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Adipocyte fatty acid binding protein during refeeding of female patients with anorexia nervosa

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Abstract

Background

Adipocyte fatty acid binding protein (A-FABP) has been suggested to play an important role in fat metabolism linking obesity and the metabolic syndrome. Increasing A-FABP plasma levels were observed during greatest weight loss after bariatric surgery suggesting that A-FABP may indicate changes in fat mass in dynamic situations.

Aim of the study

As there are no data on weight gain, we investigated the effect of refeeding anorexic patients on body composition and A-FABP plasma levels.

Methods

Parameters of glucose and lipid metabolism as well as plasma levels of leptin and A-FABP were prospectively assessed in 16 female patients with anorexia nervosa during inpatient weight restoration. Body composition was determined by multifrequency body impedance analysis.

Results

After 28 days, fat mass increased from 4.4 ± 2.5 kg at baseline to 5.5 ± 2.2 kg (P < 0.01), constituting 40% of total weight gain. Conversely, A-FABP concentrations decreased from 32.56 ± 35.59 ng/ml at baseline to 21.27 ± 13.68 ng/ml (P < 0.05), which corresponds to a significant decrease in the proportion of A-FABP per kilogram fat mass from 7.86 ± 5.23 to 4.09 ± 2.12 ng/ml/kg (P ≤ 0.001). Variation in A-FABP plasma concentration was predictive for changes in total cholesterol levels (adjusted r 2 = 0.239; P ≤ 0.05), but not for gain in weight, fat mass, or percent body fat.

Conclusion

The present results indicate that variation in A-FABP plasma levels reflect alterations in nutritional status in patients with anorexia nervosa.

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References

  1. Bosy-Westphal A, Brabant G, Haas V, Onur S, Paul T, Nutzinger D, Klein H, Hauer M, Muller MJ (2005) Determinants of plasma adiponectin levels in patients with anorexia nervosa examined before and after weight gain. Eur J Nutr 44:355–359

    Article  CAS  Google Scholar 

  2. Casanueva FF, Dieguez C, Popovic V, Peino R, Considine RV, Caro JF (1997) Serum immunoreactive leptin concentrations in patients with anorexia nervosa before and after partial weight recovery. Biochem Mol Med 60:116–120

    Article  CAS  Google Scholar 

  3. Casper RC (1996) Carbohydrate metabolism and its regulatory hormones in anorexia nervosa. Psychiatry Res 62:85–96

    Article  CAS  Google Scholar 

  4. Coe NR, Bernlohr DA (1998) Physiological properties and functions of intracellular fatty acid-binding proteins. Biochim Biophys Acta 1391:287–306

    CAS  Google Scholar 

  5. Davis C, Katzman DK, Kaptein S, Kirsh C, Brewer H, Kalmbach K, Olmsted MP, Woodside DB, Kaplan AS (1997) The prevalence of high-level exercise in the eating disorders: etiological implications. Compr Psychiatry 38:321–326

    Article  CAS  Google Scholar 

  6. Engl J, Ciardi C, Tatarczyk T, Kaser S, Laimer M, Laimer E, Weiss H, Aigner F, Molnar C, Tilg H, Patsch JR, Ebenbichler CF (2008) A-FABP—a biomarker associated with the metabolic syndrome and/or an indicator of weight change? Obesity (Silver Spring) 16:1838–1842

    Article  CAS  Google Scholar 

  7. Forbes GB, Kreipe RE, Lipinski BA, Hodgman CH (1984) Body composition changes during recovery from anorexia nervosa: comparison of two dietary regimes. Am J Clin Nutr 40:1137–1145

    CAS  Google Scholar 

  8. Grinspoon S, Gulick T, Askari H, Landt M, Lee K, Anderson E, Ma Z, Vignati L, Bowsher R, Herzog D, Klibanski A (1996) Serum leptin levels in women with anorexia nervosa. J Clin Endocrinol Metab 81:3861–3863

    Article  CAS  Google Scholar 

  9. Grinspoon S, Thomas L, Miller K, Pitts S, Herzog D, Klibanski A (2001) Changes in regional fat redistribution and the effects of estrogen during spontaneous weight gain in women with anorexia nervosa. Am J Clin Nutr 73:865–869

