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The prognostic importance of serum IL-1β, IL-6, IL-8 and TNF-α levels compared to trauma scoring systems for early mortality in children with blunt trauma

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Abstract

The purpose of the present study was to determine whether a correlation exits between the main trauma scoring systems and the activation of inflammatory cells and mediators such as interleukin-(IL-) 1β, IL-6, IL-8 and tumor necrosis factor alpha (TNF-α) after trauma, and moreover to assess if any of these can be used to predict the outcome in patients under care at a trauma center. Forty-seven children (37 boys, 10 girls) presenting with blunt trauma, were evaluated by an analysis of the relationship between overall mortality and potential risk factors. Admission data, including serum IL-1β, IL-6, IL-8, TNF-α, pediatric trauma score (PTS), and injury severity score (ISS), were collected and analyzed. In descriptive statistics for independent variables, some prognostic factors such as IL-8 (P = 0.04), and ISS (P = 0.004) were significant in their relationship to mortality. In the univariate statistical analysis some other risk factors such as IL-8 (P = 0.004), >20 TNF-α (P = 0.04), and ISS (P = 0.007) were significant in their relationship to mortality. The relative risk of developing mortality was higher than two for each of the following risk factors: >10 ages, >25 IL-6, 10–20 TNF-α, >20 TNF-α, PTS ≤ 8, and ISS > 15. There was a positive correlation between IL-8 (r = 0.31, P = 0.33), ISS (r = 0.31, P = 0.0001), and mortality. There was also a correlation with ISS and IL-8 (r = 0.32, P = 0.02). ISS, and the serum IL-8 level are the most important determinants of clinical outcome in critically injured patients. A correlation exits between IL-8 and mortality and between ISS and IL-8.

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Authors and Affiliations

  1. Department of Pediatric Surgery, Medical School, Abant Izzet Baysal University, 14280, Bolu, Turkey

    Hayrettin Ozturk

  2. Department of General Surgery, Medical School, Dicle University, Diyarbakir, Turkey

    Yusuf Yagmur

  3. Department of Pediatric Surgery, Izzet Baysal Obstetric and Children Hospital, Bolu, Turkey

    Hulya Ozturk

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  1. Hayrettin Ozturk
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  2. Yusuf Yagmur
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  3. Hulya Ozturk
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Correspondence to Hayrettin Ozturk.

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Ozturk, H., Yagmur, Y. & Ozturk, H. The prognostic importance of serum IL-1β, IL-6, IL-8 and TNF-α levels compared to trauma scoring systems for early mortality in children with blunt trauma. Pediatr Surg Int 24, 235–239 (2008). https://doi.org/10.1007/s00383-007-2083-7

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