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Association of high-sensitivity assayed troponin I with cardiovascular phenotypes in the general population: the population-based Gutenberg health study

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Abstract

Background

Aim of the study was to analyze the correlation of high-sensitivity assayed troponin I with cardiac and vascular structure and function in a large population-based cohort.

Methods

In a sample of 4,139 subjects (2,099 men, 2,040 women, age 35–74 years) from the population-based Gutenberg Health Study, troponin I was measured with a high-sensitivity assay that had a limit of detection of 1.9 pg/mL.

Results

In the study cohort, 3,405 subjects had detectable troponin I concentrations [82.3 % overall, 89.9 % men (N = 1,888), 74.4 % women (N = 1,517)]. All analyses were adjusted for age. The strongest correlate between detectable troponin I and measures of cardiac phenotypes was observed for left ventricular mass (p < 0.001) and left ventricular end-diastolic diameter (p < 0.001) for both, women and men. Left ventricular ejection fraction was inversely correlated with troponin I (p value <0.001 in men and 0.0013 in women), also measures of diastolic dysfunction as represented by Tei index and E/E′ correlated with detectable troponin I concentrations (p < 0.001 for both gender). With respect to vascular structure and function, troponin I correlated with mean intima-media thickness of the carotid artery (p < 0.001 in men and p = 0.013 in women) but showed only borderline correlation with measures of vascular function represented by flow-mediated dilation (p = 0.05 in women and p = 0.018 in men) and arterial stiffness.

Conclusions

Troponin I assessed by a high-sensitivity assay correlated with measures of left ventricular hypertrophy and systolic and diastolic function, whereas its correlation with vascular phenotypes was only of weak magnitude.

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Abbreviations

BMI:

Body mass index

CAD:

Coronary artery disease

CCA:

Common carotid artery

CRP:

C-reactive protein

CV:

Coefficient of variation

eGFR:

Estimated glomerular filtration rate

FMD:

Flow-mediated dilation

GHS:

Gutenberg Health Study

hs-TnI:

Troponin I as measured by a high-sensitivity assay

hs-TnT:

Troponin T as measured by a high-sensitivity assay

LoD:

Limit of detection

LV:

Left ventricular

LVEDD:

Left ventricular end-diastolic diameter

LVEF:

Left ventricular ejection fraction

LVM:

Left ventricular mass

MI:

Myocardial infarction

NT-proBNP:

N-terminal pro-B-type natriuretic peptide

SD:

Standard deviation

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Acknowledgments

The Gutenberg Health Study (GHS) is funded through the government of Rhineland-Palatinate (“Stiftung Rheinland Pfalz für Innovation,” contract No. AZ 961–386261/733), the research programs “Wissen schafft Zukunft” and “Schwerpunkt Vaskuläre Prävention” of the Johannes Gutenberg-University of Mainz, and its contract with Boehringer Ingelheim and Philips Medical Systems, including an unrestricted grant for the GHS.

Conflict of interest

Abbott Diagnostics provided test reagents for high-sensitivity troponin I measurements. Stefan Blankenberg has received honoraria from Abbott Diagnostics, Siemens, Thermo Fisher, and Roche Diagnostics and is a consultant for Thermo Fisher. All other co-authors did not report any conflict of interest.

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Authors and Affiliations

  1. Department of General and Interventional Cardiology, University Heart Center Hamburg, Martinistr. 52, 20246, Hamburg, Germany

    Christoph Sinning, Till Keller, Tanja Zeller, Francisco Ojeda, Michael Schlüter, Renate Schnabel, Edith Lubos, Patrick Diemert & Stefan Blankenberg

  2. Department of Internal Medicine, Federal Armed Forces Central Hospital, Koblenz, Germany

    Christoph Bickel

  3. Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Johannes Gutenberg University, Mainz, Germany

    Karl J. Lackner

  4. Department of Medicine II, University Medical Center, Johannes Gutenberg University Mainz, Langenbeckstr. 1, 55131, Mainz, Germany

    Thomas Munzel & Philipp S. Wild

  5. Center for Thrombosis and Hemostasis, University Medical Center, Johannes Gutenberg University Mainz, Mainz, Germany

    Philipp S. Wild

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Correspondence to Stefan Blankenberg or Philipp S. Wild.

Additional information

C. Sinning and T. Keller contributed equally.

S. Blankenberg and P. S. Wild were both senior authors and contributed equally.

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Sinning, C., Keller, T., Zeller, T. et al. Association of high-sensitivity assayed troponin I with cardiovascular phenotypes in the general population: the population-based Gutenberg health study. Clin Res Cardiol 103, 211–222 (2014). https://doi.org/10.1007/s00392-013-0640-8

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