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Influence of cardiac hemodynamic parameters on coronary artery opacification with 64-slice computed tomography

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Abstract

The purpose of this study was to evaluate the influence of ejection fraction (EF), stroke volume (SV), heart rate, and cardiac output (CO) on coronary artery opacification with 64-slice computed tomography (CT). Sixty patients underwent, retrospectively, electrocardiography-gated 64-slice CT coronary angiography. Left ventricular EF, SV, and CO were calculated with semi-automated software. Attenuation values were measured and contrast-to-noise ratios (CNRs) were calculated in the proximal right coronary artery (RCA) and left main artery (LMA). Mean EF during scanning was 61.5±12.4%, SV was 63.2±15.6 ml, heart rate was 62.5±11.8 beats per minute (bpm), and CO was 3.88±1.06 l/min. There was no significant correlation between the EF and heart rate and the attenuation and CNR in either coronary artery. A significant negative correlation was found in both arteries between SV and attenuation (RCA r=−0.26, P<0.05; LMA r=−0.34, P<0.01) and between SV and CNR (RCA r=−0.26, P<0.05; LMA r=−0.26, P<0.05). Similarly, a significant negative correlation was found between the CO and attenuation (RCA r=−0.42, P<0.05; LMA r=−0.56, P<0.001) and between the CO and CNR (RCA r=−0.39, P<0.05; LMA r=−0.44, P<0.001). The actual hemodynamic status of the patient influences the coronary artery opacification with 64-slice CT, in that vessel opacification decreases as SV and CO increase.

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Acknowledgment

This research was supported by the National Center of Competence in Research, Computer Aided and Image Guided Medical Interventions (NCCR CO-ME) of the Swiss National Science Foundation.

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Authors and Affiliations

  1. Department of Medical Radiology, Institute of Diagnostic Radiology, University Hospital of Zurich, Raemistrasse 100, 8091, Zurich, Switzerland

    Lars Husmann, Hatem Alkadhi, Thomas Boehm, Sebastian Leschka, Lotus Desbiolles & Borut Marincek

  2. Cardiovascular Center, University Hospital of Zurich, Zurich, Switzerland

    Tiziano Schepis, Pascal Koepfli, Philipp A. Kaufmann & Simon Wildermuth

  3. Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland

    Philipp A. Kaufmann

Authors
  1. Lars Husmann
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  2. Hatem Alkadhi
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  3. Thomas Boehm
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  4. Sebastian Leschka
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  5. Tiziano Schepis
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  6. Pascal Koepfli
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  7. Lotus Desbiolles
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  8. Borut Marincek
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  9. Philipp A. Kaufmann
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  10. Simon Wildermuth
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Correspondence to Hatem Alkadhi.

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Husmann, L., Alkadhi, H., Boehm, T. et al. Influence of cardiac hemodynamic parameters on coronary artery opacification with 64-slice computed tomography. Eur Radiol 16, 1111–1116 (2006). https://doi.org/10.1007/s00330-005-0110-4

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  • DOI: https://doi.org/10.1007/s00330-005-0110-4

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