the microtubule-binding region of tau and its molecular basis in brains from patients with Alzheimer’s disease, Pick’s disease, progressive supranuclear palsy and corticobasal degeneration. Acta Neuropathol (Berl) 105:489–498

    CAS  Google Scholar 

  3. Attems A, Quass M, Jellinger KA (2006) Tau and alpha-synuclein brainstem pathology in Alzheimer disease. Relations with extrapyramidal signs. Acta Neuropathol DOI 10.1007/s00401-006-0146-9

  4. Attems J, Jellinger KA (2006) Tau and alpha-synuclein brainstem pathology in Alzheimer disease (abstract). Neuropathol Appl Neurobiol 33:2–3

    Google Scholar 

  5. Attems J, Jellinger KA (2006) Hippocampal sclerosis in Alzheimer disease and other dementias. Neurology 66:775

    Article  PubMed  Google Scholar 

  6. Bales KR, Verina T, Dodel RC, Du Y, Altstiel L, Bender M, Hyslop P, Johnstone EM, Little SP, Cummins DJ, Piccardo P, Ghetti B, Paul SM (1997) Lack of apolipoprotein E dramatically reduces amyloid beta-peptide deposition. Nat Genet 17:263–264

    Article  CAS  PubMed  Google Scholar 

  7. Bancher C, Brunner C, Lassmann H, Budka H, Jellinger K, Wiche G, Seitelberger F, Grundke-Iqbal I, Iqbal K, Wisniewski HM (1989) Accumulation of abnormally phosphorylated tau precedes the formation of neurofibrillary tangles in Alzheimer’s disease. Brain Res 477:90–99

    Article  CAS  PubMed  Google Scholar 

  8. Bancher C, Jellinger KA (1994) Neurofibrillary tangle predominant form of senile dementia of Alzheimer type: a rare subtype in very old subjects. Acta Neuropathol (Berl) 88:565–570

    CAS  Google Scholar 

  9. Bancher C, Egensperger R, Kosel S, Jellinger K, Graeber MB (1997) Low prevalence of apolipoprotein E epsilon 4 allele in the neurofibrillary tangle predominant form of senile dementia. Acta Neuropathol (Berl) 94:403–409

    Article  CAS  Google Scholar 

  10. Beach TG, Sue L, Scott S, Layne K, Newell A, Walker D, Baker M, Sahara N, Yen SH, Hutton M, Caselli R, Adler C, Connor D, Sabbagh M (2003) Hippocampal sclerosis dementia with tauopathy. Brain Pathol 13:263–278

    Article  PubMed  Google Scholar 

  11. Berg L, McKeel DW Jr, Miller JP, Baty J, Morris JC (1993) Neuropathological indexes of Alzheimer’s disease in demented and nondemented persons aged 80 years and older. Arch Neurol 50:349–358

    CAS  PubMed  Google Scholar 

  12. Braak H, Braak E (1991) Neuropathological staging of Alzheimer-related changes. Acta Neuropathol (Berl) 82:239–259

    Article  CAS  Google Scholar 

  13. Braak H, Alafuzoff I, Arzberger T, Kretzschmar H, Del Tredici K (2006) Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry. Acta Neuropathol (Berl) 112:389–404

    Article  Google Scholar 

  14. Buee L, Delacourte A (1999) Comparative biochemistry of tau in progressive supranuclear palsy, corticobasal degeneration, FTDP-17 and Pick’s disease. Brain Pathol 9:681–693

    Article  CAS  PubMed  Google Scholar 

  15. Cairns NJ, Grinber LT, Liscic RM, Tu P, Morris JC (2006) Expanding the neuropathological spectrum of frontotemporal lobar degenerations: review of 833 prospectively assessed dementia cases (abstract). J Neural Transm 113:VII

    Google Scholar 

  16. Corder EH, Saunders AM, Strittmatter WJ, Schmechel DE, Gaskell PC, Small GW, Roses AD, Haines JL, Pericak-Vance MA (1993) Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer’s disease in late onset families. Science 261:921–923

    Article  CAS  PubMed  Google Scholar 

  17. Corder EH, Saunders AM, Risch NJ, Strittmatter WJ, Schmechel DE, Gaskell PC Jr, Rimmler JB, Locke PA, Conneally PM, Schmader KE et al (1994) Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease. Nat Genet 7:180–184

