Skip to main content
SpringerLink
Log in

Clinical translation of cardioprotective strategies

Report and recommendations of the Hatter Institute 5th International Workshop on Cardioprotection

  • MEETING REPORT
  • Published:
Basic Research in Cardiology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Aletras AH, Kellman P, Derbyshire JA, Arai AE (2008) ACUT(2)E TSE-SSFP: a hybrid method for T2-weighted imaging of edema in the heart. Magn Reson Med 59:229–235

    Article  PubMed  Google Scholar 

  2. Aletras AH, Tilak GS, Natanzon A, Hsu LY, Gonzalez FM, Hoyt RF Jr, Arai AE (2006) Retrospective determination of the area at risk for reperfused acute myocardial infarction with T2-weighted cardiac magnetic resonance imaging: histopathological and displacement encoding with stimulated echoes (DENSE) functional validations. Circulation 113:1865–1870

    Article  PubMed  Google Scholar 

  3. Ali ZA, Callaghan CJ, Lim E, Ali AA, Nouraei SA, Akthar AM, Boyle JR, Varty K, Kharbanda RK, Dutka DP, Gaunt ME (2007) Remote ischemic preconditioning reduces myocardial and renal injury after elective abdominal aortic aneurysm repair: a randomized controlled trial. Circulation 116:I98–105

    Article  PubMed  Google Scholar 

  4. Apstein CS, Opie LH (2005) A challenge to the metabolic approach to myocardial ischaemia. Eur Heart J 26:956–959

    Article  PubMed  Google Scholar 

  5. Bates E, Bode C, Costa M, Gibson CM, Granger C, Green C, Grimes K, Harrington R, Huber K, Kleiman N, Mochly-Rosen D, Roe M, Sadowski Z, Solomon S, Widimsky P (2008) Intracoronary KAI-9803 as an adjunct to primary percutaneous coronary intervention for acute ST-segment elevation myocardial infarction. Circulation 117:886–896

    Article  PubMed  Google Scholar 

  6. Baxter GF, Yellon DM (2003) Current trends and controversies in ischemia-reperfusion research–meeting report of the Hatter institute 3rd international workshop on cardioprotection. Basic Res Cardiol 98:133–136

    Article  PubMed  Google Scholar 

  7. Belonje AM, Voors AA, van Gilst WH, Anker SD, Slart RH, Tio RA, Zijlstra F, van Veldhuisen DJ (2008) Effects of erythropoietin after an acute myocardial infarction: rationale and study design of a prospective, randomized, clinical trial (HEBE III). Am Heart J 155:817–822

    Article  PubMed  CAS  Google Scholar 

  8. Boengler K, Buechert A, Heinen Y, Roeskes C, Hilfiker-Kleiner D, Heusch G, Schulz R (2008) Cardioprotection by ischemic postconditioning is lost in aged and STAT3-deficient mice. Circ Res 102:131–135

    Article  PubMed  CAS  Google Scholar 

  9. Bolli R, Becker L, Gross G, Mentzer R Jr, Balshaw D, Lathrop DA (2004) Myocardial protection at a crossroads: the need for translation into clinical therapy. Circ Res 95:125–134

    Article  PubMed  CAS  Google Scholar 

  10. Bose AK, Mocanu MM, Carr RD, Yellon DM (2005) Glucagon like peptide-1 is protective against myocardial ischemia/reperfusion injury when given either as a preconditioning mimetic or at reperfusion in an isolated rat heart model. Cardiovasc Drugs Ther 19:9–11

    Article  PubMed  Google Scholar 

  11. Burley DS, Hamid SA, Baxter GF (2007) Cardioprotective actions of peptide hormones in myocardial ischemia. Heart Fail Rev 12:279–291

    Article  PubMed  CAS  Google Scholar 

  12. Cheung MM, Kharbanda RK, Konstantinov IE, Shimizu M, Frndova H, Li J, Holtby HM, Cox PN, Smallhorn JF, Van Arsdell GS, Redington AN (2006) Randomized controlled trial of the effects of remote ischemic preconditioning on children undergoing cardiac surgery: first clinical application in humans. J Am Coll Cardiol 47:2277–2282

