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Pigmented astrocytoma with suprasellar location: case report and literature review

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Abstract

A large suprasellar, partly cystic, contrast-enhancing tumor was resected from a 19-year-old woman who presented with bitemporal visual field defects and reduced visual acuity. Grossly, the tumor was brown and located in the subarachnoid space. Histologically, it was composed of spindle and pleomorphic cells, including giant tumor cells, with markedly pleomorphic nuclei. Reticulin fibers surrounded single cells and small groups of cells. Very few mitotic figures were found in the tumor, and no necrosis or microvascular proliferation was seen. The tumor thereby resembled a pleomorphic xanthoastrocytoma. Many of the tumor cells contained a dark-brown intracytoplasmic pigment, shown to be melanosomal melanin by ultrastructural examination. Immunohistochemical examination demonstrated that the pigment was present in glial tumor cells. Only four cases of pigmented astrocytic tumors have been published, none of these were suprasellar. Our patient received fractionated radiotherapy with a total dose of 48.6 Gy 14 months after gross total removal of the tumor. She is alive without relapse after 12-year follow-up.

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References

  1. Arita K, Kurisu K, Tominaga A, Sugiyama K, Sumida M, Hirose T (2002) Intrasellar pleomorphic xanthoastrocytoma: case report. Neurosurgery 51:1079–1082

    Article  PubMed  Google Scholar 

  2. Barden H (1979) Acid fast staining of oxidized neuromelanin and lipofuscin in the human brain. J Neuropathol Exp Neurol 38:453–462

    Google Scholar 

  3. Baylac F, Martinoli A, Marie B, Bracard S, Marchal JC, Sommelet D, Hassoun J, Plenat F (1997) Une variete exceptionelle de medulloblastome: le medulloblastome melanotique. Ann Pathol 17:403–405

    CAS  PubMed  Google Scholar 

  4. Best PV (1973) A medulloblastoma-like tumour with melanin formation. J Pathol 110:109–111

    CAS  PubMed  Google Scholar 

  5. Boesel CP, Suhan JP (1979) A pigmented choroid plexus carcinoma: histochemical and ultrastructural studies. J Neuropathol Exp Neurol 38:177–186

    Google Scholar 

  6. Boesel CP, Suhan JP, Sayers MP (1978) Melanotic medulloblastoma. Report of a case with ultrastructural findings. J Neuropathol Exp Neurol 37:531–543

    CAS  PubMed  Google Scholar 

  7. Burger PC, Scheithauer BW (1994) Atlas of tumor pathology. Tumors of the central nervous system. Armed Forces Institute of Pathology, Washington

  8. Chan ACL, Ho LC, Yip WWL, Cheung FC (2003) Pigmented ependymoma with lipofuscin and neuromelanin production. Arch Pathol Lab Med 127:872–875

    PubMed  Google Scholar 

  9. Dickersin GR (2000) Diagnostic electron microscopy. A text/atlas, 2nd edn. Springer, New York Berlin Heidelberg

  10. Dolman CL (1988) Melanotic medulloblastoma. Acta Neuropathol 76:528–531

    CAS  PubMed  Google Scholar 

  11. Dooling EC, Chi JG, Gilles FH (1977) Melanotic neuroectodermal tumor of infancy: its histological similarities to fetal pineal gland. Cancer 39:1535–1541

    CAS  PubMed  Google Scholar 

  12. Erdelyi E, VandenBerg SR, Raese J, Barchas JD, Rubinstein LJ, Herman MM (1981) Neural differentiation in the OTT-6050 mouse teratoma: enzymatic and immunofluorescence characterization of a tumor fraction showing melanogenesis in neuroepithelial cells. Virchows Arch 393:27–37

    CAS  Google Scholar 

  13. Gibson JB, Burrows D, Weir WP (1957) Primary melanoma of the meninges. J Pathol Bacteriol 74:419–438

    Google Scholar 

  14. Heyerdahl Strøm E, Skullerud K (1983) Pleomorphic xanthoastrocytoma: report of 5 cases. Clin Neuropathol 2:188–191

    PubMed  Google Scholar 

  15. Hirano A (1997) Neurons and astrocytes. In: Davis RL, Robertson DM (eds) Textbook of neuropathology, 3rd edn. Williams and Wilkins, Baltimore, pp 1–109

