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Metachronous gliomas following cranial irradiation for mixed germ cell tumors

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Abstract

Introduction

Cranial irradiation has been widely used as a therapeutic tool for treating various lesions, particularly neoplastic diseases. Even though radiation therapy is usually well-tolerated, it occasionally causes clinically significant long-term toxicity such as radiation necrosis and irradiation-related arteriopathy with stroke.

Discussion and case report

The development of neoplasms following therapeutic cranial irradiation is also rare, but may cause serious and potentially fatal complications. Various radiation-induced tumors, including meningioma, glioma, and sarcoma have been reported (Child Nerv Syst 24:793–805, 12). However, metachronous intracranial double tumors induced by radiation therapy are extremely rare. In here, we report a case of metachronous different gliomas including astrocytoma and glioblastoma following irradiation therapy after 41 and 46 months, respectively.

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Authors and Affiliations

  1. Department of Radiology of St. Luke’s International Hospital, Tokyo, Japan

    Akari Makidono, Nobuo Kobayashi & Yukihisa Saida

  2. Department of Pediatrics of St. Luke’s International Hospital, Tokyo, Japan

    Atsushi Manabe

  3. Department of Radiation Oncology of St. Luke’s International Hospital, Tokyo, Japan

    Jiro Kawamori

  4. Department of Pathology of St. Luke’s International Hospital, Tokyo, Japan

    Koyu Suzuki

Authors
  1. Akari Makidono
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  2. Nobuo Kobayashi
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  3. Yukihisa Saida
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  4. Atsushi Manabe
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  5. Jiro Kawamori
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  6. Koyu Suzuki
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Corresponding author

Correspondence to Akari Makidono.

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Makidono, A., Kobayashi, N., Saida, Y. et al. Metachronous gliomas following cranial irradiation for mixed germ cell tumors. Childs Nerv Syst 25, 713–718 (2009). https://doi.org/10.1007/s00381-009-0829-3

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  • DOI: https://doi.org/10.1007/s00381-009-0829-3

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