Skip to main content
SpringerLink
Log in

Hepatocellular adenoma: findings at state-of-the-art magnetic resonance imaging, ultrasound, computed tomography and pathologic analysis

  • Hepatobiliary-Pancreas
  • Published:
European Radiology Aims and scope Submit manuscript

Abstract

The purpose of this paper is to describe the most recent concepts and pertinent findings of hepatocellular adenomas, including clinical presentation, gross pathology and histology, pathogenesis and transformation into hepatocellular carcinoma (HCC), and imaging findings at ultrasound (US), computed tomography (CT), and magnetic resonance (MR) imaging.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7
Fig. 8
Fig. 9
Fig. 10
Fig. 11
Fig. 12
Fig. 13
Fig. 14
Fig. 15

Similar content being viewed by others

References

  1. Baum JK, Bookstein JJ, Holtz F, Klein EW (1973) Possible association between benign hepatomas and oral contraceptives. Lancet 2:926–929

    Article  PubMed  CAS  Google Scholar 

  2. Edmondson H (1958) Tumors of the liver and intrahepatic bile ducts. In: FIo WDA (ed) Pathology. Atlas of tumor pathology. Washington, DC

  3. Edmondson HA, Henderson B, Benton B (1976) Liver-cell adenomas associated with use of oral contraceptives. N Engl J Med 294:470–472

    Article  PubMed  CAS  Google Scholar 

  4. Rooks JB, Ory HW, Ishak KG et al (1979) Epidemiology of hepatocellular adenoma. The role of oral contraceptive use. JAMA 242:644–648

    Article  PubMed  CAS  Google Scholar 

  5. Lindgren A, Olsson R (1993) Liver damage from low-dose oral contraceptives. J Intern Med 234:287–292

    Article  PubMed  CAS  Google Scholar 

  6. Mamada Y, Onda M, Tajiri T et al (2001) Liver cell adenoma in a 26-year-old man. J Nippon Med Sch 68:516–519

    Article  PubMed  CAS  Google Scholar 

  7. Psatha EA, Semelka RC, Armao D, Woosley JT, Firat Z, Schneider G (2005) Hepatocellular adenomas in men: MRI findings in four patients. J Magn Reson Imaging 22:258–264

    Article  PubMed  Google Scholar 

  8. Terkivatan T, de Wilt JH, de Man RA et al (2001) Indications and long-term outcome of treatment for benign hepatic tumors: a critical appraisal. Arch Surg 136:1033–1038

    Article  PubMed  CAS  Google Scholar 

  9. Terminology of nodular hepatocellular lesions (1995) International working party. Hepatology 22:983–993

    Google Scholar 

  10. Anthony P (2002) Tumours and tumour-like lesions of the liver and biliary tract: aetiology, epidemiology and pathology. In: MacSween RNM BA, Portmann BC (eds) Pathology of the liver. Churchill Livingstone, pp 711–775

  11. Goodman ZD, Mikel UV, Lubbers PR, Ros PR, Langloss JM, Ishak KG (1987) Kupffer cells in hepatocellular adenomas. Am J Surg Pathol 11:191–196

    Article  PubMed  CAS  Google Scholar 

  12. Prasad SR, Wang H, Rosas H et al (2005) Fat-containing lesions of the liver: radiologic–pathologic correlation. Radiographics 25:321–331

    Article  PubMed  Google Scholar 

  13. Hussain SM, Semelka RC, Mitchell DG (2002) MR imaging of hepatocellular carcinoma. Magn Reson Imaging Clin N Am 10:31–52, v

    Article  PubMed  Google Scholar 

  14. Lepreux S, Laurent C, Blanc JF et al (2003) The identification of small nodules in liver adenomatosis. J Hepatol 39:77–85

    Article  PubMed  Google Scholar 

  15. Flejou JF, Barge J, Menu Y et al (1985) Liver adenomatosis. An entity distinct from liver adenoma? Gastroenterology 89:1132–1138

    PubMed  CAS  Google Scholar 

  16. Paradis V, Benzekri A, Dargere D et al (2004) Telangiectatic focal nodular hyperplasia: a variant of hepatocellular adenoma. Gastroenterology 126:1323–1329