    Article  PubMed  Google Scholar 

  13. Cohen MV, Downey JM (2008) Adenosine: trigger and mediator of cardioprotection. Basic Res Cardiol 103:203–215

    Article  PubMed  CAS  Google Scholar 

  14. Ferdinandy P, Schulz R, Baxter GF (2007) Interaction of cardiovascular risk factors with myocardial ischemia/reperfusion injury, preconditioning, and postconditioning. Pharmacol Rev 59:418–458

    Article  PubMed  CAS  Google Scholar 

  15. Forster K, Paul I, Solenkova N, Staudt A, Cohen MV, Downey JM, Felix SB, Krieg T (2006) NECA at reperfusion limits infarction and inhibits formation of the mitochondrial permeability transition pore by activating p70S6 kinase. Basic Res Cardiol 101:319–326

    Article  PubMed  Google Scholar 

  16. Fuglesteg BN, Suleman N, Tiron C, Kanhema T, Lacerda L, Andreasen TV, Sack MN, Jonassen AK, Mjos OD, Opie LH, Lecour S (2008) Signal transducer and activator of transcription 3 is involved in the cardioprotective signalling pathway activated by insulin therapy at reperfusion. Basic Res Cardiol [Epub ahead of print]

  17. Galie N, Guarnieri C, Ussia GP, Zimarino M, Traini AM, Parlangeli R, Vaona I, Branzi A, Magnani B (1995) Limitation of myocardial infarct size by nicorandil after sustained ischemia in pigs. J Cardiovasc Pharmacol 26:477–484

    Article  PubMed  CAS  Google Scholar 

  18. Gomez L, Thibault H, Gharib A, Dumont JM, Vuagniaux G, Scalfaro P, Derumeaux G, Ovize M (2007) Inhibition of mitochondrial permeability transition improves functional recovery and reduces mortality following acute myocardial infarction in mice. Am J Physiol Heart Circ Physiol 293:H1654–H1661

    Article  PubMed  CAS  Google Scholar 

  19. Hausenloy DJ, Duchen MR, Yellon DM (2003) Inhibiting mitochondrial permeability transition pore opening at reperfusion protects against ischaemia-reperfusion injury. Cardiovasc Res 60:617–625

    Article  PubMed  CAS  Google Scholar 

  20. Hausenloy DJ, Maddock HL, Baxter GF, Yellon DM (2002) Inhibiting mitochondrial permeability transition pore opening: a new paradigm for myocardial preconditioning? Cardiovasc Res 55:534–543

    Article  PubMed  CAS  Google Scholar 

  21. Hausenloy DJ, Mwamure PK, Venugopal V, Harris J, Barnard M, Grundy E, Ashley E, Vichare S, Di Salvo C, Kolvekar S, Hayward M, Keogh B, MacAllister RJ, Yellon DM (2007) Effect of remote ischaemic preconditioning on myocardial injury in patients undergoing coronary artery bypass graft surgery: a randomised controlled trial. Lancet 370:575–579

    Article  PubMed  Google Scholar 

  22. Hausenloy DJ, Yellon DM (2003) The mitochondrial permeability transition pore: its fundamental role in mediating cell death during ischaemia and reperfusion. J Mol Cell Cardiol 35:339–341

    Article  PubMed  CAS  Google Scholar 

  23. Hausenloy DJ, Yellon DM (2004) New directions for protecting the heart against ischaemia-reperfusion injury: targeting the reperfusion injury salvage kinase (RISK)-pathway. Cardiovasc Res 61:448–460

    Article  PubMed  CAS  Google Scholar 

  24. Hausenloy DJ, Yellon DM (2005) Protecting the myocardium at time of reperfusion–meeting report of the Hatter institute 4th international workshop on cardio-protection. Basic Res Cardiol 100:383–386

    Article  PubMed  CAS  Google Scholar 

  25. Hausenloy DJ, Yellon DM (2007a) Preconditioning and postconditioning: united at reperfusion. Pharmacol Ther 116:173–191

    Article  PubMed  CAS  Google Scholar 

  26. Hausenloy DJ, Yellon DM (2007b) Reperfusion injury salvage kinase signalling: taking a RISK for cardioprotection. Heart Fail Rev 12:217–234

    Article  PubMed  CAS  Google Scholar 

  27. Hausenloy DJ, Yellon DM (2008) Remote ischaemic preconditioning: underlying mechanisms and clinical application. Cardiovasc Res May 20. [Epub ahead of print]

