Skip to main content
SpringerLink
Log in

The protective effect of royal jelly against cisplatin-induced renal oxidative stress in rats

  • Original Article
  • Published:
World Journal of Urology Aims and scope Submit manuscript

Abstract

Background

The aim of this study was to investigate the effects of royal jelly on cisplatin-induced nephrotoxicity and oxidative stress in rats.

Methods

Adult male Wistar albino rats were randomly divided into eight groups: the control, cisplatin, royal jelly, and royal jelly plus cisplatin groups. Biochemical and histopathological methods were utilized for evaluation of the nephrotoxicity. Blood was collected and analyzed for blood urea nitrogen (BUN), alanine aminotransferase, aspartate aminotransferase, triglyceride, total cholesterol, uric acid, total bilirubin, and total protein levels. The kidney samples were stored for the measurement of malondialdehyde (MDA), glutathione peroxidase (GSHPx), superoxide dismutase (SOD), and catalase (CAT) activities and processed for histopathological examinations.

Results

Administration of cisplatin to rats induced a marked renal failure, characterized with a significant increase in serum BUN and uric acid concentrations, and they had higher kidney MDA and lower GSH-Px, SOD, and CAT activities. In the groups that were administered RJ in association with CP, improvement was observed in some oxidative stress parameters and certain other biochemical parameters, pre-treatment with RJ being more effective.

Conclusions

The CP-induced changes in histopathologic findings of kidneys were partially reversed by treatment with royal jelly. The results provide further insight into the mechanisms of CP-induced nephrotoxicity and confirm the antioxidant potential of royal jelly.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

References

  1. Sleijfer DT, Meijer S, Mulder RNH (1985) Cisplatin: a review of clinical applications and renal toxicity. Pharm Weekbl Sci 7:227–237

    Google Scholar 

  2. Kim YK, Jung JS, Lee SH, Kim YW (1997) Effects of antioxidants and Ca+2 in cisplatin-induced cell injury in rabbit renal cortical slices. Toxicol Appl Phamacol 146:261–269

    Article  CAS  Google Scholar 

  3. Badary OA, Abdel-Maksoud S, Ahmed WA, Owieda GH (2005) Naringenin attenuates cisplatin nephrotoxicity in rats. Life Sci 76:2125–2135

    Article  CAS  PubMed  Google Scholar 

  4. Lee RH, Song JM, Park MY, Kang SK, Kim YK, Jung JS (2001) Cisplatin-induced apoptosis by translocation of endogenous Bax in mouse collecting duct cells. Biochem Pharmacol 62:1013–1023

    Article  CAS  PubMed  Google Scholar 

  5. Offerman JJC, Meijer S, Sleijfer DT, Mulder NH, Donker AJM, Koops HS, van der Hem GK (1984) Acute effects of cis-diamminedichloroplatinum (CDDP) on renal function. Cancer Chemother Pharmacol 12:36–38

    Article  CAS  PubMed  Google Scholar 

  6. Li Q, Bowmer CJ, Yates MS (1994) Effects of arginine on cisplatin induced acute renal failure in the rat. Biochem Pharmacol 47:2298–2301

    Article  CAS  PubMed  Google Scholar 

  7. Jamnik P, Goranovic D, Raspor P (2007) Antioxidative action of royal jelly in the yeast cell. Exp Gerontol 42:594–600

    Article  CAS  PubMed  Google Scholar 

  8. El-Nekeety AA, El-Kholy W, Abbas NF, Ebaid A, Amra HA, Abdel-Wahhab AA (2007) Efficacy of royal jelly against the oxidative stress of fumonisin in rats. Toxicon 50:256–269

    Article  CAS  PubMed  Google Scholar 

  9. Karaali A, Meydanoglu F, Eke D (1988) Studies on composition, freeze-drying and storage of Turkish royal jelly. J Apic Res 27:182–185

    Google Scholar 

  10. Shinoda M, Nakajin S, OikawaT SatoK, Kamogawa A, Akiyama Y (1978) Biochemical studies on vasodilative factor in royal jelly. Yakugaku Zasshi 98:139–145

    CAS  PubMed  Google Scholar 

  11. Tamura T, Fujii A, Kumoyama N (1987) Antitumor effect of royal jelly. Folia Pharmacol Jpn 89:73–80

    Article  CAS  Google Scholar 

  12. Nakajin S, Okiyama K, Yamashita S, Akiyama Y, Shinoda M (1982) Effect of royal jelly on experimental hypercholesterolemia in rabbits. Yakugaku Zasshi 36:65–69

    Google Scholar 

  13. Sver L, Orsolic N, Tadic Z, Njari B, Valpotic I (1996) A royal jelly as a new potential immunomodulator in rats and mice. Comp Immunol Microbial Infect Dis 19:31–38

    Article  CAS  Google Scholar 

  14. Kanbur M, Eraslan G, Beyaz L, Silici S, Liman BC, Altınordulu S, Atasever A (2009) The effects of royal jelly on liver damage induced by paracetamol in mice. Exp Toxicol Path 61(2):123–132

