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Ilex paraguariensis (yerba mate) improves endocrine and metabolic disorders in obese rats primed by early weaning

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Abstract

Purpose

We showed that early weaned rats developed obesity, hyperleptinemia, leptin and insulin resistance at adulthood. Here, we studied the potential beneficial effects of Ilex paraguariensis aqueous solution upon body composition, glycemia, lipid and hormonal profiles, leptin signaling and NPY content.

Methods

To induce early weaning, lactating rats’ teats were blocked with a bandage to interrupt lactation during the last 3 days (EW group), while control offspring had free access to milk throughout lactation (C group). In postnatal day (PN) 150, EW offspring were subdivided into: EW and EW+ mate groups treated, respectively, with water or yerba mate aqueous solution (1 g/kg BW/day, gavage) during 30 days. C offspring received water for gavage. In PN180, offspring were killed.

Results

EW+ mate group presented lower body weight (−10 %), adipose mass (retroperitoneal:−40 % and epididymal:−44 %), total body fat (−43 %), subcutaneous fat (−46 %), visceral adipocyte area (−21 %), triglyceridemia (−31 %) and hypothalamic NPY content (−37 %) compared to EW group. However, hyperglycemia and lower HDL-c levels observed in EW group were not reverted with mate treatment. Although the hyperleptinemia, lower hypothalamic JAK2 and pSTAT3 content of EW group were not corrected by mate treatment, the hyperphagia and higher hypothalamic SOCS-3 content were normalized in EW+ mate group, indicating that the central leptin resistance could be restored.

Conclusion

Thus, the therapy with yerba mate solution was capable to reverse abdominal obesity, leptin resistance and hypertriglyceridemia, suggesting an important role of this bioactive component in the management of obesity in this programming model.

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Acknowledgments

All authors are grateful to Miss Monica Moura and Mr. Ulisses Risso Siqueira for technical assistance as well as to Mr. José Firmino Nogueira Neto for lipid profile analysis (LabLip – State University of Rio de Janeiro). NS Lima, JG Franco and LA Maia participated in collection, analysis and interpretation of data. A Kaezer and I Felzenszwalb were responsible for mate treatment; N Peixoto-Silva was responsible for adipocyte morphometry; EG Moura, E Oliveira and PC Lisboa were responsible for conception and design, and also performed drafting and critical revising of the manuscript. This research was supported by Conselho Nacional de Desenvolvimento Científico e Tecnológico—CNPq (National Council for Scientific and Technological Development), Coordenacão de Aperfeiçoamento de Pessoal de Nível Superior—CAPES (Coordination for the Enhancement of Higher Education Personnel) and Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro—FAPERJ (Carlos Chagas Filho Research Foundation of the State of Rio de Janeiro).

Conflict of interest

On behalf of all authors, the corresponding author states that there is no conflict of interest.

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Authors and Affiliations

  1. Laboratory of Endocrine Physiology, Department of Physiological Sciences, Roberto Alcantara Gomes Biology Institute, State University of Rio de Janeiro, Rio de Janeiro, RJ, 20551-030, Brazil

    Natália da S. Lima, Juliana G. Franco, Nayara Peixoto-Silva, Lígia A. Maia, Andrea Kaezer, Elaine de Oliveira, Egberto G. de Moura & Patricia Cristina Lisboa

  2. Department of Biophysics and Biometry, Roberto Alcantara Gomes Biology Institute, State University of Rio de Janeiro, Rio de Janeiro, RJ, 20551-030, Brazil

    Andrea Kaezer & Israel Felzenszwalb

  3. Departamento de Ciências Fisiológicas, 5° andar, Instituto de Biologia, Universidade do Estado do Rio de Janeiro, Av. 28 de setembro, 87, Rio de Janeiro, RJ, 20551-030, Brazil

    Patricia Cristina Lisboa

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  1. Natália da S. Lima
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  2. Juliana G. Franco
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  3. Nayara Peixoto-Silva
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  4. Lígia A. Maia
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Correspondence to Patricia Cristina Lisboa.

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Lima, N.d.S., Franco, J.G., Peixoto-Silva, N. et al. Ilex paraguariensis (yerba mate) improves endocrine and metabolic disorders in obese rats primed by early weaning. Eur J Nutr 53, 73–82 (2014). https://doi.org/10.1007/s00394-013-0500-3

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  • DOI: https://doi.org/10.1007/s00394-013-0500-3

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