  16. Ironside JW, Moss TH, Louis DN, Lowe JS, Weller RO (2002) Diagnostic patology of nervous system tumours. Churchill Livingstone, Edinburgh

  17. Jellinger K, Chou P, Paulus W (2000) Melanocytic lesions. In: Kleihues P, Cavenee WK (eds) World Health Organization classification of tumours. Pathology and genetics of tumours of the nervous system. IARC Press, Lyon, pp 193–195

  18. Kalimo H, Haapasalo H (2000) Melanotic medulloblastoma. In: Kleihues P, Cavenee WK (eds) Pathology and genetics of tumours of the nervous system. IARC Press, Lyon, p 140

  19. Kanzawa T, Takahashi H, Hayano M, Mori S, Shimbo Y, Kitazawa T (1997) Melanotic cerebral astrocytoma: case report and literature review. Acta Neuropathol 93:200–204

    Article  CAS  PubMed  Google Scholar 

  20. Kapur RP, Bigler SA, Skelly M, Gown AM (1992) Anti-melanoma monoclonal antibody HMB45 identified an oncofetal glycoconjugate associated with immature melanosomes. J Histochem Cytochem 40:207–212

    CAS  PubMed  Google Scholar 

  21. Kepes JJ (1982) Meningiomas: biology, pathology and differential diagnosis. Masson, New York

  22. Kepes JJ, Rubinstein LJ, Eng LF (1979) Pleomorphic xanthoastrocytoma: a distinctive meningocerebral glioma of young subjects with a relatively favourable prognosis. Cancer 44:1839–1852

    CAS  PubMed  Google Scholar 

  23. Kepes JJ, Louis DN, Giannini C, Paulus W (2000) Pleomorphic xanthoastrocytoma. In: Kleinhues P, Cavenee WK (eds) World Health Organization classification of tumours. Pathology and genetics of tumours of the nervous system. IARC Press, Lyon, pp 52–54

  24. Kleihues P, Cavenee WK (eds) (2000) World Health Organization classification of tumours. Pathology and genetics of tumours of the nervous system. IARC Press, Lyon

  25. Kleihues P, Burger PC, Scheithauer BW (1993) World Health Organization International Classification of tumours. Histological typing of tumours of the central nervous system, 2nd edn. Springer, Berlin Heidelberg New York

  26. Kros JM, Vecht CJ, Stefanko SZ (1991) The pleomorphic xanthoastrocytoma and its differential diagnosis: A study of five cases. Hum Pathol 22:1128–1135

    Article  CAS  PubMed  Google Scholar 

  27. Lana-Peixoto MA, Lagos J, Silbert SW (1977) Primary pigmented carcinoma of the choroid plexus. A light and electron microscopic study. J Neurosurg 47:442–450

    Google Scholar 

  28. McCloskey JJ, Parker JC Jr, Brooks WH, Blacker HM (1976) Melanin as a component of cerebral gliomas: the melanotic cerebral ependymoma. Cancer 37:2373–2379

    CAS  PubMed  Google Scholar 

  29. Mund ML, Rodrigues MM (1979) Embryology of the human retinal pigment epithelium. In: Zinn KM, Marmor MF (eds) The retinal pigment epithelium. Harvard University Press, Cambridge, pp 45–52

  30. Ng TH, Wong AY, Boadle R, Compton JS (1999) Pigmented central neurocytoma. Am J Surg Pathol 23:1136–1140

    Article  CAS  PubMed  Google Scholar 

  31. Ogata A, Fujioka Y, Nagashima K, Tashiro K, Aida T, Abe H (1989) Malignant melanotic neuroectodermal tumor arising from the pineal body. Acta Neuropathol 77:654–658

    CAS  PubMed  Google Scholar 

  32. Raisanen J, Vogel H, Horoupian DS (1990) Primitive pineal tumor with retinoblastomatous and retinal/ciliary epithelial differentiation: an immunohistochemical study. J Neurooncol 9:165–170

