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Lymphovascular invasion, perineural invasion, and tumor budding are prognostic factors for stage I colon cancer recurrence

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International Journal of Colorectal Disease Aims and scope Submit manuscript

A Correction to this article was published on 04 April 2020

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Abstract

Background

The diagnostic impact of lymphovascular invasion (LVI), perineural invasion (PNI), and tumor budding in stage I colon cancer is currently unknown. This study was conducted to evaluate the prognostic impact of LVI, PNI, and tumor budding in stage I colon cancer.

Methods

From January 2008 to December 2013, 720 patients who underwent curative surgery and were diagnosed with stage I colon cancer were reviewed retrospectively. These patients were categorized into two groups based on LVI, PNI, and tumor budding: the no risk group (n = 566) and risk group (n = 154).

Results

Median follow-up period was 103.5 months, and the 5-year disease-free survival rate of the risk group was significantly lower than that of the no risk group (p = 0.025). In multivariate analysis, only the risk group had prognostic factors for 5-year disease-free survival (p = 0.036). In addition, only differentiation was an independent predictor in the risk group (p = 0.009).

Conclusion

LVI, PNI, and tumor budding are strong prognostic factors for stage I colon cancer. Therefore, patients with positive LVI, PNI, or tumor budding should receive close follow-up and potentially be considered for chemotherapy.

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Change history

  • 04 April 2020

    The name of the author of the original published version of this article was presented incorrectly. The author name <Emphasis Type="Bold">“JungWook Huh”</Emphasis> should have been presented as <Emphasis Type="Bold">“Jung Wook Huh”.</Emphasis>

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Authors and Affiliations

  1. Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, Korea

    Seijong Kim, Jung Wook Huh, Woo Yong Lee, Seong Hyeon Yun, Hee Cheol Kim, Yong Beom Cho, Yoon Ah Park & Jung Kyong Shin

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  1. Seijong Kim
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  2. Jung Wook Huh
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  3. Woo Yong Lee
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  5. Hee Cheol Kim
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  6. Yong Beom Cho
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  7. Yoon Ah Park
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Contributions

Data collection and writing of manuscript are attributed to Seijong Kim. Study proposal, design, analysis, and responsibility to correspondence are attributed to Jung Wook Huh. All authors contributed to the enrollment of patients and approved the final version of the manuscript.

Corresponding author

Correspondence to Jung Wook Huh.

Ethics declarations

The study was approved by the Institutional Review Board of Samsung Medical Center.

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The authors declare that they have no conflict of interest.

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The original version of this article was revised: The name of the author of the original published version of this article was presented incorrectly. The author name “JungWook Huh” should have been presented as “Jung Wook Huh”. This has been correctly presented above.

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Kim, S., Huh, J.W., Lee, W.Y. et al. Lymphovascular invasion, perineural invasion, and tumor budding are prognostic factors for stage I colon cancer recurrence. Int J Colorectal Dis 35, 881–885 (2020). https://doi.org/10.1007/s00384-020-03548-4

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