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Thinking about RNA? MicroRNAs in the brain

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Abstract

MicroRNAs (miRNAs) are a recently discovered class of small RNA molecules implicated in a wide range of diverse gene regulatory mechanisms. Interestingly, numerous miRNAs are expressed in a spatially and temporally controlled manner in the nervous system. This suggests that gene regulation networks based on miRNA activities may be particularly relevant in neurons. Recent studies show the involvement of RNA-mediated gene silencing in neurogenesis, neural differentiation, synaptic plasticity, and neurologic and psychiatric diseases. This review focuses on the roles of miRNAs in the gene regulation of the nervous system.

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Acknowledgments

This work was partially funded by FIRB RBLA03FLJC-005 and FIRB RBIN04H5AS_002, PRIN prot. No. 2005055188-002 and TELETHON grant GGP05269 (to CC). This work was supported in part by ‘Fondazione Alazio Award 2007’ (to CB) (www.fondazionealazio.org, Via Torquato Tasso 22, 90144 Palermo). We thank Francesca Ruberti and Mauro Cozzolino for helpful discussions and comments on the manuscript.

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  1. European Brain Research Institute (EBRI), Fondazione EBRI, Rita Levi-Montalcini Via del Fosso di Fiorano, 64/65, 00143, Roma, Italy

    Christian Barbato, Corinna Giorgi, Caterina Catalanotto & Carlo Cogoni

  2. Dipartimento di Biotecnologie Cellulari ed Ematologia, Sezione di Genetica Molecolare, Università di Roma “La Sapienza”, Viale Regina Elena, 324, 00161, Roma, Italy

    Caterina Catalanotto & Carlo Cogoni

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  1. Christian Barbato
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Correspondence to Christian Barbato.

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Barbato, C., Giorgi, C., Catalanotto, C. et al. Thinking about RNA? MicroRNAs in the brain. Mamm Genome 19, 541–551 (2008). https://doi.org/10.1007/s00335-008-9129-6

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