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Association found between the promoter region polymorphism in the apolipoprotein A-V gene and the serum triglyceride level in Japanese schoolchildren

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Abstract.

The purpose of this study was to assess the influence of single nucleotide polymorphism 3 (SNP3) of the apolipoprotein A-V (APOA5) gene on the serum triglyceride (TG) level in Japanese schoolchildren. To determine the frequency of the genotype, we analyzed 552 schoolchildren. The frequencies of the T/T, T/C and C/C genotypes of the APOA5 gene were 225 (40.8%), 263 (47.6%) and 64 (11.6%), respectively. The serum TG level was significantly different among the genotypic groups after adjustments for age, gender and obesity index (T/T 71.6±34.8 mg/dl, T/C 80.7±36.1 mg/dl, C/C 94.4±69.4 mg/dl, P<0.0001). The odds ratio (95% confidence interval) for hypertriglyceridemia of the C allele was 2.4 (1.0–6.2). Our data suggested that the T/C promoter region polymorphism of the APOA5 gene appears to be a genetic risk factor for hypertriglyceridemia in Japanese children.

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Authors and Affiliations

  1. Department of Medical Science and Welfare, Institute of Community Medicine, University of Tsukuba, Tennoudai 1-1-1, Tsukuba-shi, Ibaraki-ken 305-8575, Japan, , , , ,

    Kazue Endo, Hisako Yanagi, Jungo Araki & Shigeo Tomura

  2. Tsukuba International University, Ibaraki, Japan, , , , ,

    Chiaki Hirano

  3. Department of Medical Genetics, Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki, Japan, , , , ,

    Kimiko Yamakawa-Kobayashi

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  1. Kazue Endo
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  2. Hisako Yanagi
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  3. Jungo Araki
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  4. Chiaki Hirano
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  5. Kimiko Yamakawa-Kobayashi
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  6. Shigeo Tomura
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Endo, K., Yanagi, H., Araki, J. et al. Association found between the promoter region polymorphism in the apolipoprotein A-V gene and the serum triglyceride level in Japanese schoolchildren. Hum Genet 111, 570–572 (2002). https://doi.org/10.1007/s00439-002-0825-0

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  • DOI: https://doi.org/10.1007/s00439-002-0825-0

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