    CAS  Google Scholar 

  10. Gross G, Russell JD, Beumont PJ, Touyz SW, Roach P, Aslani A, Hansen RD, Allen BJ (2000) Longitudinal study of patients with anorexia nervosa 6 to 10 years after treatment. Impact of adequate weight restoration on outcome. Ann NY Acad Sci 904:614–616

    Article  CAS  Google Scholar 

  11. Haider DG, Schindler K, Bohdjalian A, Prager G, Luger A, Wolzt M, Ludvik B (2007) Plasma adipocyte and epidermal fatty acid binding protein is reduced after weight loss in obesity. Diabetes Obes Metab 9:761–763

    Article  CAS  Google Scholar 

  12. Large V, Peroni O, Letexier D, Ray H, Beylot M (2004) Metabolism of lipids in human white adipocyte. Diabetes Metab 30:294–309

    Article  CAS  Google Scholar 

  13. Makowski L, Hotamisligil GS (2004) Fatty acid binding proteins—the evolutionary crossroads of inflammatory and metabolic responses. J Nutr 134:2464S–2468S

    CAS  Google Scholar 

  14. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC (1985) Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28:412–419

    Article  CAS  Google Scholar 

  15. Misra M, Miller KK, Almazan C, Ramaswamy K, Aggarwal A, Herzog DB, Neubauer G, Breu J, Klibanski A (2004) Hormonal and body composition predictors of soluble leptin receptor, leptin, and free leptin index in adolescent girls with anorexia nervosa and controls and relation to insulin sensitivity. J Clin Endocrinol Metab 89:3486–3495

    Article  CAS  Google Scholar 

  16. Misra M, Soyka LA, Miller KK, Grinspoon S, Levitsky LL, Klibanski A (2003) Regional body composition in adolescents with anorexia nervosa and changes with weight recovery. Am J Clin Nutr 77:1361–1367

    CAS  Google Scholar 

  17. Modan-Moses D, Stein D, Pariente C, Yaroslavsky A, Ram A, Faigin M, Loewenthal R, Yissachar E, Hemi R, Kanety H (2007) Modulation of adiponectin and leptin during refeeding of female anorexia nervosa patients. J Clin Endocrinol Metab 92:1843–1847

    Article  CAS  Google Scholar 

  18. Orphanidou CI, McCargar LJ, Birmingham CL, Belzberg AS (1997) Changes in body composition and fat distribution after short-term weight gain in patients with anorexia nervosa. Am J Clin Nutr 65:1034–1041

    CAS  Google Scholar 

  19. Polito A, Cuzzolaro M, Raguzzini A, Censi L, Ferro-Luzzi A (1998) Body composition changes in anorexia nervosa. Eur J Clin Nutr 52:655–662

    Article  CAS  Google Scholar 

  20. Probst M, Goris M, Vandereycken W, Van Coppenolle H (1996) Body composition in female anorexia nervosa patients. Br J Nutr 76:639–647

    Article  CAS  Google Scholar 

  21. Probst M, Goris M, Vandereycken W, Van Coppenolle H (2001) Body composition of anorexia nervosa patients assessed by underwater weighing and skinfold-thickness measurements before and after weight gain. Am J Clin Nutr 73:190–197

    CAS  Google Scholar 

  22. Scalfi L, Marra M, Caldara A, Silvestri E, Contaldo F (1999) Changes in bioimpedance analysis after stable refeeding of undernourished anorexic patients. Int J Obes Relat Metab Disord 23:133–137

    Article  CAS  Google Scholar 

  23. Scalfi L, Polito A, Bianchi L, Marra M, Caldara A, Nicolai E, Contaldo F (2002) Body composition changes in patients with anorexia nervosa after complete weight recovery. Eur J Clin Nutr 56:15–20

    Article  CAS  Google Scholar 

  24. Schwartz MW, Woods SC, Porte D Jr, Seeley RJ, Baskin DG (2000) Central nervous system control of food intake. Nature 404:661–671

    CAS  Google Scholar 

  25. Seeley RJ, van Dijk G, Campfield LA, Smith FJ, Burn P, Nelligan JA, Bell SM, Baskin DG, Woods SC, Schwartz MW (1996) Intraventricular leptin reduces food intake and body weight of lean rats but not obese Zucker rats. Horm Metab Res 28:664–668

