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Current concepts in the molecular genetics of pediatric brain tumors: implications for emerging therapies

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Abstract

Background

The revolution in molecular biology that has taken place over the past 2 decades has provided researchers with new and powerful tools for detailed study of the molecular mechanisms giving rise to the spectrum of pediatric brain tumors. Application of these tools has greatly advanced our understanding of the molecular pathogenesis of these lesions.

Review

After familiarizing readers with some promising new techniques in the field of oncogenomics, this review will present the current state of knowledge as it pertains to the molecular biology of pediatric brain neoplasms. Along the way, we hope to highlight specific instances where the detailed mechanistic knowledge acquired thus far may be exploited for therapeutic advantage.

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Acknowledgements

This work was supported by grants from the National Cancer Institute of Canada, the Pediatric Brain Tumor Foundation, the Wiley Fund, and the Laurie Berman Fund for Brain Tumor Research.

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  1. Division of Neurosurgery, The Hospital for Sick Children, The University of Toronto, Toronto, Ontario, Canada

    Mandeep S. Tamber, Krishan Bansal, Muh-Lii Liang, Todd G. Mainprize, Bodour Salhia, Paul Northcott, Michael Taylor & James T. Rutka

  2. Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, The University of Toronto, Toronto, Ontario, Canada

    Mandeep S. Tamber, Krishan Bansal, Muh-Lii Liang, Todd G. Mainprize, Bodour Salhia, Paul Northcott, Michael Taylor & James T. Rutka

  3. The Division of Neurosurgery, Suite 1504, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, 518, Canada

    James T. Rutka

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Tamber, M.S., Bansal, K., Liang, ML. et al. Current concepts in the molecular genetics of pediatric brain tumors: implications for emerging therapies. Childs Nerv Syst 22, 1379–1394 (2006). https://doi.org/10.1007/s00381-006-0187-3

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