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Colorectal cancer in a population with endemic Schistosoma mansoni: is this an at-risk population?

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International Journal of Colorectal Disease Aims and scope Submit manuscript

Abstract

Purpose

Chronic infection with schistosomiasis has been clearly associated with the development of bladder cancer, and infestation is associated with a high incidence of colorectal cancer in endemic populations. Despite this association, the potential role of alterations in tumor suppressor genes colorectal cancers has never been evaluated in an endemically infected population. The aim of this paper was to compare histopathologic and genetic changes in schistosomal colitis-associated colorectal cancer (SCC) with colorectal cancer in a group of patients from the same population not affected by the disease (NDCC).

Materials and methods

Sixty patients were included in this study: SCC—40, NDCC—20. Data collected included age, sex, clinical presentation, presence of synchronous tumors, histopathology, and clinical stage. p53, DCC (deleted in colorectal cancer gene), and mismatch repair genes (MLH1 and MSH2) were studied using immunohistochemical staining.

Results

Patients with SCC were significantly younger than the NDCC group (34.52±11.22 years vs 50.73±12.75 years, p=0.02). Mucinous adenocarcinoma occurred significantly more frequently in SCC (35 vs 10%, p=0.02). SCC tumors were more frequently stage III or IV, and significantly more synchronous tumors were present in the affected group (SCC—8/40 vs NDCC—1/20, p=0.05). p53 staining was far more frequent in SCC (SCC—32/40 vs NDCC—8/20, p=0.006). DCC expression was similar in two groups. There were only four cases, three in SCC and one in NDCC, that showed microsatellite instability.

Conclusion

The data suggest that schistosomal colitis is more commonly associated with earlier onset of multicentric colorectal cancer, high percentage of mucinous adenocarcinoma, and presents at an advanced stage. The identification of a higher incidence of altered p53 expression in the SCC group raises the possibility of an association between schistosomiasis and alterations in p53 activation as an inciting event in colorectal cancer development.

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Authors and Affiliations

  1. Department of Surgery, Medical University of Ohio, Dowling Hall, 3065 Arlington Ave., Toledo, OH, 43614-5807, USA

    Anthony J. Senagore

  2. Department of Surgery, Division of Colorectal Surgery, Case Western Reserve University, Cleveland, OH, USA

    Conor P. Delaney & Victor W. Fazio

  3. Department of Surgery, University of Alexandria, Alexandria, Egypt

    Khaled M. Madbouly, Abir Mukerjee, Ahmed M. Hussien, M. A. Shehata & Philippa Navine

Authors
  1. Khaled M. Madbouly
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  2. Anthony J. Senagore
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  3. Abir Mukerjee
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  4. Ahmed M. Hussien
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  5. M. A. Shehata
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  6. Philippa Navine
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  7. Conor P. Delaney
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  8. Victor W. Fazio
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Correspondence to Anthony J. Senagore.

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Madbouly, K.M., Senagore, A.J., Mukerjee, A. et al. Colorectal cancer in a population with endemic Schistosoma mansoni: is this an at-risk population?. Int J Colorectal Dis 22, 175–181 (2007). https://doi.org/10.1007/s00384-006-0144-3

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  • DOI: https://doi.org/10.1007/s00384-006-0144-3

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