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Combined T2* and T1 measurements for improved perfusion and permeability studies in high field using dynamic contrast enhancement

  • Magnetic Resonance
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Abstract

This study analyzed the T2* effect of extracellularly distributed gadolinium contrast agents in arterial blood during tumor studies using T1-weighted sequences at high field strength. A saturation-prepared dual echo sequence with echo times of 1.5 and 3.5 ms was employed at 3 T to simultaneously characterize T1 and T2* of arterial blood during bolus administration of Gd-DTPA in 28 patients with body tumors. T2* effect and T1 effect of Gd-DTPA on image intensity of whole blood were calibrated in human blood samples with different concentrations of contrast agent. T2* was used to estimate concentration near the peak of the bolus. T1 was used to measure lower concentrations when T2* was not significant. T2* was measurable on calibration curves for Gd-DTPA concentrations higher than 4 mM. This concentration was exceeded in 18 patients. The mean signal intensity reduction because of T2* effect was estimated at 22±14% of the T2* compensated signal. Using T2* measurements reduced underestimations of peak arterial Gd-DTPA concentration (59±38%) and overestimation of permeability Ktrans (58%). The T2* effect of gadolinium contrast agents should therefore be accounted for when performing tumors study with T1-weighted sequences at high field strength.

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Authors and Affiliations

  1. Radiology Department, Saint Louis Hospital, 1 avenue Claude Vellefaux, 75475, Paris, Cedex 10, France

    Cedric de Bazelaire

  2. Department of Radiology, Beth Israel Deaconess Medical Center and Harvard Medical School, Cambridge, MA, USA

    Cedric de Bazelaire, Neil M. Rofsky, Guillaume Duhamel, Jingbo Zhang & David C. Alsop

  3. Department of Hematology/Oncology, Massachusetts General Hospital, Boston, MA, USA

    M. Dror Michaelson

  4. Department of Adult Oncology, Dana Farber Cancer Institute, Boston, MA, USA

    Daniel George

Authors
  1. Cedric de Bazelaire
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  2. Neil M. Rofsky
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  3. Guillaume Duhamel
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  4. Jingbo Zhang
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  5. M. Dror Michaelson
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  6. Daniel George
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  7. David C. Alsop
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Correspondence to Cedric de Bazelaire.

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de Bazelaire, C., Rofsky, N.M., Duhamel, G. et al. Combined T2* and T1 measurements for improved perfusion and permeability studies in high field using dynamic contrast enhancement. Eur Radiol 16, 2083–2091 (2006). https://doi.org/10.1007/s00330-006-0198-1

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  • DOI: https://doi.org/10.1007/s00330-006-0198-1

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