    Article  CAS  PubMed  Google Scholar 

  18. Corder EH, Lannfelt L, Viitanen M, Corder LS, Manton KG, Winblad B, Basun H (1996) Apolipoprotein E genotype determines survival in the oldest old (85 years or older) who have good cognition. Arch Neurol 53:418–422

    CAS  PubMed  Google Scholar 

  19. de Silva R, Lashley T, Gibb G, Hanger D, Hope A, Reid A, Bandopadhyay R, Utton M, Strand C, Jowett T, Khan N, Anderton B, Wood N, Holton J, Revesz T, Lees A (2003) Pathological inclusion bodies in tauopathies contain distinct complements of tau with three or four microtubule-binding repeat domains as demonstrated by new specific monoclonal antibodies. Neuropathol Appl Neurobiol 29:288–302

    Article  PubMed  Google Scholar 

  20. de Silva R, Lashley T, Strand C, Shiarli AM, Shi J, Tian J, Bailey KL, Davies P, Bigio EH, Arima K, Iseki E, Murayama S, Kretzschmar H, Neumann M, Lippa C, Halliday G, Mackenzie J, Ravid R, Dickson D, Wszolek Z, Iwatsubo T, Pickering-Brown SM, Holton J, Lees A, Revesz T, Mann DM (2006) An immunohistochemical study of cases of sporadic and inherited frontotemporal lobar degeneration using 3R- and 4R-specific tau monoclonal antibodies. Acta Neuropathol (Berl) 111:329–340

    Article  Google Scholar 

  21. Delacourte A, Buee L (2000) Tau pathology: a marker of neurodegenerative disorders. Curr Opin Neurol 13:371–376

    Article  CAS  PubMed  Google Scholar 

  22. Delacourte A (2005) Alzheimer’s disease: a true tauopathy fueled by amyloid precursor protein dysfunction. In: Hanin I, Cacabelos R, Fisher A (eds) Progress in Alzheimer’s and Parkinson’s. Taylor & Francis, London, pp 301–307

    Google Scholar 

  23. Delaere P, Duyckaerts C, He Y, Piette F, Hauw JJ (1991) Subtypes and differential laminar distributions of beta A4 deposits in Alzheimer’s disease: relationship with the intellectual status of 26 cases. Acta Neuropathol (Berl) 81:328–335

    Article  CAS  Google Scholar 

  24. Delaere P, He Y, Fayet G, Duyckaerts C, Hauw JJ (1993) Beta A4 deposits are constant in the brain of the oldest old: an immunocytochemical study of 20 French centenarians. Neurobiol Aging 14:191–194

    Article  CAS  PubMed  Google Scholar 

  25. Dickson DE (2001) Progressive supranuclear palsy and corticobasal degeneration. In: Hof RR, Mobbs LCK (eds) Functional neurobiology of aging. Academic Press, San Diego, pp 155–171

    Google Scholar 

  26. Dickson DW, Davies P, Bevona C, Van Hoeven KH, Factor SM, Grober E, Aronson MK, Crystal HA (1994) Hippocampal sclerosis: a common pathological feature of dementia in very old (> or =80 years of age) humans. Acta Neuropathol (Berl) 88:212–221

    CAS  Google Scholar 

  27. Dickson DW, Bergeron C, Chin SS, Duyckaerts C, Horoupian D, Ikeda K, Jellinger K, Lantos PL, Lippa CF, Mirra SS, Tabaton M, Vonsattel JP, Wakabayashi K, Litvan I (2002) Office of rare diseases neuropathologic criteria for corticobasal degeneration. J Neuropathol Exp Neurol 61:935–946

    CAS  PubMed  Google Scholar 

  28. Dickson DW (2004) Sporadic tauopathies: Pick’s disease, corticobasal degeneration, progressive supranuclear palsy and argyrophilic grain disease. In: Esiri MM, Lee VM-Y, Trojanowski JQ (eds) The neuropathology of dementia, 2nd edn. Cambridge University Press, London, pp 227–256

