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The potential of cardiac rehabilitation as a method of suppressing abdominal aortic aneurysm expansion: a pilot study

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A Correction to this article was published on 11 July 2019

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Abstract

This study is a prospective evaluation of the effectiveness of cardiac rehabilitation (CR) in terms of clinical outcomes for small abdominal aortic aneurysms (AAA) that were previously reported in a retrospective cohort study. We conducted a prospective non-randomized trial on patients with small AAA (N = 40; mean age 75.0 ± 6.6 years). Patients were enrolled into one of two groups, rehabilitation (CR) or non-rehabilitation (non-CR) group. Only CR group participated in a supervised-CR program including bicycle ergometer for 150 days. The AAA expansion rate and the risk of AAA repair were compared between two groups. We also researched the relationship between AAA expansion rate and body composition, blood IL-6 and TGFβ1 levels. The CR (N = 15) and non-CR groups (N = 25) were comparable in terms their baseline data. The CR group had a significantly smaller change in the maximal AAA size (− 1.3 ± 2.4 mm/years) compared to the non-CR group (2.0 ± 3.6 mm/years) (p < 0.01). The IL-6, and TGFβ1 levels were unrelated to the changes in AAA size. There was mild positive correlation between the change in systolic blood pressure from rest to exercise and the AAA expansion rate (p = 0.06). The risk of AAA repair after 12 months was lower in the CR group compared to the non-CR group (0% vs. 28%, respectively). CR in patients with small AAA significantly suppressed AAA expansion and resulted in a lowered risk of AAA repair.

Clinical trial Trial name: The study of the profitability and protective effect of cardiac rehabilitation on abdominal aortic aneurysm. Number: UMIN000028237. UTL: https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R0000323.

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Change history

  • 11 July 2019

    In the original publication of the article, under the result section.

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Acknowledgements

This study was supported by a Grants-in-aid for Scientific Research from Ministry of Education, Culture, Sports, Science and Technology in Japan. AN and EA contributed to the conception or design of the work. AN contributed to the acquisition. KH, NT, YK, MT, and TF contributed to interpretation. YH, KH, and IK contributed to analysis of data for the work. AN drafted the manuscript. EA and HM critically revised the manuscript. All gave final approval and agreed to be accountable for all aspects of work ensuring integrity and accuracy. No funding was provided specifically for conducting the analysis, drafting the manuscript, or submitting this paper for publication.

Funding

This study was supported by a Grants-in-aid for Scientific Research from Ministry of Education, Culture, Sports, Science and Technology in Japan (Grant no. 15K16351).

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Authors and Affiliations

  1. Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan

    Atsuko Nakayama, Eisuke Amiya, Hiroyuki Morita, Kanako Hyodo, Naoko Takayama, Yuto Konishi, Masanobu Taya, Yumiko Hosoya & Issei Komuro

  2. Division of Vascular Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

    Katsuyuki Hoshina

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  1. Atsuko Nakayama
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Correspondence to Atsuko Nakayama.

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Nakayama, A., Amiya, E., Morita, H. et al. The potential of cardiac rehabilitation as a method of suppressing abdominal aortic aneurysm expansion: a pilot study. Heart Vessels 34, 2031–2039 (2019). https://doi.org/10.1007/s00380-019-01441-x

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