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Cyclic AMP-dependent memory mutants are defective in the food choice behavior of Drosophila

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Abstract

Acute choice behavior in ingesting two different concentrations of sucrose in Drosophila is presumed to include learning and memory. Effects on this behavior were examined for four mutations that block associative learning (dunce, rutabaga, amnesiac, and radish). Three of these mutations cause cyclic AMP signaling defects and significantly reduced taste discrimination. The exception was radish, which affects neither. Electrophysiological recordings confirmed that the sensitivity of taste receptors is almost indistinguishable in all flies, whether wild type or mutant. These results suggest that food choice behavior in Drosophila involves central nervous learning and memory operating via cyclic AMP signaling pathways.

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Abbreviations

cAMP:

Cyclic adenosine monophosphate

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Authors and Affiliations

  1. Department of Developmental Biology and Neuroscience, Graduate School of Life Sciences, Tohoku University, Sendai, 980-8578, Japan

    Katsunori Motosaka, Masayuki Koganezawa, Satoko Narikawa, Akira Furuyama & Ichiro Shimada

  2. Laboratory of Information Biology, Graduate School of Information Science, Tohoku University, Sendai, 980-8578, Japan

    Kenji Shinozaki & Kunio Isono

Authors
  1. Katsunori Motosaka
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  2. Masayuki Koganezawa
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  3. Satoko Narikawa
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  4. Akira Furuyama
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  5. Kenji Shinozaki
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  6. Kunio Isono
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  7. Ichiro Shimada
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Correspondence to Ichiro Shimada.

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Motosaka, K., Koganezawa, M., Narikawa, S. et al. Cyclic AMP-dependent memory mutants are defective in the food choice behavior of Drosophila . J Comp Physiol A 193, 279–283 (2007). https://doi.org/10.1007/s00359-006-0200-z

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  • DOI: https://doi.org/10.1007/s00359-006-0200-z

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