Abstract
BACKGROUND AND PURPOSE: In Japan, the incidence of colorectal cancer has increased remarkably since World War II, and interest in this cancer has grown rapidly among Japanese clinicians and pathologists. As a result, the Japanese Society for Cancer of the Colon and Rectum started a multi-institutional registry of colorectal cancer in 1980. The purpose of this report is to present an overview of the actual state of surgical and pathologic aspects of colorectal cancer treated in the leading hospitals in Japan. MATERIALS AND METHODS: Registry files of clinical and pathologic findings for 38,369 patients treated between 1974 and 1986 with five-year follow-up information and 26,360 patients treated between 1991 and 1994 with no follow-up information were reviewed. RESULTS: Numbers of registered patients have increased annually, reflecting a trend toward an increasing incidence of this cancer in Japan. Colon cancer increased more than rectal cancer in both genders. Resection of the primary lesion was achieved in more than 97 percent of patients who underwent surgical operation recently. The curative resection rate has improved from 65.1 to 79.1 percent for colon cancer and from 71.4 to 80.4 percent for rectal cancer between the 1974 and 1979 and the 1991 and 1994 periods, and operative mortality of those has decreased from 1.8 and 2 percent to 0.5 and 0.5 percent, respectively. There was a trend toward a decrease in locally advanced cancer in terms of cancer invasion into the bowel wall. Stage IV colon cancer also decreased from 22.9 to 16.6 percent with time. The five-year survival rate of each pTNM stage has gradually been improving and was especially evident for patients with Stages I, II, and III of rectal cancer. Overall five-year survival rates for colorectal cancer patients currently exceeds 60 percent. CONCLUSION: The overall incidence of colorectal cancer and the ratio of colon cancer to rectal cancer patients in Japan are increasing. Results of surgical treatment are satisfactory with respect to curative resection rate, operative mortality, and the five-year survival rate. Registry data of the Japanese Society for Cancer of the Colon and Rectum are useful for reporting the actual state of diagnosis, treatment, and end results of colorectal cancer in Japan.
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References
Koyama Y, Kotake K, eds. Japanese Society for Cancer of the Colon and Rectum: a multi-institutional registry of large bowel cancer in Japan. Vol. 1–12 (1–6 in Japanese and 7–12 in English). Tochigi: Registry Committee, 1985–1996.
Registry Committee. Japanese Society for Cancer of the Colon and Rectum: A general view of large bowel cancer in Japan. In: Watanabe S, Tominaga S, Kakizoe T, eds. Cancer treatment and survival: site-specific registries in Japan. Gann Monograph on Cancer Research. No. 43. Tokyo: Japan Scientific Societies Press, 1995:57–67.
Japanese Research Society for Cancer of the Colon and Rectum. General rules for clinical and pathological studies on cancer of the colon, rectum and anus. Jpn J Surg 1983;13:557–73.
Statistics and Information Department. Ministry of Health and Welfare. Vital statistics of Japan 1992. Tokyo: Kosei Tokei Kyokai, 1994.
Tominaga S, Aoki K, Kurihara M, eds. Cancer mortality and morbidity statistics: Japan and the world—1994. Gann Monograph on Cancer Research. No. 41. Tokyo: Japan Scientific Societies Press, 1994: 27, 62, 113–117, 131.
Koutsky LA, Holmes KK, Critchlow CW,et al. A cohort study of the risk of cervical intraepithelial neoplasm grade 2 or 3 in relation to papillomavirus infection. N Engl J Med 1992;327:1272–8.
Munoz N, Bosch FX, DE Sanjose S,et al. The causal link between human papillomavirus and invasive cervical cancer: a population-based case-control study in Colombia and Spain. Int J Cancer 1992;52:743–9.
Bosch FX, Munoz N, DE Sanjose S,et al. Risk factors for cervical cancer in Colombia and Spain. Int J Cancer 1992;52:750–8.
Henzel W, Berg JW, Segi M,et al. Large-bowel cancer in Hawaiian Japanese. J Natl Cancer Inst 1973;51:1765–79.
Tajima K, Tominaga S. Dietary habits and gastrointestinal cancers: a comparative case-control study in Nagoya, Japan. Jpn J Cancer Res 1985;76:705–16.
Kotake K, Koyama Y, Nasu J,et al. Relation of family history of cancer and environmental factors to the risk of colorectal cancer: a case-control study. Jpn J Clin Oncol 1995;25:195–202.
Steele GD Jr. The National Cancer Data Base Report on Colorectal Cancer. Cancer 1994;74:1979–89.
Jessup JM, McGinnis LS, Steele Jr GD,et al. The National Cancer Data Base Report on Colon Cancer. Cancer 1996;78:918–26.
Evans JT, Vana J, Aronoff BL,et al. Management and survival of carcinoma of the colon: results of a national survey by American College of Surgeons. Ann Surg 1978;188:716–20.
Allum WH, Slaney G, McConkey CC, Powell J. Cancer of the colon and rectum in the West Midlands, 1957–1981. Br J Surg 1994;81:1060–3.
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Supported in part by a Grant-in Aid for Cancer Research from the Ministry of Health and Welfare of Japan.
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Koyama, Y., Kotake, K. Overview of colorectal cancer in Japan. Dis Colon Rectum 40 (Suppl 10), S2–S9 (1997). https://doi.org/10.1007/BF02062013
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DOI: https://doi.org/10.1007/BF02062013