Abstract
We studied whether dynamic contrast-enhanced MRI (DCE-MRI) could identify histopathological characteristics of breast cancer. Seventy-five patients with breast cancer underwent DCE-MRI followed by core biopsy. DCE-MRI findings were evaluated following the scoring system published by Fischer in 1999. In this scoring system, five DCE-MRI features, three morphological (shape, margins, enhancement kinetic) and two functional (initial peak of signal intensity (SI) increase and behavior of signal intensity curve), are defined by 14 parameters. Each parameter is assigned points ranging from 0 to 1 or 0 to 2, with higher points for those that are more likely to be associated with malignancy. The sum of all the points defines the degree of suspicion of malignancy, with a score 0 representing the lowest and 8 the highest degree of suspicion. Associations between DCE-MRI features and tumor histopathological characteristics assessed on core biopsies (histological type, grading, estrogen and progesterone receptor status, Ki67 and HER2 status) were studied by contingency tables and logistic regression analysis. We found a significant inverse association between the Fischer’s score and HER2-overexpression (odds ratio-OR 0.608, p = 0.02). Based on our results, we suggest that lesions with intermediate-low suspicious DCE-MRI parameters may represent a subset of tumor with poor histopathological characteristics.
Similar content being viewed by others
References
Sardanelli F, Lozzelli A, Fausto A (2003) MR imaging of the breast: indications, established technique, and new directions. Eur Radiol 13(Suppl 3):N28–N36
Esserman L, Hylton N, George T, Weidner N (1999) Contrast-Enhanced Magnetic Resonance Imaging to Assess Tumor Histopathology and Angiogenesis in Breast Carcinoma. Breast J 5:13–21
Esserman L, Hylton N, Yassa L, Barclay J, Frankel S, Sickles E (1999) Utility of magnetic resonance imaging in the management of breast cancer: evidence for improved preoperative staging. J Clin Oncol 17:110–119
Szabo BK, Aspelin P, Kristoffersen WM, Tot T, Bone B (2003) Invasive breast cancer: correlation of dynamic MR features with prognostic factors. Eur Radiol 13:2425–2435 DOI 10.1007/s00330-003-2000-y
Szabo BK, Aspelin P, Wiberg MK, Bone B (2003) Dynamic MR imaging of the breast. Analysis of kinetic and morphologic diagnostic criteria. Acta Radiol 44:379–386
Montemurro F, Martincich L, De Rosa G et al (2005) Dynamic contrast-enhanced MRI and sonography in patients receiving primary chemotherapy for breast cancer. Eur Radiol 15:1224–1234 DOI 10.1007/s00330-005-2656-6
Martincich L, Montemurro F, De Rosa G et al (2004) Monitoring response to primary chemotherapy in breast cancer using dynamic contrast-enhanced magnetic resonance imaging. Breast Cancer Res Treat 83:67–76
Rieber A, Brambs HJ, Gabelmann A, Heilmann V, Kreienberg R, Kuhn T (2002) Breast MRI for monitoring response of primary breast cancer to neo-adjuvant chemotherapy. Eur Radiol 12:1711–1712 DOI 10.1007/s00330-001-1233-x
Abraham DC, Jones RC, Jones SE et al (1996) Evaluation of neoadjuvant chemotherapeutic response of locally advanced breast cancer by magnetic resonance imaging. Cancer 78:91–100
Morakkabati-Spitz N, Leutner C, Schild H, Traeber F, Kuhl C (2005) Diagnostic usefulness of segmental and linear enhancement in dynamic breast MRI. Eur Radiol 15:2010–2011 DOI 10.1007/s00330-005-2755-4
Hawighorst H, Libicher M, Knopp MV, Moehler T, Kauffmann GW, Kaick G (1999) Evaluation of angiogenesis and perfusion of bone marrow lesions: role of semiquantitative and quantitative dynamic MRI. J Magn Reson Imaging 10:286–294
Hayes C, Padhani AR, Leach MO (2002) Assessing changes in tumour vascular function using dynamic contrast-enhanced magnetic resonance imaging. NMR Biomed 15:154–163
Furman-Haran E, Schechtman E, Kelcz F, Kirshenbaum K, Degani H (2005) Magnetic resonance imaging reveals functional diversity of the vasculature in benign and malignant breast lesions. Cancer 104:708–718 DOI 10.1002/cncr.21225
Preda A, Novikov V, Moglich M et al (2005) Magnetic resonance characterization of tumor microvessels in experimental breast tumors using a slow clearance blood pool contrast agent (carboxymethyldextran-A2-Gd-DOTA) with histopathological correlation. Eur Radiol 15:2268–2278 DOI 10.1007/s00330-005-2823-9
Fischer U, Kopka L, Grabbe E (1999) Breast carcinoma: effect of preoperative contrast-enhanced MR imaging on the therapeutic approach. Radiology 213:881–888
Malich A, Fischer DR, Wurdinger S, Boettcher J, Marx C, Facius M, Kaiser WA (2005) Potential MRI interpretation model: differentiation of benign from malignant breast masses. AJR Am J Roentgenol 185:964–970 http://dx.doi.org/10.2214/AJR.04.1073
Goldhirsch A, Glick JH, Gelber RD, Coates AS, Thurlimann B, Senn HJ (2005) Meeting highlights: international expert consensus on the primary therapy of early breast cancer 2005. Ann Oncol 16:1569–1583 http://dx.doi.org/10.1093/annonc/mdi