    Article  PubMed  Google Scholar 

  17. Bioulac-Sage P, Rebouissou S, Sa Cunha A et al (2005) Clinical, morphologic, and molecular features defining so-called telangiectatic focal nodular hyperplasias of the liver. Gastroenterology 128:1211–1218

    Article  PubMed  Google Scholar 

  18. Gordon SC, Reddy KR, Livingstone AS, Jeffers LJ, Schiff ER (1986) Resolution of a contraceptive-steroid-induced hepatic adenoma with subsequent evolution into hepatocellular carcinoma. Ann Intern Med 105:547–549

    PubMed  CAS  Google Scholar 

  19. Gyorffy EJ, Bredfeldt JE, Black WC (1989) Transformation of hepatic cell adenoma to hepatocellular carcinoma due to oral contraceptive use. Ann Intern Med 110:489–490

    PubMed  CAS  Google Scholar 

  20. Tao LC (1991) Oral contraceptive-associated liver cell adenoma and hepatocellular carcinoma. Cytomorphology and mechanism of malignant transformation. Cancer 68:341–347

    Article  PubMed  CAS  Google Scholar 

  21. Ferrell LD (1993) Hepatocellular carcinoma arising in a focus of multilobular adenoma. A case report. Am J Surg Pathol 17:525–529

    Article  PubMed  CAS  Google Scholar 

  22. Foster JH, Berman MM (1994) The malignant transformation of liver cell adenomas. Arch Surg 129:712–717

    PubMed  CAS  Google Scholar 

  23. Hussain SM, Zondervan PE, JN IJ, Schalm SW, de Man RA, Krestin GP (2002) Benign versus malignant hepatic nodules: MR imaging findings with pathologic correlation. Radiographics 22:1023–1036, discussion 1037–1029

    PubMed  Google Scholar 

  24. Welch TJ, Sheedy PF 2nd, Johnson CM et al (1985) Focal nodular hyperplasia and hepatic adenoma: comparison of angiography, CT, US, and scintigraphy. Radiology 156:593–595

    PubMed  CAS  Google Scholar 

  25. Numata K, Tanaka K, Mitsui K, Morimoto M, Inoue S, Yonezawa H (1993) Flow characteristics of hepatic tumors at color Doppler sonography: correlation with arteriographic findings. AJR Am J Roentgenol 160:515–521

    PubMed  CAS  Google Scholar 

  26. Bryant TH, Blomley MJ, Albrecht T et al (2004) Improved characterization of liver lesions with liver-phase uptake of liver-specific microbubbles: prospective multicenter study. Radiology 232:799–809

    Article  PubMed  Google Scholar 

  27. Ichikawa T, Federle MP, Grazioli L, Nalesnik M (2000) Hepatocellular adenoma: multiphasic CT and histopathologic findings in 25 patients. Radiology 214:861–868

    PubMed  CAS  Google Scholar 

  28. Grazioli L, Federle MP, Ichikawa T, Balzano E, Nalesnik M, Madariaga J (2000) Liver adenomatosis: clinical, histopathologic, and imaging findings in 15 patients. Radiology 216:395–402

    PubMed  CAS  Google Scholar 

  29. Paulson EK, McClellan JS, Washington K, Spritzer CE, Meyers WC, Baker ME (1994) Hepatic adenoma: MR characteristics and correlation with pathologic findings. AJR Am J Roentgenol 163:113–116

    PubMed  CAS  Google Scholar 

  30. Arrive L, Flejou JF, Vilgrain V et al (1994) Hepatic adenoma: MR findings in 51 pathologically proved lesions. Radiology 193:507–512

    PubMed  CAS  Google Scholar 

  31. Chung KY, Mayo-Smith WW, Saini S, Rahmouni A, Golli M, Mathieu D (1995) Hepatocellular adenoma: MR imaging features with pathologic correlation. AJR Am J Roentgenol 165:303–308

    PubMed  CAS  Google Scholar 

  32. Mathieu D, Bruneton JN, Drouillard J, Pointreau CC, Vasile N (1986) Hepatic adenomas and focal nodular hyperplasia: dynamic CT study. Radiology 160:53–58

