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Ultrasound-guided core needle biopsy in the diagnosis of neuroblastic tumors in children: a retrospective study on 83 cases

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Abstract

Aim

Ultrasound-guided biopsy technique with the large-core needle has widely been applied in the diagnosis of adult abdominopelvic cavity, thyroid, and neck tumors. There are few reports on ultrasound-guided biopsy using large-core needle in pediatric abdominopelvic cavity tumors. This study was to evaluate the ultrasound features and the diagnostic value of ultrasound-guided core needle biopsy for pediatric neuroblastic tumors.

Methods

The pediatric patients with neuroblastic tumor that underwent ultrasound examination and ultrasound-guided core needle biopsy from January 2009 to November 2015 were reviewed. A minimum of two cores in each case was obtained. The biopsy results were confirmed by subsequent surgical histopathology. The ultrasound features and the diagnostic accuracy of ultrasound-guided core needle biopsy were evaluated.

Results

Eighty-three patients were enrolled into the study. Conventional ultrasound examination showed irregular hypoechoic or mixed echo masses and calcification and liquefied necrosis. The diagnostic accuracy of ultrasound-guided core needle biopsy was 96.4% (80/83). Three cases were misdiagnosed because of inadequate tissue sample. No serious complication, infection, or needle track seeding occurred.

Conclusions

Ultrasound-guided core needle biopsy seems to be an accurate, minimally invasive, and safe diagnostic method of pediatric neuroblastic tumor.

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Abbreviations

GN:

Ganglioneuroma

GNB:

Ganglioneuroblastoma

NB:

Neuroblastoma

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Author notes

    Authors and Affiliations

    1. Department of Diagnostic and Therapeutic Ultrasonography, Tianjin Medical University Cancer Institute and Hospital, Huan-Hu-Xi Road, Ti-Yuan-Bei, He Xi District, Tianjin, 300060, China

      Lihui Zhao, Jie Mu, Ping Du, Hailing Wang, Yiran Mao, Yong Xu & Xiaojie Xin

    2. Department of Pathology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China

      Fenglin Zang

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    1. Lihui Zhao
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    2. Jie Mu
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    3. Ping Du
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    4. Hailing Wang
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    5. Yiran Mao
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    6. Yong Xu
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    7. Xiaojie Xin
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    8. Fenglin Zang
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    Corresponding author

    Correspondence to Hailing Wang.

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    The authors declare that they have no conflict of interest.

    Additional information

    Lihui Zhao and Jie Mu share the first authorship and contributed equally to this study.

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    Zhao, L., Mu, J., Du, P. et al. Ultrasound-guided core needle biopsy in the diagnosis of neuroblastic tumors in children: a retrospective study on 83 cases. Pediatr Surg Int 33, 347–353 (2017). https://doi.org/10.1007/s00383-016-4037-4

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    • DOI: https://doi.org/10.1007/s00383-016-4037-4

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