    Google Scholar 

  29. Dickson DW (2005) Required techniques and useful molecular markers in the neuropathologic diagnosis of neurodegenerative diseases. Acta Neuropathol (Berl) 109:14–24

    Article  Google Scholar 

  30. Dickson DW (2006) Differential diagnosis of the sporadic tauopathies (abstract). Brain Pathol 16(suppl 1):S5

    Google Scholar 

  31. Ding ZT, Wang Y, Jiang YP, Yoshida M, Mimuro M, Inagaki T, Iwase T, Hashizume Y (2006) Argyrophilic grain disease: frequency and neuropathology in centenarians. Acta Neuropathol (Berl) 111:320–328

    Article  Google Scholar 

  32. Duyckaerts C (2005) Atypical parkinsonian disorders. In: Litvan I (eds) Current clinical neurology: atypical parkinsonian disorders. Humana Press. Totowa, pp 111–138

    Google Scholar 

  33. Enstice KM, Hladik CL, Stark JM, Bigio EH, White CL (2006) Preferential 3-repeat tau staining of extracellular neurofibrillary tangles in tangle predominant senile dementia (abstract). Brain Pathol 16(suppl 1):S49

    Google Scholar 

  34. Feany MB, Dickson DW (1995) Widespread cytoskeletal pathology characterizes corticobasal degeneration. Am J Pathol 146:1388–1396

    CAS  PubMed  Google Scholar 

  35. Feany MB, Dickson DW (1996) Neurodegenerative disorders with extensive tau pathology: a comparative study and review. Ann Neurol 40:139–148

    Article  CAS  PubMed  Google Scholar 

  36. Feany MB, Mattiace LA, Dickson DW (1996) Neuropathologic overlap of progressive supranuclear palsy, Pick’s disease and corticobasal degeneration. J Neuropathol Exp Neurol 55:53–67

    CAS  PubMed  Google Scholar 

  37. Fujino Y, Wang DS, Thomas N, Espinoza M, Davies P, Dickson DW (2005) Increased frequency of argyrophilic grain disease in Alzheimer disease with 4R tau-specific immunohistochemistry. J Neuropathol Exp Neurol 64:209–214

    CAS  PubMed  Google Scholar 

  38. Giannakopoulos P, Hof PR, Surini M, Michel JP, Bouras C (1993) Quantitative immunohistochemical analysis of the distribution of neurofibrillary tangles and senile plaques in the cerebral cortex of nonagenarians and centenarians. Acta Neuropathol (Berl) 85:602–610

    Article  CAS  Google Scholar 

  39. Greenberg SM, Vonsattel JP, Segal AZ, Chiu RI, Clatworthy AE, Liao A, Hyman BT, Rebeck GW (1998) Association of apolipoprotein E epsilon2 and vasculopathy in cerebral amyloid angiopathy. Neurology 50:961–965

    CAS  PubMed  Google Scholar 

  40. Hasegawa M, Smith MJ, Iijima M, Tabira T, Goedert M (1999) FTDP-17 mutations N279K and S305N in tau produce increased splicing of exon 10. FEBS Lett 443:93–96

    Article  CAS  PubMed  Google Scholar 

  41. Hong M, Zhukareva V, Vogelsberg-Ragaglia V, Wszolek Z, Reed L, Miller BI, Geschwind DH, Bird TD, McKeel D, Goate A, Morris JC, Wilhelmsen KC, Schellenberg GD, Trojanowski JQ, Lee VM (1998) Mutation-specific functional impairments in distinct tau isoforms of hereditary FTDP-17. Science 282:1914–1917

    Article  CAS  PubMed  Google Scholar 

  42. Hutton M, Lendon CL, Rizzu P, Baker M, Froelich S, Houlden H, Pickering-Brown S, Chakraverty S, Isaacs A, Grover A, Hackett J, Adamson J, Lincoln S, Dickson D, Davies P, Petersen RC, Stevens M, de Graaff E, Wauters E, van Baren J, Hillebrand M, Joosse M, Kwon JM, Nowotny P, Che LK, Norton J, Morris JC, Reed LA, Trojanowski J, Basun H, Lannfelt L, Neystat M, Fahn S, Dark F, Tannenberg T, Dodd PR, Hayward N, Kwok JB, Schofield PR, Andreadis A, Snowden J, Craufurd D, Neary D, Owen F, Oostra BA, Hardy J, Goate A, van Swieten J, Mann D, Lynch T, Heutink P (1998) Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17. Nature 393:702–705