  28. Heusch G, Schulz R (2002) Remote preconditioning. J Mol Cell Cardiol 34:1279–1281

    Article  PubMed  CAS  Google Scholar 

  29. Imagawa J, Baxter GF, Yellon DM (1998) Myocardial protection afforded by nicorandil and ischaemic preconditioning in a rabbit infarct model in vivo. J Cardiovasc Pharmacol 31:74–79

    Article  PubMed  CAS  Google Scholar 

  30. Kerendi F, Kin H, Halkos ME, Jiang R, Zatta AJ, Zhao ZQ, Guyton RA, Vinten-Johansen J (2005) Remote postconditioning. Brief renal ischemia and reperfusion applied before coronary artery reperfusion reduces myocardial infarct size via endogenous activation of adenosine receptors. Basic Res Cardiol 100:404–412

    Article  PubMed  CAS  Google Scholar 

  31. Kitakaze M, Asakura M, Kim J, Shintani Y, Asanuma H, Hamasaki T, Seguchi O, Myoishi M, Minamino T, Ohara T, Nagai Y, Nanto S, Watanabe K, Fukuzawa S, Hirayama A, Nakamura N, Kimura K, Fujii K, Ishihara M, Saito Y, Tomoike H, Kitamura S (2007) Human atrial natriuretic peptide and nicorandil as adjuncts to reperfusion treatment for acute myocardial infarction (J-WIND): two randomised trials. Lancet 370:1483–1493

    Article  PubMed  CAS  Google Scholar 

  32. Kloner RA, Forman MB, Gibbons RJ, Ross AM, Alexander RW, Stone GW (2006) Impact of time to therapy and reperfusion modality on the efficacy of adenosine in acute myocardial infarction: the AMISTAD-2 trial. Eur Heart J 27:2400–2405

    Article  PubMed  CAS  Google Scholar 

  33. Kloner RA, Rezkalla SH (2004) Cardiac protection during acute myocardial infarction: where do we stand in 2004? J Am Coll Cardiol 44:276–286

    Article  PubMed  Google Scholar 

  34. Lecour S, Suleman N, Deuchar GA, Somers S, Lacerda L, Huisamen B, Opie LH (2005) Pharmacological preconditioning with tumor necrosis factor-alpha activates signal transducer and activator of transcription-3 at reperfusion without involving classic prosurvival kinases (akt and extracellular signal-regulated kinase). Circulation 112:3911–3918

    Article  PubMed  CAS  Google Scholar 

  35. Lehrke S, Steen H, Sievers HH, Peters H, Opitz A, Muller-Bardorff M, Wiegand UK, Katus HA, Giannitsis E (2004) Cardiac troponin T for prediction of short- and long-term morbidity and mortality after elective open heart surgery. Clin Chem 50:1560–1567

    Article  PubMed  CAS  Google Scholar 

  36. Mahaffey KW, Puma JA, Barbagelata NA, DiCarli MF, Leesar MA, Browne KF, Eisenberg PR, Bolli R, Casas AC, Molina-Viamonte V, Orlandi C, Blevins R, Gibbons RJ, Califf RM, Granger CB (1999) Adenosine as an adjunct to thrombolytic therapy for acute myocardial infarction: results of a multicenter, randomized, placebo-controlled trial: the acute myocardial infarction study of adenosine (AMISTAD) trial. J Am Coll Cardiol 34:1711–1720

    Article  PubMed  CAS  Google Scholar 

  37. Mehta SR, Yusuf S, Diaz R, Zhu J, Pais P, Xavier D, Paolasso E, Ahmed R, Xie C, Kazmi K, Tai J, Orlandini A, Pogue J, Liu L (2005) Effect of glucose-insulin-potassium infusion on mortality in patients with acute ST-segment elevation myocardial infarction: the CREATE-ECLA randomized controlled trial. JAMA 293:437–446

    Article  PubMed  Google Scholar 

  38. Miki T, Miura T, Tanno M, Nishihara M, Naitoh K, Sato T, Takahashi A, Shimamoto K (2007) Impairment of cardioprotective PI3K-Akt signaling by post-infarct ventricular remodeling is compensated by an ERK-mediated pathway. Basic Res Cardiol 102:163–170

