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Atherogenic index of plasma may be strong predictor of subclinical atherosclerosis in patients with Behçet disease

Atherogener Plasma-Index könnte ein starker Prädiktor für subklinische Atherosklerose bei Patienten mit M. Behçet sein

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Abstract

Objectives

Behcet’s disease (BD) is a systemic vasculitis characterized by cardiovascular complications. Early diagnosis of these complications can reduce morbidity and mortality. Carotid artery intima–media thickness (cIMT) and the logarithmic value of triglyceride to high density lipoprotein ratio (atherogenic index of plasma, AIP) are good markers of atherosclerosis. The purpose of this study was to investigate whether AIP is a predictive marker of subclinical atherosclerosis in BD patients.

Patients and methods

A total of 84 BD patients (60 male, 24 female) and 84 healthy control individuals (58 male, 26 female) were included in this study. cIMT measurements were made, and AIP values were calculated.

Results

cIMT (p < 0.001) and AIP (p < 0.001) values of the BD patients were higher than those of the control group. A strong independent relationship was found between the AIP value and cIMT (β = 0.232, p = 0.018). In the subgroup analysis, the cIMT and AIP values of male BD patients were higher than those of female BD patients.

Conclusion

Increased AIP and cIMT values can be a good marker for subclinical atherosclerosis in BD patients, especially in male BD patients.

Zusammenfassung

Zielsetzung

Bei Morbus Behçet („Behcet’s disease“, BD) handelt es sich um eine systemische Vaskulitis, die durch kardiovaskuläre Komplikationen charakterisiert ist. Eine frühzeitige Diagnose dieser Komplikationen kann die Morbidität und Mortalität reduzieren. Die Intima-Media-Dicke der A. carotis (cIMT) und der Logarithmus aus dem Quotienten aus Triglyceriden und Lipoproteinen mit hoher Dichte (atherogener Plasma-Index, AIP) sind geeignete Marker für eine Atherosklerose. Ziel dieser Studie war es, zu untersuchen, ob der AIP ein prädiktiver Marker für eine subklinische Atheroskerlose bei BD-Patienten ist.

Patienten und Methoden

Insgesamt 84 BD-Patienten (60 männlich, 24 weiblich) und 84 gesunde Kontrollpersonen (58 männlich, 26 weiblich) wurden in diese Studie eingeschlossen. Es wurden Messungen der cIMT vorgenommen und die AIP-Werte berechnet.

Ergebnisse

Die cIMT- (p < 0,001) und AIP-Werte (p < 0,001) der BD-Patienten waren höher als die der Kontrollgruppe. Es wurde eine starke unabhängige Beziehung zwischen dem AIP- und dem cIMT-Wert festgestellt (β = 0,232, p = 0,018). In der Subgruppenanalyse waren die cIMT- und AIP-Werte der männlichen BD-Patienten höher als die der weiblichen.

Schlussfolgerung

Erhöhte AIP- und cIMT-Werte können einen geeigneten Marker für die subklinische Atherosklerose bei BD-Patienten, insbesondere bei männlichen Patienten, darstellen.

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Author information

Authors and Affiliations

  1. Recep Tayyip Erdogan University, Rize, Turkey

    E. Cure & M. Cumhur Cure

  2. Necmettin Erbakan University, Konya, Turkey

    A. Icli, M. Ozucan & S. Arslan

  3. Eskisehir Military Hospital, Eskisehir, Turkey

    A. Ugur Uslu

  4. Malatya State Hospital, Malatya, Turkey

    R. Aydoğan Baykara & A. Kucuk

  5. Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey

    D. Sakiz

  6. Dogubeyazit Docent Dr Yasar Eryilmaz State Hospital, Agri, Turkey

    F. Yavuz

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  1. E. Cure
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  2. A. Icli
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  4. R. Aydoğan Baykara
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  5. D. Sakiz
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Correspondence to E. Cure.

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Conflict of interest

E. Cure, A. Icli, A. Ugur Uslu, R. Aydoğan Baykara, D. Sakiz, M. Ozucan, F. Yavuz, S. Arslan, M. Cumhur Cure, and A. Kucuk declare that they have no competing interests.

The study was approved by the Ethics Committee of Necmettin Erbakan University, Meram Medical Faculty, and all participants gave written and verbal informed consent consistent with the Helsinki Declaration.

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U. Müller-Ladner, Bad Nauheim

U. Lange, Bad Nauheim

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Cure, E., Icli, A., Ugur Uslu, A. et al. Atherogenic index of plasma may be strong predictor of subclinical atherosclerosis in patients with Behçet disease. Z Rheumatol 76, 259–266 (2017). https://doi.org/10.1007/s00393-016-0141-z

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