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Role of focal salvage ablative therapy in localised radiorecurrent prostate cancer

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Abstract

Up to one-third of men can fail radical external beam radiotherapy for primary prostate cancer. Most of these men have expectant management with delayed hormones. However, around half of these men have localised recurrence. Challenges remain in identifying such men accurately, in order to enable them to undergo local salvage therapy which is potentially curative. Currently, this includes radical prostatectomy, brachytherapy and ablative whole-gland therapies, such as cryotherapy and high intensity focused ultrasound, all of which can carry significant morbidity. New approaches may involve targeting the area of recurrence alone—focal salvage therapy—in order to reduce tissue damage and thus reduce morbidity. This requires accurate localisation of intraprostatic recurrent disease and precision targeted ablation.

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Acknowledgments

M. Emberton and H.U. Ahmed would like to acknowledge funding from the Medical Research Council (UK), the Pelican Cancer Foundation charity, Prostate Cancer UK, St. Peters Trust charity, Prostate Cancer Research Centre the Wellcome Trust, National Institute of Health Research-Health Technology Assessment programme and the US National Institute of Health-National Cancer Institute. M. Emberton receives funding in part from the UK National Institute of Health Research UCLH/UCL Comprehensive Biomedical Research Centre. A. Kanthabalan receives funding from the NCI-NIH.

Conflict of interest

M. Emberton and H.U. Ahmed receive funding from USHIFU, GSK and Advanced Medical Diagnostics for clinical trials. M. Emberton is a paid consultant to Steba Biotech and USHIFU. HU Ahmed has previously received consultancy payments from Oncura/GE Healthcare and Steba Biotech. M Emberton has previously received consultancy payments from Oncura/GE Healthcare. None of the other authors have any conflicts of interest.

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Authors and Affiliations

  1. Division of Surgery and Interventional Science, UCL, London, UK

    A. Kanthabalan, M. Emberton & H. U. Ahmed

  2. Department of Urology, UCLH NHS Foundation Trust, 250 Euston Road, London, NW1 2PG, UK

    A. Kanthabalan, M. Arya, M. Emberton & H. U. Ahmed

  3. Barts Cancer Institute, Queen Mary, University of London, London, UK

    M. Arya

  4. Division of Medicine, Centre for Medical Imaging, UCL, London, UK

    S. Punwani

  5. Department of Radiology, UCLH NHS Foundation Trust, London, UK

    S. Punwani

  6. Department of Histopathology, UCLH NHS Foundation Trust, London, UK

    A. Freeman

  7. Department of Nuclear Medicine, UCLH NHS Foundation Trust, London, UK

    A. Haroon & J. Bomanji

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  1. A. Kanthabalan
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  2. M. Arya
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Correspondence to A. Kanthabalan.

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Kanthabalan, A., Arya, M., Punwani, S. et al. Role of focal salvage ablative therapy in localised radiorecurrent prostate cancer. World J Urol 31, 1361–1368 (2013). https://doi.org/10.1007/s00345-013-1100-9

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  • DOI: https://doi.org/10.1007/s00345-013-1100-9

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