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Regional cerebral blood flow and blood volume in patients with subcortical arteriosclerotic encephalopathy (SAE)

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Abstract

The aim of the present study was a detailed analysis of the regional cerebral blood flow and blood volume in patients with subcortical arteriosclerotic encephalopathy (SAE) by means of functional magnetic resonance imaging (MRI). A group of 26 patients with SAE and a group of 16 age-matched healthy volunteers were examined. Using a well-established dynamic susceptibility contrast-enhanced MRI method, the regional cerebral blood flow (rCBF) and blood volume (rCBV) were quantified for each subject in 12 different regions in the brain parenchyma. As compared to healthy volunteers, patients with SAE showed significantly reduced rCBF and rCBV values in white matter regions and in the occipital cortex. Regions containing predominantly grey matter show almost normal rCBF and rCBV values. In conclusion, quantitative analysis of rCBF and rCBV values demonstrates clearly that SAE is a disease that is associated with a reduced microcirculation predominantly in white matter.

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Authors and Affiliations

  1. Institut für Klinische Radiologie, Universitätsklinik Mannheim, der Universität Heidelberg, Lauertstr.23, D-69242, Mühlhausen, Germany

    Friedemann J. Gückel, Christine Ueltzhöffer & Wolfgang Neff

  2. Bundesamt für Strahlenschutz, Oberschleißheim, Germany

    Gunnar Brix & Robert Lucht

  3. Neurologische Klinik, Universitätsklinik Mannheim, Mannheim, Germany

    Michael Hennerici

Authors
  1. Friedemann J. Gückel
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  2. Gunnar Brix
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  3. Michael Hennerici
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  4. Robert Lucht
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  5. Christine Ueltzhöffer
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  6. Wolfgang Neff
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Correspondence to Friedemann J. Gückel.

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Gückel, F.J., Brix, G., Hennerici, M. et al. Regional cerebral blood flow and blood volume in patients with subcortical arteriosclerotic encephalopathy (SAE). Eur Radiol 17, 2483–2490 (2007). https://doi.org/10.1007/s00330-007-0617-y

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