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Expression and prognostic value of the Ki-67 in Wilms’ tumor: experience with 48 cases

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Abstract

Purpose

Ki-67, tumor proliferation marker, is an important prognostic factor in a variety of cancers. In the present study, we investigated the expression and the prognostic value of Ki-67 in nephroblastoma.

Methods

Ki-67 expressions were investigated by immunohistochemistry on paraffin-embedded material in 48 children operated on because of nephroblastoma. Patients were treated according to SIOP protocol. The mean follow-up period was 5.4 years. A proliferation index was obtained by immunohistochemistry using anti-Ki-67 anti-body.

Results

The mean Ki-67 proliferation index in the blastemal type was 12.3%, and in the epithelial type, 21.4%. In the anaplastic type, Ki-67 proliferation index was: in the blastemal component 20%, in the stromal 21%, and in the epithelial 31%. In the mixed tumor type, Ki-67 proliferation index was assessed as: in the blastemal component 10%, in the epithelial 33% and in the stromal 31.5%. Proliferation index for the epithelium was significantly higher than those found for the blastema (P = 0.001). A correlation between Ki-67 and tumor stage found proliferation index significantly higher in stages I and II (P = 0.002).

Conclusion

The results support the conclusion that Ki-67 is a relevant marker for assessing the proliferative activity and tumor cell dynamics of nephroblastoma, but it may not be a good clinical prognostic marker.

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Authors and Affiliations

  1. Department of Pediatric Surgery, University Hospital Split and Split University School of Medicine, Spinčićeva 1, 21 000, Split, Croatia

    Ivo Jurić, Zenon Pogorelić & Mihovil Biočić

  2. Department of Pathology, University Hospital Split and Split University School of Medicine, Spinčićeva 1, 21 000, Split, Croatia

    Ivana Kuzmić-Prusac

  3. Department of Pediatrics, Childrens’ Hospital Zagreb, Klaićeva 16, 10 000, Zagreb, Croatia

    Gordana Jakovljević & Jasminka Stepan

  4. Department of Pediatric Surgery, Childrens’ Hospital Zagreb, Klaićeva 16, 10 000, Zagreb, Croatia

    Božidar Župančić

  5. Department of Pediatrics, University Hospital Split and Split University School of Medicine, Spinčićeva 1, 21 000, Split, Croatia

    Srđana Čulić

  6. Department of Pathology, University Hospital Sestre Milosrdnice, Vinogradska 29, 10 000, Zagreb, Croatia

    Božo Krušlin

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  1. Ivo Jurić
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  2. Zenon Pogorelić
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Correspondence to Zenon Pogorelić.

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Jurić, I., Pogorelić, Z., Kuzmić-Prusac, I. et al. Expression and prognostic value of the Ki-67 in Wilms’ tumor: experience with 48 cases. Pediatr Surg Int 26, 487–493 (2010). https://doi.org/10.1007/s00383-010-2588-3

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