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Role of NLRP3 inflammasome in the pathogenesis of cardiovascular diseases

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Abstract

NLRP3 inflammasome is a key multiprotein signaling platform that tightly controls inflammatory responses and coordinates antimicrobial host defenses by activating caspase-1 for the subsequent maturation of pro-inflammatory cytokines, IL-1β and IL-18, and induces pyroptosis. The assembly and activation of NLRP3 inflammasome are linked to the pathogenesis of several cardiovascular disease risk factors, such as hypertension and diabetes, and their major consequences—myocardial remodeling. The study of the NLRP3 inflammasome in these cardiovascular disease states may uncover important triggers and endogenous modulators of the disease, and lead to new treatment strategies. This review outlines current insights into NLRP3 inflammasome research associated with cardiovascular diseases and discusses the questions that remain in this field.

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (no. 81370428), research grant of Xinxiang Medical University (nos. 300/505186 and 300/505233), and the Department of Veterans Affairs, Washington, DC.

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Authors and Affiliations

  1. Henan Key Laboratory of Medical Tissue Regeneration, Xinxiang Medical University, Xinxiang, 453003, China

    Dongling Liu, Xiao Li & Xianwei Wang

  2. Department of Epidemiology and Health Statistics, School of Public Health, Xinxiang Medical University, Xinxiang, 453003, China

    Xiang Zeng

  3. Central Arkansas Veterans Healthcare System and the Division of Cardiology, University of Arkansas for Medical Sciences, Little Rock, AR, USA

    Jawahar L. Mehta

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  1. Dongling Liu
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Liu, D., Zeng, X., Li, X. et al. Role of NLRP3 inflammasome in the pathogenesis of cardiovascular diseases. Basic Res Cardiol 113, 5 (2018). https://doi.org/10.1007/s00395-017-0663-9

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