Montemurro F, Redana S, Valabrega G, Aglietta M (2005) Controversies in breast cancer: adjuvant and neoadjuvant therapy. Expert Opin Pharmacother 6:1055–1072 http://dx.doi.org/10.1517/14656566.6.7.1055
Piccart-Gebhart MJ, Procter M, Leyland-Jones B et al (2005) Trastuzumab after Adjuvant Chemotherapy in HER2-Positive Breast Cancer. N Engl J Med 353:1659–1672 http://dx.doi.org/10.1056/NEJMoa052306
Romond EH, Perez EA, Bryant J et al (2005) Trastuzumab plus Adjuvant Chemotherapy for Operable HER2-Positive Breast Cancer. N Engl J Med 353:1673–1684 http://dx.doi.org/10.1056/NEJMoa052122
Cheung YC, Chen SC, Su MY et al (2003) Monitoring the size and response of locally advanced breast cancers to neoadjuvant chemotherapy (weekly paclitaxel and epirubicin) with serial enhanced MRI. Breast Cancer Res Treat 78:51–58
Ellis CW (1987) Grading of invasive carcinoma of the breast. In: Page DL, Anderson TJ (eds) Diagnostic histopathology of the breast. Churchill Livingstone, Edinburgh, pp 311–330
Slamon DJ, Clark GM, Wong SG, Levin WJ, Ullrich A, McGuire WL (1987) Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science 235:177–182
Kaas R, Kroger R, Hendriks JKCL et al (2004) The signifiance of circumscribed malignant mammographic masses in the surveillance of BRCA 1/2 gene mutation carriers. Eur Radiol 14:1647–1653 http://dx.doi.org/10.1007/s00330-004-2307-3
Tabar L, Tony Chen HH, Amy Yen MF et al (2004) Mammographic tumor features can predict long-term outcomes reliably in women with 1–14-mm invasive breast carcinoma. Cancer 101:1745–1759
Tofts PS, Berkowitz B, Schnall MD (1995) Quantitative analysis of dynamic Gd-DTPA enhancement in breast tumors using a permeability model. Magn Reson Med 33:564–568
Knopp MV, von Tengg-Kobligk H, Choyke PL (2003) Functional magnetic resonance imaging in oncology for diagnosis and therapy monitoring. Mol Cancer Ther 2:419–426
Stoutjesdijk MJ, Futterer JJ, Boetes C, van Die LE, Jager G, Barentsz JO (2005) Variability in the description of morphologic and contrast enhancement characteristics of breast lesions on magnetic resonance imaging. Invest Radiol 40:355–362
Cahill RA, Walsh D, Landers RJ, Watson RG (2006) Preoperative profiling of symptomatic breast cancer by diagnostic core biopsy. Ann Surg Oncol 13:45–51 http://dx.doi.org/10.1245/ASO.2006.03.047
Burge CN, Chang HR, Apple SK (2006) Do the histologic features and results of breast cancer biomarker studies differ between core biopsy and surgical excision specimens? Breast 15:167–172 http://dx./doi.org/10.1016/j.breast.2005.06.004
Usami S, Moriya T, Kasajima A, Suzuki A, Ishida T, Sasano H, Ohuchi N (2005) Pathological aspects of core needle biopsy for non-palpable breast lesions. Breast Cancer 12:272–278 http://dx.doi.org/10.2325/jbcs.12.272
Harris GC, Denley HE, Pinder SE, Lee AH, Ellis IO, Elston CW, Evans A (2003) Correlation of histologic prognostic factors in core biopsies and therapeutic excisions of invasive breast carcinoma. Am J Surg Pathol 27:11–15
Mussurakis S, Buckley DL, Horsman A (1997) Dynamic MR imaging of invasive breast cancer: correlation with tumour grade and other histological factors. Br J Radiol 70:446–451
Matsubayashi R, Matsuo Y, Edakuni G, Satoh T, Tokunaga O, Kudo S (2000) Breast masses with peripheral rim enhancement on dynamic contrast-enhanced MR images: correlation of MR findings with histologic features and expression of growth factors. Radiology 217:841–848
Tuncbilek N, Karakas HM, Okten OO (2005) Dynamic magnetic resonance imaging in determining histopathological prognostic factors of invasive breast cancers. Eur J Radiol 53:199–205 http://dx.doi.org/10.1016/j.ejrad.2004.04.012
Fischer DR, Wurdinger S, Boettcher J, Malich A, Kaiser WA (2005) Further signs in the evaluation of magnetic resonance mammography: a retrospective study. Invest Radiol 40:430–435
Kuhl CK, Kuhn W, Schild H (2005) Management of women at high risk for breast cancer: new imaging beyond mammography. Breast 14:480–486 http://dx.doi.org/10.1016/j.breast.2005.08.005
Artemov D, Mori N, Ravi R, Bhujwalla ZM (2003) Magnetic resonance molecular imaging of the HER-2/neu receptor. Cancer Res 63:2723–2727
Artemov D, Mori N, Okollie B, Bhujwalla ZM (2003) MR molecular imaging of the Her-2/neu receptor in breast cancer cells using targeted iron oxide nanoparticles. Magn Reson Med 49:403–408 http://dx.doi.org/10.1002/mrm.10406
Author information
Authors and Affiliations
Corresponding author
Additional information
Filippo Montemurro and Laura Martincich contributed equally to this work.
Rights and permissions
About this article
Cite this article
Montemurro, F., Martincich, L., Sarotto, I. et al. Relationship between DCE-MRI morphological and functional features and histopathological characteristics of breast cancer. Eur Radiol 17, 1490–1497 (2007). https://doi.org/10.1007/s00330-006-0505-x
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00330-006-0505-x