Skip to main content
SpringerLink
Log in

Acute effects of cis-diamminedichloroplatinum (CDDP) on renal function

  • Original Articles
  • Nephrotoxicity, Cis-Platinum
  • Published:
Cancer Chemotherapy and Pharmacology Aims and scope Submit manuscript

Summary

Ten previously untreated patients with metastatic non-seminomatous testicular carcinoma received cis-diamminechloroplatinum (CDDP). Renal function studies were performed before and following the first CDDP infusion. A decrease in effective renal plasma flow (ERPF) and an increase in filtration fraction (FF) was found in all patients. These findings suggest primary changes in renal hemodynamics during CDDP infusion.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Baehler RW, Kotchen TA, Burke JA, Galla JH, Bhathena D (1977) Considerations of the pathophysiology of mercuric chloride induced acute renal failure. J Lab Clin Med 90: 330

    Google Scholar 

  2. Donker AJM, van der Hem GK, Sluiter WJ, Beekhuis H (1977) A radioisotope method for simultaneous determination of the glomerular filtration rate and the effective renal plasma flow. Neth J Med 20: 97

    Google Scholar 

  3. Edwards GS, Lane M, Smith FE (1979) Long-term treatment with cis-dichlorodiammineplatinum(II)-vinblastine-bleomycin; possible association with severe coronary artery disease. Cancer Treat Rep 63: 551

    Google Scholar 

  4. Einhorn LH, Donohue J (1977) cis-Diamminodichloroplatinum, vinblastine, and bleomycin combination chemotherapy in disseminated testicular cancer. Ann Intern Med 87: 293

    Google Scholar 

  5. Flamenbaum W, McNeil SS, Kotchen TA, Saladino AJ (1972) Experimental acute renal failure induced by uranylnitrate in the dog. Circ Res 31: 682

    Google Scholar 

  6. Harrell RM, Sibley R, Vogelzang NJ (1982) Renal vascular lesions after chemotherapy with vinblastine, bleomycin, and cisplatin. Am J Med 73: 429

    Google Scholar 

  7. Kletzel M, Jaffe N (1981) Systemic hypertension: a complication of intra-arterial cis-diammine dichloroplatinum(II) infusion. Cancer 47: 245

    Google Scholar 

  8. Meijer S, Mulder NH, Sleijfer DTh, de Jong PE, Sluiter WJ, Schraffordt Koops H, van der Hem GK (1982) Nephrotoxicity of cis-diamminedichloride platinum (CDDP) during remission-induction and maintenance chemotherapy of testicular carcinoma. Cancer Chemother Pharmacol 8: 27

    Google Scholar 

  9. Meijer S, Sleijfer DTh, Mulder NH, Sluiter WJ, Marrink J, Schraffordt Koops H, Brouwers ThM, Oldhoff J, van der Hem GK, Mandema E (1983) Some effects of combination chemotherapy with cis-platinum on renal function in patients with non seminomatous testicular carcinoma. Cancer 51: 2035

    Google Scholar 

  10. Rozenczeig M, Von Hoff DD, Slavik M, Muggia FM (1977) cis-Diamminedichlorplatinum (II): A new anticancer drug. Ann Intern Med 86: 803

    Google Scholar 

  11. Stein HJ, Gottschall J, Osgood RW (1975) Pathophysiology of a nephrotoxic model of acute renal failure. Kidney Int 8: 27

    Google Scholar 

  12. Vogelzang NJ, Bosl GJ, Johnson K, Kennedy BJ (1981) Raynaud's phenomenon: a common toxicity after combination chemotherapy for testicular cancer. Ann Intern Med 95: 288

    Google Scholar 

  13. Williams CJ, Whitehouse JMA (1979) cis-Platinum, a new anticancer agent. Br Med J I: 1689

    Google Scholar 

  14. Wiltshaw E, Kroner T (1976) Phase II study of cis-dichlorodiammineplatinum (II) in advanced adenocarcinoma of the ovary. Cancer Treat Rep 60: 55

    Google Scholar 

  15. Winston J, Daye M, Safirstein R (1982) Determinants of diminished glomerular filtration rate (GFR) in cisplatin (Pt)-induced renal failure. 15th Meeting of Am Soc of Nephrol, Chicago, December 12–14, Abstract 117A, p 57

Download references

Author information

Authors and Affiliations

  1. Department of Internal Medicine, Division of Nephrology, University Hospital, Oostersingel 59, 9713 EZ, Groningen, The Netherlands

    Joop J. G. Offerman, Sijtze Meijer, Dirk Th. Sleijfer, Nanno H. Mulder, Ab J. M. Donker & Gjalt K. van der Hem

  2. Department of Internal Medicine, Division of Medical Oncology, University Hospital, Oostersingle 59, 9713 EZ, Groningen, The Netherlands

    Joop J. G. Offerman, Sijtze Meijer, Dirk Th. Sleijfer, Nanno H. Mulder, Ab J. M. Donker & Gjalt K. van der Hem

  3. Department of Surgical Oncology, University Hospital, Oostersingel 59, 9713 EZ, Groningen, The Netherlands

    Heimen Schraffordt Koops

Authors
  1. Joop J. G. Offerman
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Sijtze Meijer
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Dirk Th. Sleijfer
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Nanno H. Mulder
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Ab J. M. Donker
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Heimen Schraffordt Koops
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Gjalt K. van der Hem
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Offerman, J.J.G., Meijer, S., Sleijfer, D.T. et al. Acute effects of cis-diamminedichloroplatinum (CDDP) on renal function. Cancer Chemother. Pharmacol. 12, 36–38 (1984). https://doi.org/10.1007/BF00255906

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00255906

Keywords

Search

Navigation