    Article  CAS  Google Scholar 

  26. Shen WJ, Liang Y, Hong R, Patel S, Natu V, Sridhar K, Jenkins A, Bernlohr DA, Kraemer FB (2001) Characterization of the functional interaction of adipocyte lipid-binding protein with hormone-sensitive lipase. J Biol Chem 276:49443–49448

    Article  CAS  Google Scholar 

  27. Shulman GI (2000) Cellular mechanisms of insulin resistance. J Clin Invest 106:171–176

    Article  CAS  Google Scholar 

  28. Swenne I, Gustafsson J (2004) Endogenous glucose production and lipolysis in anorexia nervosa—a study using stable isotope-labelled compounds. Acta Paediatr 93:1446–1448

    Article  CAS  Google Scholar 

  29. Tagami T, Satoh N, Usui T, Yamada K, Shimatsu A, Kuzuya H (2004) Adiponectin in anorexia nervosa and bulimia nervosa. J Clin Endocrinol Metab 89:1833–1837

    Article  CAS  Google Scholar 

  30. Tschop M, Wawarta R, Riepl RL, Friedrich S, Bidlingmaier M, Landgraf R, Folwaczny C (2001) Post-prandial decrease of circulating human ghrelin levels. J Endocrinol Invest 24:RC19–RC21

    CAS  Google Scholar 

  31. Vaisman N, Corey M, Rossi MF, Goldberg E, Pencharz P (1988) Changes in body composition during refeeding of patients with anorexia nervosa. J Pediatr 113:925–929

    Article  CAS  Google Scholar 

  32. Waller EG, Wade AJ, Treasure J, Ward A, Leonard T, Powell-Tuck J (1996) Physical measures of recovery from anorexia nervosa during hospitalised re-feeding. Eur J Clin Nutr 50:165–170

    CAS  Google Scholar 

  33. Xu A, Tso AW, Cheung BM, Wang Y, Wat NM, Fong CH, Yeung DC, Janus ED, Sham PC, Lam KS (2007) Circulating adipocyte-fatty acid binding protein levels predict the development of the metabolic syndrome: a 5-year prospective study. Circulation 115:1537–1543

    Article  CAS  Google Scholar 

  34. Xu A, Wang Y, Xu JY, Stejskal D, Tam S, Zhang J, Wat NM, Wong WK, Lam KS (2006) Adipocyte fatty acid-binding protein is a plasma biomarker closely associated with obesity and metabolic syndrome. Clin Chem 52:405–413

    Article  CAS  Google Scholar 

  35. Zimmerman AW, Veerkamp JH (2002) New insights into the structure and function of fatty acid-binding proteins. Cell Mol Life Sci 59:1096–1116

    Article  CAS  Google Scholar 

  36. Zimmermann R, Strauss JG, Haemmerle G, Schoiswohl G, Birner-Gruenberger R, Riederer M, Lass A, Neuberger G, Eisenhaber F, Hermetter A, Zechner R (2004) Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase. Science 306:1383–1386

    Article  CAS  Google Scholar 

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Acknowledgment

We thank Karin Salzmann for excellent technical assistance.

Author information

Authors and Affiliations

  1. Department of Internal Medicine I, Medical University Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria

    Julia Engl, Alexander Tschoner, Susanne Kaser, Markus Laimer, Josef R. Patsch & Christoph F. Ebenbichler

  2. Division for Psychosomatic Medicine and Psychosocial Psychiatry, Department of Psychiatry, Medical University Innsbruck, Innsbruck, Austria

    Michael Willis, Ingrid Schuster, Wilfried Biebl & Barbara Mangweth

Authors
  1. Julia Engl
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  2. Alexander Tschoner
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  3. Michael Willis
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  4. Ingrid Schuster
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  5. Susanne Kaser
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  6. Markus Laimer
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  7. Wilfried Biebl
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  8. Josef R. Patsch
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  9. Barbara Mangweth
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  10. Christoph F. Ebenbichler
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Corresponding author

Correspondence to Christoph F. Ebenbichler.

Additional information

J. Engl and A. Tschoner contributed equally to the work.

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Engl, J., Tschoner, A., Willis, M. et al. Adipocyte fatty acid binding protein during refeeding of female patients with anorexia nervosa. Eur J Nutr 48, 403–408 (2009). https://doi.org/10.1007/s00394-009-0027-9

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  • DOI: https://doi.org/10.1007/s00394-009-0027-9

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