    Article  CAS  PubMed  Google Scholar 

  43. Hyman BT, Augustinack JC, Ingelsson M (2005) Transcriptional and conformational changes of the tau molecule in Alzheimer’s disease. Biochim Biophys Acta 1739:150–157

    CAS  PubMed  Google Scholar 

  44. Ikeda K, Akiyama H, Kondo H, Haga C, Tanno E, Tokuda T, Ikeda S (1995) Thorn-shaped astrocytes: possibly secondarily induced tau-positive glial fibrillary tangles. Acta Neuropathol (Berl) 90:620–625

    CAS  Google Scholar 

  45. Ikeda K, Akiyama H, Arai T, Sahara N, Mori H, Usami M, Sakata M, Mizutani T, Wakabayashi K, Takahashi H (1997) A subset of senile dementia with high incidence of the apolipoprotein E epsilon2 allele. Ann Neurol 41:693–695

    Article  CAS  PubMed  Google Scholar 

  46. Ikeda K, Akiyama H, Sahara N, Mori H, Usami M, Sakata M, Mizutani T, Wakabayashi K, Takahasi H (1997) Senile dementia with abundant neurofibrillary tangles without accompanying senile plaques: a subset of senile dementia with high incidence of the ApoE epsilon2 allele. In: Iqbal K, Winblad B, Nishimura T, Takeda M, Wisniewski HM (eds) Alzheimer’s disease: biology, diagnosis and therapeutics. Wiley, New York, pp 257–265

    Google Scholar 

  47. Ikeda K, Akiyama H, Arai T, Oda T, Kato M, Iseki E, Kosaka K, Wakabayashi K, Takahashi H (1999) Clinical aspects of ‘senile dementia of the tangle type’: a subset of dementia in the senium separable from late-onset Alzheimer’s disease. Dement Geriatr Cogn Disord 10:6–11

    Article  CAS  PubMed  Google Scholar 

  48. Ingelsson M, Ramasamy K, Cantuti-Castelvetri I, Skoglund L, Matsui T, Orne J, Kowa H, Raju S, Vanderburg CR, Augustinack JC, de Silva R, Lees AJ, Lannfelt L, Growdon JH, Frosch MP, Standaert DG, Irizarry MC, Hyman BT (2006) No alteration in tau exon 10 alternative splicing in tangle-bearing neurons of the Alzheimer’s disease brain. Acta Neuropathol (Berl) 112:439–449

    Article  CAS  Google Scholar 

  49. Iseki E, Togo T, Suzuki K, Katsuse O, Marui W, de Silva R, Lees A, Yamamoto T, Kosaka K (2003) Dementia with Lewy bodies from the perspective of tauopathy. Acta Neuropathol (Berl) 105:265–270

    CAS  Google Scholar 

  50. Iseki E, Yamamoto R, Minegishi M, Togo T, Katsuse O, Kosaka K, Akiyama H, Tsuchiya K, de Silva R, Andrew L, Arai H (2006) Immunohistochemical investigation of neurofibrillary tangles and their tau informs in brains of limbic neurofibrillary tangle formation. Neurosci Lett 405:29–33

    Article  CAS  PubMed  Google Scholar 

  51. Ishizawa T, Ko LW, Cookson N, Davias P, Espinoza M, Dickson DW (2002) Selective neurofibrillary degeneration of the hippocampal CA2 sector is associated with four-repeat tauopathies. J Neuropathol Exp Neurol 61:1040–1047

    CAS  PubMed  Google Scholar 

  52. Itoh Y, Yamada M, Suematsu N, Matsushita M, Otomo E (1998) An immunohistochemical study of centenarian brains: a comparison. J Neurol Sci 157:73–81

    Article  CAS  PubMed  Google Scholar 

  53. Jellinger KA, Bancher C (1998) Senile dementia with tangles (tangle predominant form of senile dementia). Brain Pathol 8:367–376

