Skip to main content

Advertisement

SpringerLink
Log in

Impact of hybrid molecular imaging in retroperitoneal fibrosis: a systematic review

  • Imaging
  • Published:
Rheumatology International Aims and scope Submit manuscript

Abstract

The aim of this article was to critically assess the usefulness of hybrid molecular imaging (FDG PET/CT and FDG PET/MR) procedures in the evaluation of inflammatory activity in retroperitoneal fibrosis (RPF). A systematic review of the literature was performed using PubMed without timeline restriction and using the following keywords: retroperitoneal fibrosis, disease activity, diagnostic techniques, PET/CT, PET/MR. We evaluated full text articles written in the English language. Case reports, review articles or editorials and articles not in the field of interest of this review were excluded. Nine articles comprising a total of 186 patients met the inclusion criteria and were included and described in this systematic review. The new hybrid molecular imaging methods give promising results in the evaluation of the activity of the disease, quantification and prediction of therapeutic response and in tailoring medical therapy in RPF. FDG PET/CT can be a valuable tool in detecting disease activity, particularly in asymptomatic patients with RPF with acute phase reactant increase. Hybrid imaging can predict therapy response outcome and the best time for stent removal. Although PET/MR has potential advantage in small lesions and has reduced radiation exposure in comparison to PET/CT, PET quantification parameters have potentially higher diagnostic value over MR parameters in the evaluation of RPF. Acute phase reactants alone may not be reliable for the management and follow-up assessment of the disease. Hybrid imaging in RFP could be more comfortable, more accurate, with less radiation burden than different separate imaging studies acquired at different points in time.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

References

  1. VaglioA Salvarani C, Buzio C (2006) Retroperitoneal fibrosis. Lancet 367(9506):241–251

    Article  Google Scholar 

  2. Palmisano A, Vaglio A (2009) Chronic periaortitis: a fibro-inflammatory disorder. Best Pract Res 23(3):339–353

    Article  Google Scholar 

  3. Pipitone N, Salvarani C, Peter HH (2010) Chronic periaortitis. Internist 51:45–52

    Article  CAS  PubMed  Google Scholar 

  4. Otomi Y, Otsuka H, Terazawa K, Nose H, Kubo M, Yoneda K, Kitsukawa K, Harada M (2013) (18)F-2-fluoro-2-deoxyglucose uptake in or adjacent to blood vessel walls. J Med Invest 60(1–2):15–20

    Article  PubMed  Google Scholar 

  5. Yilmaz S, Tanb YZ, Ozhan M, Halac M, Asa S, Sönmezoglu K (2012) FDG PET/CT in monitoring treatment of retroperitoneal fibrosis. Rev Esp Med Nucl Imagen Mol 31(6):338–339

    CAS  PubMed  Google Scholar 

  6. Lepor H, Walsh PC (1979) Idiopathic retroperitoneal fibrosis. J Urol 122(1):1–6

    Article  CAS  PubMed  Google Scholar 

  7. Mehta A, Blodgett MT (2011) Retroperitoneal Fibrosis as a cause of positive FDG PET/CT. J Radiol Case Reports 5(7):35–41

    Article  Google Scholar 

  8. Van Bommel EF, Siemes C, Hak LE, van der Veer SJ, Hendriksz TR (2007) Long-term renal and patient outcome in idiopathic retroperitoneal fibrosis treated with prednisone. Am J Kidney Dis 49(5):615–625

    Article  PubMed  Google Scholar 

  9. Monev S (2002) Idiopathic retroperitoneal fibrosis:prompt diagnosis preserves organ function. Cleve Clin J Med 69:160–166

    Article  PubMed  Google Scholar 

  10. Bertagna F, Treglia G, Leccisotti L (2012) [18F]FDG-PET/CT in patients affected by retroperitoneal fibrosis: a bicentric experience. Jpn J Radiol 30:415–421

    Article  PubMed  Google Scholar 

  11. Kottra JJ, Dunnick NR (1996) Retroperitoneal fibrosis. Radiol Clin North Am 43:1259–1275

    Google Scholar 

  12. Talati SJ, Abghari R, Kochkodan JJ, Helmer SR (1995) Use of Ga-67 imaging in diagnosis and follow-up after steroid treatment of retroperitoneal fibrosis. Clin Nucl Med 20:995–997

    Article  CAS  PubMed  Google Scholar 

  13. Treglia G, Mattoli MV, Bertagna F, Giubbini R, Giordano A (2013) Emerging role of Fluorine-18-fluorodeoxy glucose positron emission tomography in patients with retroperitoneal fibrosis: a systematic review. Rheumatol Int 33:549–555

    Article  PubMed  Google Scholar 

  14. Nakajo M, Jinnouchi S, Tanabe H, Tateno R, Nakajo M (2007) 18F-fluoro deoxyglucose positron emission tomography features of idiopathic retroperitoneal fibrosis. J Comput Assist Tomogr 31(4):539–543

