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Comparison of cell cycle progression score with two immunohistochemical markers (PTEN and Ki-67) for predicting outcome in prostate cancer after radical prostatectomy

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Abstract

Purpose

Previous studies of the cell cycle progression (CCP) score in surgical specimens of prostate cancer (PCa) in patients treated by radical prostatectomy (RP) demonstrated significant association with time to biochemical recurrence (BCR). In this study, we compared the ability of the CCP score and the expression of PTEN or Ki-67 to predict BCR in a cohort of patients treated by RP. Finally, we constructed the best predictive model for BCR, incorporating biomarkers and relevant clinical variables.

Materials and methods

The study population consisted of 652 PCa patients enrolled in a retrospective cohort and who had RP surgery in French urological centers from 2000 to 2007.

Results

Among the 652 patients with CCP scores and complete clinical data, BCR events occurred in 41%, and the median time from surgery to the last follow-up among BCR-free patients was 72 months. In univariate Cox analysis, the continuous CCP score and positive Ki-67 predicted recurrence with a HR of 1.44 (95% CI 1.17–1.75; p = 5.3 × 10−4) and 1.89 (95% CI 1.38–2.57; p = 1.6 × 10−4), respectively. In contrast, PTEN expression was not associated with BCR risk. Of the three biomarkers, only the CCP score remained significantly associated in a multivariable Cox model (p = 0.026). The best model incorporated CAPRA-S and CCP scores as predictors, with HRs of 1.32 and 1.24, respectively.

Conclusion

The CCP score was superior to the two IHC markers (PTEN and Ki-67) for predicting outcome in PCa after RP.

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Authors and Affiliations

  1. GRC No 5 ONCOTYPE-URO, Institut Universitaire de Cancérologie, Sorbonne Université, 75020, Paris, France

    Priscilla Léon, Geraldine Cancel-Tassin, Sara Drouin, Marie Audouin, Eva Comperat, Morgan Rouprêt & Olivier Cussenot

  2. Academic Department of Urology, CHU Reims, 51000, Reims, France

    Priscilla Léon

  3. CeRePP, 75020, Paris, France

    Geraldine Cancel-Tassin, Eva Comperat, Morgan Rouprêt, Gaelle Fromond-Hankard & Olivier Cussenot

  4. Academic Department of Urology, Hopital Pitie-Salpetriere, AP-HP, Sorbonne Université, 75013, Paris, France

    Sara Drouin, Christophe Vaessens & Morgan Rouprêt

  5. Academic Department of Urology, Hopital Tenon, AP-HP, Sorbonne Université, 75020, Paris, France

    Marie Audouin & Olivier Cussenot

  6. Academic Department of Pathology, Hopital Pitie-Salpetriere, AP-HP, Sorbonne Université, 75013, Paris, France

    Justine Varinot

  7. Academic Department of Pathology, Hopital Tenon, AP-HP, Sorbonne Université, 75020, Paris, France

    Eva Comperat

  8. Department of Urology, Institut Mutualiste Montsouris, Université René Descartes, 42 Boulevard Jourdan, 75674, Paris, France

    Xavier Cathelineau, François Rozet & Steven Stone

  9. Myriad Genetics, Inc., Salt Lake City, UT, USA

    Julia Reid, Zaina Sangale & Patrick Korman

  10. Academic Department of Pathology, CHU Tours, 37000, Tours, France

    Gaelle Fromond-Hankard

Authors
  1. Priscilla Léon
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  2. Geraldine Cancel-Tassin
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  3. Sara Drouin
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  4. Marie Audouin
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  5. Justine Varinot
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  6. Eva Comperat
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  7. Xavier Cathelineau
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  8. François Rozet
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  9. Christophe Vaessens
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  10. Steven Stone
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  11. Julia Reid
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  12. Zaina Sangale
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  13. Patrick Korman
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  14. Morgan Rouprêt
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  15. Gaelle Fromond-Hankard
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  16. Olivier Cussenot
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Contributions

PL: Manuscript Writing, data collection, data analysis, GC-T: Manuscript Writing, data collection, data analysis, SD: data collection, MA: data collection, JV: data collection, EC: data collection, XC: data collection, FR: data collection, CV: data collection, SS: data collection, JR: data analysis, ZS: data analysis, PK: Manuscript Writing, data analysis, MR: data collection, GF-H: data collection, OC: Manuscript Writing, Project development, data collection, data analysis.

Corresponding author

Correspondence to Priscilla Léon.

Ethics declarations

Conflict of interest

Study was conducted with financial support from Myriad Genetics SAS. O Cussenot is a consultant by Myriad Genetics SAS. J Reid, Z Sangale, and P Korman are employed by Myriad Genetics SAS. The other authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the Helsinki Declaration and its later amendments or comparable ethical standards. This article does not contain any studies with animals performed by any of the authors.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Léon, P., Cancel-Tassin, G., Drouin, S. et al. Comparison of cell cycle progression score with two immunohistochemical markers (PTEN and Ki-67) for predicting outcome in prostate cancer after radical prostatectomy. World J Urol 36, 1495–1500 (2018). https://doi.org/10.1007/s00345-018-2290-y

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  • DOI: https://doi.org/10.1007/s00345-018-2290-y

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