Radiation-associated xanthomatous meningioma in a child

Abstract 

Radiation-associated meningioma in a child is rare. We report a case of xanthomatous meningioma, a rare subtype even in the adult population, which occurred in a 10-year-old boy who had undergone irradiation therapy for ependymoma at the age of 2 years. Histological examination of the tumor revealed a mixture of meningothelial cells and abundant foamy xanthomatous cells, with no apparent atypical cellular features. Xanthomatous meningioma associated with therapeutic high-dose irradiation in a child has not yet been documented. Immunohistochemical studies and the clinical course are evaluated with a review of the literature.