    Article  CAS  PubMed  Google Scholar 

  54. Jellinger KA (2003) Plaque-predominant and tangle-predominant variants of Alzheimer’s disease. In: Dickson DW (ed) Neurodegeneration: the molecular pathology of dementia and movement disorders. ISN Neuropath Press, Basel, pp 66–68

    Google Scholar 

  55. Jellinger KA, Attems J (2003) Incidence of cerebrovascular lesions in Alzheimer disease: a postmortem study. Acta Neuropathol 105:14–17

    PubMed  Google Scholar 

  56. Jellinger KA (2005) Neuropathology and tau. In: Hanin I, Cacabelos R, Fisher A (eds) Recent progress in Alzheimer’s and Parkinson’s disease. Taylor & Francis, New York, pp 317–327

    Google Scholar 

  57. Jellinger KA, Attems J (2005) Alzheimer pathology in the olfactory bulb. Neuropathol Appl Neurobiol 31:203

    Article  CAS  PubMed  Google Scholar 

  58. Jellinger KA (2006) A view on early diagnosis of dementias from neuropathology. In: Herholz K, Morris C, Perani D (eds) Early diagnosis of dementias. Taylor & Francis, New York, pp 311–428

    Google Scholar 

  59. Kitamura T, Sugimori K, Sudou S, Shimazaki M, Uotani C, Kobayashi K, Koshino Y (2006) Relationship between microtubule-binding repeats and morphology of neurofibrillary tangle in Alzheimer’s disease (abstract). Neuropathology 26:A8

    Article  Google Scholar 

  60. Knopman DS (2003) Alzheimer type dementia. In: Dickson erani D (eds) Dickson DW (ed) Neurodegeneration: the molecular pathology of dementia and movement disorders. ISN Neuropath Press, Basel, pp 24–39

    Google Scholar 

  61. Komori T, Arai N, Oda M, Nakayama H, Mori H, Yagishita S, Takahashi T, Amano N, Murayama S, Murakami S, Shibata N, Kobayashi M, Sasaki S, Iwata M (1998) Astrocytic plaques and tufts of abnormal fibers do not coexist in corticobasal degeneration and progressive supranuclear palsy. Acta Neuropathol (Berl) 96:401–408

    Article  CAS  Google Scholar 

  62. Kosaka K, Iseki E, Odawara T, Hino H, Kanai A, Kato M (1997) Limbic neurofibrillary tangle dementia (LNTD) (abstract). Brain Pathol 7:1114

    Google Scholar 

  63. LaDu MJ, Lukens JR, Reardon CA, Getz GS (1997) Association of human, rat, and rabbit apolipoprotein E with beta-amyloid. J Neurosci Res 49:9–18

    Article  CAS  PubMed  Google Scholar 

  64. Lee VM, Kenyon TK, Trojanowski JQ (2005) Transgenic animal models of tauopathies. Biochim Biophys Acta 1739:251–259

    CAS  PubMed  Google Scholar 

  65. Ma J, Yee A, Brewer HB Jr, Das S, Potter H (1994) Amyloid-associated proteins alpha 1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer beta-protein into filaments. Nature 372:92–94

    Article  CAS  PubMed  Google Scholar 

  66. Matsumoto S, Udaka F, Kameyama M, Kusaka H, Ito H, Imai T (1996) Subcortical neurofibrillary tangles, neuropil threads, and argentophilic glial inclusions in corticobasal degeneration. Clin Neuropathol 15:209–214

    CAS  PubMed  Google Scholar 

  67. Mirra SS, Gearing M, McKeel DW Jr, Crain BJ, Hughes JP, van Belle G, Heyman A (1994) Interlaboratory comparison of neuropathology assessments in Alzheimer’s disease: a study of the consortium to establish a registry for Alzheimer’s disease (CERAD). J Neuropathol Exp Neurol 53:303–315

    CAS  PubMed  Google Scholar 

  68. Mirra SS, Hyman BT (2002) Aging and dementia. In: Graham DI, Lantos PL (eds) Greenfield’s Neuropathology, 7th edn. E. Arnold, London, pp 195–271

    Google Scholar 

  69. Mizutani T, Shimada H (1992) Neuropathological background of twenty-seven centenarian brains. J Neurol Sci 108:168–177