    Article  PubMed  CAS  Google Scholar 

  39. Ndrepepa G, Mehilli J, Schwaiger M, Schuhlen H, Nekolla S, Martinoff S, Schmitt C, Dirschinger J, Schomig A, Kastrati A (2004) Prognostic value of myocardial salvage achieved by reperfusion therapy in patients with acute myocardial infarction. J Nucl Med 45:725–729

    PubMed  Google Scholar 

  40. Nikolaidis LA, Mankad S, Sokos GG, Miske G, Shah A, Elahi D, Shannon RP (2004) Effects of glucagon-like peptide-1 in patients with acute myocardial infarction and left ventricular dysfunction after successful reperfusion. Circulation 109:962–965

    Article  PubMed  CAS  Google Scholar 

  41. O’Neill WW (2003) Cooling as an adjunct to primary PCI for myocardial infarction. Transcatheter cardiovascular therapeutics conference

  42. Przyklenk K, Bauer B, Ovize M, Kloner RA, Whittaker P (1993) Regional ischemic ‘preconditioning’ protects remote virgin myocardium from subsequent sustained coronary occlusion. Circulation 87:893–899

    PubMed  CAS  Google Scholar 

  43. Riksen NP, Hausenloy DJ, Yellon DM (2008) Erythropoietin: ready for prime-time cardioprotection. Trends Pharmacol Sci 29:258–267

    Article  PubMed  CAS  Google Scholar 

  44. Riksen NP, Rongen GA, Yellon D, Smits P (2008) Human in vivo research on the vascular effects of adenosine. Eur J Pharmacol 585:220–227

    Article  PubMed  CAS  Google Scholar 

  45. Ross AM, Gibbons RJ, Stone GW, Kloner RA, Alexander RW (2005) A randomized, double-blinded, placebo-controlled multicenter trial of adenosine as an adjunct to reperfusion in the treatment of acute myocardial infarction (AMISTAD-II). J Am Coll Cardiol 45:1775–1780

    Article  PubMed  CAS  Google Scholar 

  46. Skyschally A, Leineweber K, Gres P, Haude M, Erbel R, Heusch G (2006) Coronary microembolization. Basic Res Cardiol 101:373–382

    Article  PubMed  Google Scholar 

  47. Staat P, Rioufol G, Piot C, Cottin Y, Cung TT, L’Huillier I, Aupetit JF, Bonnefoy E, Finet G, Andre-Fouet X, Ovize M (2005) Postconditioning the human heart. Circulation 112:2143–2148

    Article  PubMed  Google Scholar 

  48. Thibault H, Piot C, Staat P, Bontemps L, Sportouch C, Rioufol G, Cung TT, Bonnefoy E, Angoulvant D, Aupetit JF, Finet G, Andre-Fouet X, Macia JC, Raczka F, Rossi R, Itti R, Kirkorian G, Derumeaux G, Ovize M (2008) Long-term benefit of postconditioning. Circulation 117:1037–1044

    Article  PubMed  CAS  Google Scholar 

  49. Warda HM, Bax JJ, Bosch JG, Atsma DE, Jukema JW, van der Wall EE, van der LA, Schalij MJ, Oemrawsingh PV (2005) Effect of intracoronary aqueous oxygen on left ventricular remodeling after anterior wall ST-elevation acute myocardial infarction. Am J Cardiol 96:22–24

    Article  PubMed  Google Scholar 

  50. Yang XM, Philipp S, Downey JM, Cohen MV (2006) Atrial natriuretic peptide administered just prior to reperfusion limits infarction in rabbit hearts. Basic Res Cardiol 101:311–318

    Article  PubMed  CAS  Google Scholar 

  51. Yellon DM, Hausenloy DJ (2007) Myocardial reperfusion injury. N Engl J Med 357:1121–1135

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. The Hatter Institute and Center for Cardiology, University College London Hospitals and Medical School, Grafton Way, London, WC1E 6DB, UK

    Derek J. Hausenloy &  Derek M. Yellon

Authors
  1. Derek J. Hausenloy
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Derek M. Yellon
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Derek M. Yellon.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hausenloy, D.J., Yellon, D.M. Clinical translation of cardioprotective strategies. Basic Res Cardiol 103, 493–500 (2008). https://doi.org/10.1007/s00395-008-0736-x

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00395-008-0736-x

Keywords

Search

Navigation