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Effect of rhBNP on renal function in STEMI-HF patients with mild renal insufficiency undergoing primary PCI

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Abstract

This study aims to investigate the effect of recombinant human brain natriuretic peptide (rhBNP) on renal function and contrast-induced nephropathy (CIN) incidence in ST-segment elevation myocardial infarction and heart failure (STEMI-HF) patients with mild renal insufficiency undergoing primary percutaneous coronary intervention (PCI). A total of 116 participants were randomized into rhBNP (rhBNP, n = 57) and nitroglycerin group (NIT, n = 59), receiving intravenous rhBNP or nitroglycerin from admission to 72 h after PCI. Renal function was assessed by serum creatinine (SCr), estimated glomerular filtration rate (eGFR), Cystatin-C (Cys-C) and β2-microglobulin before and after primary PCI, and calculated the incidence of CIN within 72 h after PCI. There were no significant differences in SCr, eGFR and β2-microglobulin between the two groups (P > 0.05, respectively). Compared with the NIT group, the total urinary volume within 72 h was higher while the level of Cys-C at 24 and 72 h after PCI was lower in the rhBNP group. rhBNP was associated with a decline in the incidence of CIN (12.28 vs. 28.81 %, P < 0.05). No differences were detected in mortality and re-hospitalization in 3 months between the two groups. The incidence of renal injury was not different between rhBNP and nitroglycerin in STEMI-HF patients with mild renal insufficiency. However, infusion of rhBNP was associated with a decline in incidence of CIN.

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Authors and Affiliations

  1. Department of Cardiology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China

    Kun Xing, Xianghua Fu, Yanbo Wang, Wei Li, Xinshun Gu, Guozhen Hao, Qing Miao, Shiqiang Li, Yunfa Jiang, Weize Fan & Wei Geng

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  1. Kun Xing
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  2. Xianghua Fu
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  3. Yanbo Wang
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  4. Wei Li
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Correspondence to Xianghua Fu.

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Xing, K., Fu, X., Wang, Y. et al. Effect of rhBNP on renal function in STEMI-HF patients with mild renal insufficiency undergoing primary PCI. Heart Vessels 31, 490–498 (2016). https://doi.org/10.1007/s00380-015-0642-8

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  • DOI: https://doi.org/10.1007/s00380-015-0642-8

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