    Article  CAS  Google Scholar 

  15. Ozcan S, Senyuva HZ (2006) Improved and simplified liquid chromatography/atmospheric pressure chemical ionization mass spectrometry method for the analysis of underivatized free amino acids in various foods. J Chromatogr A 1135:179–185

    Article  PubMed  Google Scholar 

  16. Ohkawa H, Ohishi N, Yagi K (1978) Reaction of linoleic acid hydroperoxide with thiobarbituric acid. J Lipid Res 19:1053–1057

    CAS  PubMed  Google Scholar 

  17. Sun Y, Oberley LW, Li Y (1988) Simple method for clinical assay of superoxide dismutase. Clin Chem 34:497–500

    CAS  PubMed  Google Scholar 

  18. Luck H (1965) Catalase. In: Bergmeyer H (ed) Methods of enzymatic analysis. Academic Press, New York, pp 885–894

    Google Scholar 

  19. Paglia DE, Valentine WN (1967) Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med 70:158–169

    CAS  PubMed  Google Scholar 

  20. Uzbekova D, Chugunova L, Makarova V, Ryabkov A, Mirgorodskaya L (1998) Efficacy of royal jelly and lactulose on thyroxin-induced liver damage in rats. J Hepatol 28(1):157

    Article  Google Scholar 

  21. Van Vleet TR, Schnellmann RG (2003) Toxic nephropathy: environmental chemicals. Semin Nephrol 23:500–508

    Article  PubMed  Google Scholar 

  22. Ajith TA, Usha S, Nivitha V (2007) Ascorbic acid and α-tocopherol protect anticancer drug cisplatin induced nephrotoxicity in mice: a comparative study. Clin Chim Acta 375:82–86

    Article  CAS  PubMed  Google Scholar 

  23. Yao X, Panichpisal K, Kurtzman N, Nugent K (2007) Cisplatin nephrotoxicity. Am J Med Sci 334(2):115–124

    Article  PubMed  Google Scholar 

  24. Kawai Y, Nakao T, Kunimura N, Kohda Y, Gemba M (2006) Relationship of intracellular calcium and oxygen radicals to cisplatin-related renal cell injury. J Pharmacol Sci 100:65–72

    Article  CAS  PubMed  Google Scholar 

  25. Liu X, Li J, Li Q, Ai Y, Zhang L (2008) Protective effects of ligustrazine on cisplatin-induced oxidative stress, apoptosis and nephrotoxicity in rats. Environ Toxicol Phar 26:49–55

    Article  CAS  Google Scholar 

  26. Seminotti B, Leipnitz G, Amaral AU, Fernandes CG, da Silva Lde B, Tonin AM, Vargas CR, Wajner M (2008) Lysine induces lipid and protein damage and decreases reduced glutathione concentrations in brain of young rats. Int J Dev Neurosci 26(7):693–698

    Article  CAS  PubMed  Google Scholar 

  27. Delwing D, Delwing D, Chiarani F, Kurek AG, Wyse ATS (2007) Proline reduces brain cytochrome c oxidase: prevention by antioxidants. Int J Dev Neurosci 25(1):17–22

    Article  CAS  PubMed  Google Scholar 

  28. El-Missiry MA, Fayed TA, El-Sawy MR, El-Sayed AA (2007) Ameliorative effect of melatonin against gamma-irradiation-induced oxidative stress and tissue injury. Ecotox Environ Safe 66(2):278–286

    Article  CAS  Google Scholar 

  29. Parodi PW (2007) A role for milk proteins and their peptides in cancer prevention. Curr Pharm Des 13:813–828

    Article  CAS  PubMed  Google Scholar 

  30. Zimmermann A (2002) Liver regeneration: the emergence of new pathways. Med Sci Monit 8(3):RA53–RA63

    PubMed  Google Scholar 

Download references

Conflict of interest statement

There is no conflict of interest.

Author information

Authors and Affiliations

  1. S. Cikrikcioglu Vocational College, Department of Animal Science, University of Erciyes, Kayseri, 38039, Turkey

    Sibel Silici

  2. Faculty of Medicine, Department of Urology, University of Erciyes, Kayseri, 38039, Turkey

    Oguz Ekmekcioglu

  3. Faculty of Veterinary Medicine, Department of Pharmacology and Toxicology, University of Erciyes, Kayseri, 38039, Turkey

    Murat Kanbur

  4. Faculty of Medicine, Department of Pathology, University of Erciyes, Kayseri, 38039, Turkey

    Kemal Deniz

Authors
  1. Sibel Silici
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Oguz Ekmekcioglu
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Murat Kanbur
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Kemal Deniz
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Sibel Silici.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Silici, S., Ekmekcioglu, O., Kanbur, M. et al. The protective effect of royal jelly against cisplatin-induced renal oxidative stress in rats. World J Urol 29, 127–132 (2011). https://doi.org/10.1007/s00345-010-0543-5

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00345-010-0543-5

Keywords

Search

Navigation