    Article  CAS  PubMed  Google Scholar 

  70. Nicoll JA, Burnett C, Love S, Graham DI, Dewar D, Ironside JW, Stewart J, Vinters HV (1997) High frequency of apolipoprotein E epsilon 2 allele in hemorrhage due to cerebral amyloid angiopathy. Ann Neurol 41:716–721

    Article  CAS  PubMed  Google Scholar 

  71. Nishimura M, Tomimoto H, Suenaga T, Namba Y, Ikeda K, Akiguchi I, Kimura J (1995) Immunocytochemical characterization of glial fibrillary tangles in Alzheimer’s disease brain. Am J Pathol 146:1052–1058

    CAS  PubMed  Google Scholar 

  72. Noda K, Sasaki K, Fujimi K, Wakisaki Y, Tanizaki Y, Wakugawa Y, Iida M, Iwaki T (2006) Neuropathological study on senile dementia of the neurofibrillary tangle type (tangle-only dementia) in general population: the Hisayama study (abstract). Neuropathology 26:A9

    Article  Google Scholar 

  73. Rebeck GW, Reiter JS, Strickland DK, Hyman BT (1993) Apolipoprotein E in sporadic Alzheimer’s disease: allelic variation and receptor interactions. Neuron 11:575–580

    Article  CAS  PubMed  Google Scholar 

  74. Reed LA, Grabowski TJ, Schmidt ML, Morris JC, Goate A, Solodkin A, Van Hoesen GW, Schelper RL, Talbot CJ, Wragg MA, Trojanowski JQ (1997) Autosomal dominant dementia with widespread neurofibrillary tangles. Ann Neurol 42:564–572

    Article  CAS  PubMed  Google Scholar 

  75. Sergeant N, David JP, Goedert M, Jakes R, Vermersch P, Buee L, Lefranc D, Wattez A, Delacourte A (1997) Two-dimensional characterization of paired helical filament-tau from Alzheimer’s disease: demonstration of an additional 74-kDa component and age-related biochemical modifications. J Neurochem 69:834–844

    Article  CAS  PubMed  Google Scholar 

  76. Spires TL, Orne JD, SantaCruz K, Pitstick R, Carlson GA, Ashe KH, Hyman BT (2006) Region-specific dissociation of neuronal loss and neurofibrillary pathology in a mouse model of tauopathy. Am J Pathol 168:1598–1607

    CAS  PubMed  Google Scholar 

  77. Takahashi T, Amano N, Hanihara T, Nagatomo H, Yagishita S, Itoh Y, Yamaoka K, Toda H, Tanabe T (1996) Corticobasal degeneration: widespread argentophilic threads and glia in addition to neurofibrillary tangles: similarities of cytoskeletal abnormalities in corticobasal degeneration and progressive supranuclear palsy. J Neurol Sci 138:66–77

    Article  CAS  PubMed  Google Scholar 

  78. Thal DR, Braak H (2005) Post-mortem diagnosis of Alzheimer’s disease. Pathologe 26:201–213

    Article  CAS  PubMed  Google Scholar 

  79. Tiraboschi P, Yaari R, Hansen LA, Ho G, Thal LJ, Salmon D, Corey-Bloom J (2006) Neurofibrillary tangle-predominant dementia (abstract). Neurology 66(suppl 2):A379

    Google Scholar 

  80. Togo T, Sahara N, Yen SH, Cookson N, Ishizawa T, Hutton M, de Silva R, Lees A, Dickson DW (2002) Argyrophilic grain disease is a sporadic 4-repeat tauopathy. J Neuropathol Exp Neurol 61:547–556

    CAS  PubMed  Google Scholar 

  81. Togo T, Akiyama H, Iseki E, Uchikado H, Kondo H, Ikeda K, Tsuchiya K, de Silva R, Lees A, Kosaka K (2004) Immunohistochemical study of tau accumulation in early stages of Alzheimer-type neurofibrillary lesions. Acta Neuropathol (Berl) 107:504–508

