Abstract
A new drug delivery system (DDS) consisting of electrospun nanofibers is proposed. Layered mats of hydrophobic polycaprolactone (PCL) and polyethylene oxide (PEO) nanofibers were prepared successfully in a layer-by-layer manner using an electrospinning process. The PEO mat and drug were co-electrospun as a drug reservoir. Drug release rate was controlled physically by the thickness of the electrospun nanofibrous PCL layer, and its release behavior was examined over time. Release tests showed that the release behavior and the amount of initial burst of the drug were critically dependent on the thickness of the nanofibrous PCL mat. The release of drug showed a linear relationship with the thickness of the porous electrospun PCL mat. In addition, to demonstrate the feasibility of this type of DDS, the release behavior of the antimicrobial peptide HPA3NT3 from the nanofiber system was examined. The release of the peptide was easily controlled by the PCL nanofiber thickness and the released peptide did not lose biological activity.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
J. Zeng, X. Xu, X. Chen, Q. Liang, X. Bian, L. Yang, X. Jing, J. Control. Release 92, 227 (2003)
D. Li, Y. Xia, Adv. Mater. 16, 1151 (2004)
Z.-M. Huang, Y.-Z. Zhang, M. Kotaki, S. Ramakrishna, Compos. Sci. Technol. 63, 2223 (2003)
Z. Ma, M. Kotaki, R. Inai, S. Ramakrishna, Tissue Eng. 11, 101 (2005)
K. Sawicka, P. Gouma, S. Simon, Sens. Actuators, B, Chem. 108, 585 (2005)
E. Luong-Van, L. Grøndahl, K.N. Chua, K.W. Leong, V. Nurcombe, S.M. Cool, Biomaterials 27, 2042 (2006)
E.R. Kenawy, G.L. Bowlin, G.E. Wnek, J. Control. Release 81, 57 (2002)
H. Jiang, Y. Hu, Y. Li, P. Zhao, K. Zhu, W. Chen, J. Control. Release 108, 237 (2005)
G.H. Kim, T. Min, S.-A. Park, W.D. Kim, Bioinspir. Biomim. 3, 016006 (2008)
S.-C. Park, M.-H. Kim, M.A. Hossain, S.Y. Shin, Y. Kim, J.D. Wade, Y. Park, K.-S. Hahm, BBA-Biomembranes 1778, 229 (2008)
G.H. Kim, H. Yoon, Appl. Phys. A 90, 389 (2008)
H. Lee, H. Yoon, G.H. Kim, Appl. Phys. A 97, 559 (2009)
P.D. Murray, Guide to Protein Purification Method in Enzymology, vol. 182 (Academic Press, New York, 1990)
J. Hindler, Adv. Exp. Med. Biol. 349, 67 (1994)
S.J. Eichhorn, W.W. Sampson, J. R. Soc. Interface 2, 309 (2005)
P.W. Gibson, H.L. Schreuder-Gibson, D. Rivin, AIChE J. 45, 190 (1999)
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Kim, G., Yoon, H. & Park, Y. Drug release from various thicknesses of layered mats consisting of electrospun polycaprolactone and polyethylene oxide micro/nanofibers. Appl. Phys. A 100, 1197–1204 (2010). https://doi.org/10.1007/s00339-010-5785-y
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00339-010-5785-y