    CAS  PubMed  Google Scholar 

  33. Reimund EL, Sitton JE, Harkin JC (1990) Pigmented choroid plexus papilloma. Arch Pathol Lab Med 114:902–905

    Google Scholar 

  34. Rosenblum MK, Erlandson RA, Aleksic SN, Budzilovich GN (1990) Melanotic ependymoma and subependymoma. Am J Surg Pathol 14:729–736

    CAS  PubMed  Google Scholar 

  35. Schmidbauer M, Budka H, Pilz P (1989) Neuroepithelial and ectomesenchymal differentiation in a primitive pineal tumor (“pineal anlage tumor”). Clin Neuropathol 8:7–10

    Google Scholar 

  36. Seiji M, Fitzpatrick TB, Birbeck MSC (1961) The melanosome: a distinctive subcellular particle of mammalian melanocytes and the site of melanogenesis. J Invest Dermatol 36:243

    CAS  PubMed  Google Scholar 

  37. Sharma MC, Gaikwad S, Mahapatra AK, Jain AK, Sarkar C (1998) Pigmented medulloepithelioma: case report and review of literature. Childs Nerv Syst 14:74–78

    Article  CAS  PubMed  Google Scholar 

  38. Sharma MC, Sarkar C, Gaikwad S, Sharma C, Singh VP (1999) Choroid plexus papilloma: a clinicopathological study of 23 cases. Surg Neurol 52:37–39

    Article  PubMed  Google Scholar 

  39. Sharma MC, Arora R, Khanna N, Singh VP, Sarkar C (2001) Pigmented pleomorphic xanthoastrocytoma. Report of a rare case with review of the literature. Arch Pathol Lab Med 125:808–811

    Google Scholar 

  40. Sharma MC, Agarwal M, Suri A, Gaikwad S, Mukhopadhyay P, Sarkar C (2002) A melanotic desmoplastic medulloblastoma: report of a rare case and review of the literature. Brain Tumor Pathol 19:93–96

    CAS  PubMed  Google Scholar 

  41. Soffer D, Lach B, Constantini S (1992) Melanotic cerebral ganglioglioma: evidence for melanogenesis in neoplastic astrocytes. Acta Neuropathol 83:315–323

    CAS  PubMed  Google Scholar 

  42. Torp SH, Granli US (2001) Proliferative activity in human glioblastomas assessed by various techniques. APMIS 109:865–869

    CAS  PubMed  Google Scholar 

  43. Vajtai I, Yonekawa Y, Schäuble B, Paulus W (1996) Melanotic astrocytoma. Acta Neuropathol 91:549–553

    Article  CAS  PubMed  Google Scholar 

  44. Van den Berg SR, Hess JR, Herman MM, DeArmond SJ, Halks-Miller M, Rubinstein LJ (1981) Neural differentiation in the OTT-6050 mouse teratoma. Virchows Arch 392:295–308

    Google Scholar 

  45. Watanabe K, Ando Y, Iwanaga H, Ochiai C, Nagai M, Okada K, Watanabe N (1995) Choroid plexus papilloma containing melanin pigment. Clin Neuropathol 14:159–161

    CAS  PubMed  Google Scholar 

  46. Woodruff JM, Kourea HP, Louis DN, Scheithauer BW (2000) Schwannoma. In: Kleihues P, Cavenee WK (eds) World Health Organization classification of tumours. Pathology and genetics of tumours of the nervous system. IARC Press, Lyon, pp 164–166

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Authors and Affiliations

  1. The Gade Institute, Department of Pathology, Haukeland University Hospital, , 5021, Bergen, Norway

    Bård Kronen Krossnes & Sverre Jarl Mørk

  2. Department of Oncology, Institute of Medicine, Haukeland University Hospital, 5021, Bergen, Norway

    Olav Mella

  3. Department of Neurosurgery, Institute of Surgical Sciences, Haukeland University Hospital, 5021, Bergen, Norway

    Knut Wester

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  1. Bård Kronen Krossnes
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  2. Olav Mella
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  4. Sverre Jarl Mørk
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Correspondence to Bård Kronen Krossnes.

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Krossnes, B.K., Mella, O., Wester, K. et al. Pigmented astrocytoma with suprasellar location: case report and literature review. Acta Neuropathol 108, 461–466 (2004). https://doi.org/10.1007/s00401-004-0903-6

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  • DOI: https://doi.org/10.1007/s00401-004-0903-6

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