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Genetic dissection of testicular weight in the mouse with the BXD recombinant inbred strains

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Abstract.

Testicular weights were studied in the mouse BXD recombinant inbred (RI) strains. These strains were derived from DBA/2J and C57BL/6J progenitors that differ significantly in their testicular weights (0.224 g ± 0.015 vs. 0.161 g ± 0.03, P < 0.0001). The heritability of testicular weights was calculated to be 0.53, and the minimum number of responsible effective factors was estimated to be 5.7. The total genome scanning of the BXD RI strains with over 1000 markers revealed a quantitative trait locus (QTL) on mouse Chromosome (Chr) 13 near the D13Mit3 marker (LOD score 6.9). This QTL region was designated Twq1 and associated with over 75% of genetic variability.

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Authors and Affiliations

  1. Institute of Physiology, Academy of Sciences of the Czech Republic, Videňská 1083, 14220 Prague 4, Czech Republic, , , , , , CS

    Václav Zídek, Alena Musilová, Jan Pintíř, Miroslava Šimáková & Michal Pravenec

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  1. Václav Zídek
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  2. Alena Musilová
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  3. Jan Pintíř
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  4. Miroslava Šimáková
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  5. Michal Pravenec
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Received: 23 January 1998 / Accepted: 16 March 1998

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Zídek, V., Musilová, A., Pintíř, J. et al. Genetic dissection of testicular weight in the mouse with the BXD recombinant inbred strains. 9, 503–505 (1998). https://doi.org/10.1007/s003359900808

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  • DOI: https://doi.org/10.1007/s003359900808

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