    Article  CAS  Google Scholar 

  82. Tolnay M, Spillantini MG, Goedert M, Ulrich J, Langui D, Probst A (1997) Argyrophilic grain disease: widespread hyperphosphorylation of tau protein in limbic neurons. Acta Neuropathol (Berl) 93:477–484

    Article  CAS  Google Scholar 

  83. Tolnay M, Sergeant N, Ghestem A, Chalbot S, De Vos RA, Jansen Steur EN, Probst A, Delacourte A (2002) Argyrophilic grain disease and Alzheimer’s disease are distinguished by their different distribution of tau protein isoforms. Acta Neuropathol (Berl) 104:425–434

    CAS  Google Scholar 

  84. Tolnay M, Villoz N, Probst A, Miserez AR (2003) Apolipoprotein E genotype in senile dementia with tangles differs from Alzheimer’s disease. Neuropathol Appl Neurobiol 29:80–84

    Article  CAS  PubMed  Google Scholar 

  85. Tolnay M, Clavaguera F (2004) Argyrophilic grain disease: a late-onset dementia with distinctive features among tauopathies. Neuropathology 24:269–283

    Article  PubMed  Google Scholar 

  86. Tsuboi Y, Josephs KA, Cookson N, Dickson DW (2003) ApoE E4 is a determinant for Alzheimer type pathology in progressive supranuclear palsy. Neurology 60:240–245

    CAS  PubMed  Google Scholar 

  87. Ulrich J, Spillantini MG, Goedert M, Dukas L, Staehelin HB (1992) Abundant neurofibrillary tangles without senile plaques in a subset of patients with senile dementia. Neurodegeneration 1:257–284

    Google Scholar 

  88. Yamada M, Itoh Y, Otomo E, Suematsu N, Matsushita M (1996) Dementia of the Alzheimer type and related dementias in the aged: DAT subgroups and senile dementia of the neurofibrillary tangle type. Neuropathology 16:89–98

    Google Scholar 

  89. Yamada M, Itoh Y, Sodeyama N, Suematsu N, Otomo E, Matsushita M, Mizusawa H (2001) Senile dementia of the neurofibrillary tangle type: a comparison with Alzheimer’s disease. Dement Geriatr Cogn Disord 12:117–126

    Article  CAS  PubMed  Google Scholar 

  90. Yamada M (2002) Risk factors for cerebral amyloid angiopathy in the elderly. Ann N Y Acad Sci 977:37–44

    Article  PubMed  Google Scholar 

  91. Yamada M (2003) Senile dementia of the neurofibrillary tangle type (tangle-only dementia): neuropathological criteria and clinical guidelines for diagnosis. Neuropathology 23:311–317

    Article  PubMed  Google Scholar 

  92. Yamazaki M, Hashimoto T, Nagasao J, Mori O, Tsuchiya K, Katayama Y, Oyanagi K (2006) Coexistence of both 3- and 4-repeat tau isoforms in glia among tauopathies (abstract). Brain Pathol 16(suppl 1):S48

    Google Scholar 

  93. Zhukareva V, Shah K, Uryu K, Braak H, Del Tredici K, Sundarraj S, Clark C, Trojanowski JQ, Lee VM (2002) Biochemical analysis of tau proteins in argyrophilic grain disease, Alzheimer’s disease, and Pick’s disease: a comparative study. Am J Pathol 161:1135–1141

    CAS  PubMed  Google Scholar 

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Acknowledgments

The author thanks Mrs. V. Rappelsberger for excellent laboratory work, Mr. E. Mitter-Ferstl, PhD, for secretarial and computer work, and Mr. D.W. Dickson, MD, Mayo Clinic, Jacksonville, FL, USA, for valuable advice.

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  1. Institute of Clinical Neurobiology, 18, Kenyongasse, 1070, Vienna, Austria

    K. A. Jellinger

  2. Department of Pathology, OWS Hospital (JA), Vienna, Austria

    J. Attems

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Correspondence to K. A. Jellinger.

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Jellinger, K.A., Attems, J. Neurofibrillary tangle-predominant dementia: comparison with classical Alzheimer disease. Acta Neuropathol 113, 107–117 (2007). https://doi.org/10.1007/s00401-006-0156-7

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  • DOI: https://doi.org/10.1007/s00401-006-0156-7

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