    PubMed  CAS  Google Scholar 

  33. Hussain SM, Semelka RC (2005) Hepatic imaging: comparison of modalities. Radiol Clin North Am 43:929–947, ix

    Article  PubMed  Google Scholar 

  34. Hussain SM, Semelka RC (2005) Liver masses. Magn Reson Imaging Clin N Am 13:255–275

    Article  PubMed  Google Scholar 

  35. Bartolozzi C, Lencioni R, Paolicchi A, Moretti M, Armillotta N, Pinto F (1997) Differentiation of hepatocellular adenoma and focal nodular hyperplasia of the liver: comparison of power Doppler imaging and conventional color Doppler sonography. Eur Radiol 7:1410–1415

    Article  PubMed  CAS  Google Scholar 

  36. Bartolotta TV, Midiri M, Quaia E et al (2005) Benign focal liver lesions: spectrum of findings on SonoVue-enhanced pulse-inversion ultrasonography. Eur Radiol 15:1643–1649

    Article  PubMed  Google Scholar 

  37. Klein D, Jenett M, Gassel HJ, Sandstede J, Hahn D (2004) Quantitative dynamic contrast-enhanced sonography of hepatic tumors. Eur Radiol 14:1082–1091

    Article  PubMed  Google Scholar 

  38. Mahfouz AE, Hamm B, Taupitz M, Wolf KJ (1993) Hypervascular liver lesions: differentiation of focal nodular hyperplasia from malignant tumors with dynamic gadolinium-enhanced MR imaging. Radiology 186:133–138

    PubMed  CAS  Google Scholar 

  39. McFarland EG, Mayo-Smith WW, Saini S, Hahn PF, Goldberg MA, Lee MJ (1994) Hepatic hemangiomas and malignant tumors: improved differentiation with heavily T2-weighted conventional spin-echo MR imaging. Radiology 193:43–47

    PubMed  CAS  Google Scholar 

  40. Mitchell DG, Saini S, Weinreb J et al (1994) Hepatic metastases and cavernous hemangiomas: distinction with standard- and triple-dose gadoteridol-enhanced MR imaging. Radiology 193:49–57

    PubMed  CAS  Google Scholar 

  41. Semelka RC, Martin DR, Balci C, Lance T (2001) Focal liver lesions: comparison of dual-phase CT and multisequence multiplanar MR imaging including dynamic gadolinium enhancement. J Magn Reson Imaging 13:397–401

    Article  PubMed  CAS  Google Scholar 

  42. Hussain SM, Terkivatan T, Zondervan PE et al (2004) Focal nodular hyperplasia: findings at state-of-the-art MR imaging, US, CT, and pathologic analysis. Radiographics 24:3–17, discussion 18–19

    Article  PubMed  Google Scholar 

  43. Attal P, Vilgrain V, Brancatelli G et al (2003) Telangiectatic focal nodular hyperplasia: US, CT, and MR imaging findings with histopathologic correlation in 13 cases. Radiology 228:465–472

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Radiology, Erasmus Medical Center, Rotterdam, The Netherlands

    Shahid M. Hussain, Indra C. van den Bos, Roy S. Dwarkasing & Jan-Willem Kuiper

  2. Department of Pathology, Erasmus Medical Center, Rotterdam, The Netherlands

    Jan den Hollander

  3. Department of Radiology, University of Nebraska Medical Center, Omaha, Nebraska, USA

    Shahid M. Hussain

Authors
  1. Shahid M. Hussain
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Indra C. van den Bos
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Roy S. Dwarkasing
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Jan-Willem Kuiper
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Jan den Hollander
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Shahid M. Hussain.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hussain, S.M., van den Bos, I.C., Dwarkasing, R.S. et al. Hepatocellular adenoma: findings at state-of-the-art magnetic resonance imaging, ultrasound, computed tomography and pathologic analysis. Eur Radiol 16, 1873–1886 (2006). https://doi.org/10.1007/s00330-006-0292-4

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00330-006-0292-4

Keywords

Search

Navigation