    Article  PubMed  Google Scholar 

  15. Piccoli GB, ConsiglioV Arena V, Pelosi E, Anastasios D, Ragni F, Fiori C, Cortese G, Deagostini MC, Porpiglia F, Scarpa RM (2010) Positron emission tomography as a tool for the‘tailored’management of retroperitoneal fibrosis: a nephro-urological experience. Nephrol Dial Transpl 25(8):2603–2610

    Article  Google Scholar 

  16. Guignard R, Simukoniene M, Garibotto V, Ratib O (2012) 18F-FDG PET/CT and contrast-enhanced CT in a one-stop diagnostic procedure: a better strategy for management of patients suffering from retroperitoneal fibrosis? Clin Nucl Med 37(5):453–459

    Article  PubMed  Google Scholar 

  17. Moroni G, Castellani M, Balzani A, Dore R, Bonelli N, Longhi S, Martinelli I, Messa P, Gerundini P (2012) The value of 18FFDG PET/CT in the assessment of active idiopathic retroperitoneal fibrosis. Eur J Nucl Med Mol Imaging 39:1635–1642

    Article  PubMed  Google Scholar 

  18. Fofi C, Prosperi D, Pettorini L, Festuccia F, Pirisino R, Lanni V, Scopinaro F, Punzo G, Menè P (2016) Diagnosis and follow-up of idiopathic retroperitoneal fibrosis: role of (18)F-FDG-PET/CT and biochemical parameters in patients with renal involvement. Intern Emerg Med 11(6):809–816

    Article  PubMed  Google Scholar 

  19. Ruhlmann V, Poeppel TD, Brandt AS, Grüneisen J, Ruhlmann M, Theysohn JM, Forsting M, Bockisch A, Umutlu L (2016) (18)F-FDG PET/MRI evaluation of retroperitoneal fibrosis: a simultaneous multiparametric approach for diagnosing active disease. Eur J Nucl Med Mol Imaging. 43(9):1646–1652

    Article  CAS  PubMed  Google Scholar 

  20. Fernando A, Pattison J, Horsfield C, D’Cruz D, Cook G, O’Brien T (2016) [18F]-fluorodeoxyglucose positron emission tomography in the diagnosis, treatment stratification, and monitoring of patients with retroperitoneal fibrosis: a prospective clinical study. Eur Urol. doi:10.1016/j.eururo.2016.10.046

    PubMed  Google Scholar 

  21. Thuermel K, Einspieler I, Wolfram S, Moog P, Meier R, Schwaiger M, Heemann U (2017) Disease activity and vascular involvement in retroperitoneal fibrosis: first experience with fully integrated 18F-fluorodeoxyglucose positron emission tomography/magnetic resonance imaging compared to clinical and laboratory parameters. Clin Exp Rheumatol 35 Suppl 103(1):146–154

    PubMed  Google Scholar 

  22. Brix G, Lechel U, Glatting G, Ziegler SI, Münzing W, Müller SP, Beyer T (2005) Radiation exposure of patients undergoing whole-body dual-modality 18F-FDG PET/CT examinations. J Nucl Med 46(4):608–613

    CAS  PubMed  Google Scholar 

  23. Tonkopi E, Ross AA, MacDonald A (2013) Journal club: CT dose optimization for whole-body PET/CT examinations. AJR Am J Roentgenol 201(2):257–263

    Article  PubMed  Google Scholar 

  24. Veenstra DL, Best JH, Hornberger J, Sullivan SD, Hricik DE (1999) Incidence and long-term cost of steroid-related side effects after renal transplantation. Am J Kidney Dis 33(5):829–839

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Center for Nuclear Medicine, Clinical Center of Serbia, University of Belgrade, Visegradska 26, Belgrade, 11000, Serbia

    Isidora T. Grozdic Milojevic, Dragana P. Sobic-Saranovic & Vera M. Artiko

  2. Clinic of Urology, Clinical Center of Serbia, University of Belgrade, Belgrade, Serbia

    Bogomir Milojevic

  3. Faculty of Medicine, University of Belgrade, Belgrade, Serbia

    Isidora T. Grozdic Milojevic, Dragana P. Sobic-Saranovic & Vera M. Artiko

Authors
  1. Isidora T. Grozdic Milojevic
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Bogomir Milojevic
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Dragana P. Sobic-Saranovic
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Vera M. Artiko
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Isidora T. Grozdic Milojevic.

Ethics declarations

Funding

No funding was received for the study.

Conflict of interest

Isidora T. Grozdic Milojevic, Bogomir Milojevic, Dragana P.Sobic-Saranovic and Vera M.Artiko declare that they have no conflict of interest.

Ethical approval

For this type of retrospective study formal consent is not required.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Grozdic Milojevic, I.T., Milojevic, B., Sobic-Saranovic, D.P. et al. Impact of hybrid molecular imaging in retroperitoneal fibrosis: a systematic review. Rheumatol Int 38, 179–187 (2018). https://doi.org/10.1007/s00296-017-3798-y

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00296-017-3798-y

Keywords

Search

Navigation