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Cyclin D1 G870A polymorphism and colorectal cancer susceptibility: a meta-analysis of 20 populations

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International Journal of Colorectal Disease Aims and scope Submit manuscript

Abstract

Purpose

Studies investigating the association between genetic polymorphism of cyclin D1 (CCND1) G870A and risk of colorectal cancer (CRC) reported conflicting results. In order to derive a more precise estimation of the relationship, a meta-analysis was performed.

Materials and methods

We performed an extensive search of relevant studies and carried out a meta-analysis, including 20 studies with 5,975 cases and 8,333 controls, to obtain a more precise estimate.

Results

Overall, significantly elevated colorectal cancer risk was associated with variant allele 870A when all studies were pooled (AA vs. GG: OR = 1.23, 95% CI = 1.04–1.44; GA vs. GG: OR = 1.13, 95% CI = 1.01–1.26; dominant model: OR = 1.16, 95% CI = 1.03–1.31). In the subgroup analysis by ethnicity, significantly increased risks were detected among Caucasians (AA vs. GG: OR = 1.27, 95% CI = 1.04–1.44; dominant model: OR = 1.17, 95% CI = 1.02–1.34).We also observed sporadic CRC with an increased cancer susceptibility (AA vs. GG: OR = 1.24, 95% CI = 1.04–1.48; dominant model: OR = 1.17, 95% CI = 1.04–1.33), when colorectal cancer was stratified into sporadic CRC and hereditary nonpolyposis colorectal cancer (HNPCC). However, no significant associations were found in both Asians and HNPCC patients for all genetic models.

Conclusion

Result suggests that the cyclin D1 870A allele is a low-penetrant risk factor for developing sporadic colorectal cancer, especially among Caucasians.

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Conflict of interest statement

None declared.

Author information

Authors and Affiliations

  1. Department of Medical Oncology, Affiliated Cancer Hospital, Nanjing Medical University, Nanjing, China

    Lou-Qian Zhang

  2. Department of Oncology, Geriatric Institution of Jiangsu Province, Nanjing, China

    Jun Wang & Fu-Yin Liu

  3. Department of Colorectal and Anal Surgery, Cancer Hospital of Jiangsu Province, Nanjing, China

    Jun-Qing Shang, Xin Guan & Jian-Nong Zhou

  4. Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China

    Jian-ling Bai

  5. Department of Oncology, Affiliated Cancer Hospital of Nanjing Medical University, No.140 Han Zhong Road, Nanjing, 210029, China

    Jian-Nong Zhou

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  1. Lou-Qian Zhang
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  2. Jun Wang
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Correspondence to Jian-Nong Zhou.

Additional information

Lou-Qian Zhang and Jun Wang contributed equally to this work and should be considered as co-first authors.

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Zhang, LQ., Wang, J., Shang, JQ. et al. Cyclin D1 G870A polymorphism and colorectal cancer susceptibility: a meta-analysis of 20 populations. Int J Colorectal Dis 26, 1249–1255 (2011). https://doi.org/10.1007/s00384-011-1220-x

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