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Insights from human/mouse genome comparisons

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Abstract

Large-scale public genomic sequencing efforts have provided a wealth of vertebrate sequence data poised to provide insights into mammalian biology. These include deep genomic sequence coverage of human, mouse, rat, zebrafish, and two pufferfish (Fugu rubripes and Tetraodon nigroviridis) (Aparicio et al. 2002; Lander et al. 2001; Venter et al. 2001; Waterston et al. 2002). In addition, a high-priority has been placed on determining the genomic sequence of chimpanzee, dog, cow, frog, and chicken (Boguski 2002). While only recently available, whole genome sequence data have provided the unique opportunity to globally compare complete genome contents. Furthermore, the shared evolutionary ancestry of vertebrate species has allowed the development of comparative genomic approaches to identify ancient conserved sequences with functionality. Accordingly, this review focuses on the initial comparison of available mammalian genomes and describes various insights derived from such analysis.

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Acknowledgements

This work was supported in part by the NIH-NHLBI Programs for Genomic Application Grant HL66681 through the U.S. Department of Energy under contract No. DE-AC03-76SF00098.

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  1. Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, California and Genome Sciences Department, Lawrence Berkeley National Laboratory, One Cyclotron Road, Berkeley, California 94720, USA

    Len A. Pennacchio

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Pennacchio, L.A. Insights from human/mouse genome comparisons . Mamm Genome 14, 429–436 (2003). https://doi.org/10.1007/s00335-002-4001-1

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