Skip to main content

Advertisement

Log in

Prevalence and incidence of gout in Korea: data from the national health claims database 2007–2015

  • Epidemiology of RMD
  • Published:
Rheumatology International Aims and scope Submit manuscript

Abstract

The purpose of the present study was to investigate the prevalence and incidence of gout in Korea and predict the future prevalence and incidence of gout. Data were collected from the national health claims database. Patients who had at least one claim for gout between 2007 and 2015 were included in the study. The prevalence of gout from 2007 to 2015 and the incidence of gout from 2009 to 2015 were determined. We estimated sex- and age-specific prevalence and incidence of gout during the period. The prevalence and incidence of gout were predicted using time series analysis. The prevalence of gout (95% CI) increased from 3.49 (3.48–3.51) per 1000 persons in 2007 to 7.58 (7.55–7.60) per 1000 persons in 2015. The incidence of gout (95% CI) was 1.52 (1.51–1.53) in 2009 and rose to 1.94 (1.93–1.95) per 1000 persons in 2015. The prevalence and incidence of gout were higher in men than in women. The older population had a higher prevalence and incidence than the younger population. The increase in prevalence was higher in the older population than the younger population, whereas the increase in incidence was higher in the younger population than the older population. The predicted prevalence and incidence of gout (95% CI) in 2025 were 16.59 (15.85–17.34) per 1000 persons and 3.81 (3.14–4.47) per 1000 persons. The prevalence and incidence of gout increased in Korea between 2007 and 2015. Men and the older population had a higher prevalence and incidence of gout compared to women and the younger population. However, the incidence of gout in the younger population has increased rapidly in recent years.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

References

  1. Riedel AA, Nelson M, Wallace K, Joseph-Ridge N, Cleary M, Fam AG (2004) Prevalence of comorbid conditions and prescription medication use among patients with gout and hyperuricemia in a managed care setting. J Clin Rheumatol 10(6):308–314. doi:10.1097/01.rhu.0000147049.12220.32

    Article  PubMed  Google Scholar 

  2. Rho YH, Choi SJ, Lee YH, Ji JD, Choi KM, Baik SH, Chung SH, Kim CG, Choe JY, Lee SW, Chung WT, Song GG (2005) The prevalence of metabolic syndrome in patients with gout: a multicenter study. J Korean Med Sci 20(6):1029–1033. doi:10.3346/jkms.2005.20.6.1029

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Janssens HJ, Arts PG, Schalk BW, Biermans MC (2016) Gout and rheumatoid arthritis, both to keep in mind in cardiovascular risk management: a primary care retrospective cohort study. Joint Bone Spine. doi:10.1016/j.jbspin.2015.12.003

    Google Scholar 

  4. Chou CT, Lai JS (1998) The epidemiology of hyperuricaemia and gout in Taiwan aborigines. Br J Rheumatol 37(3):258–262

    Article  CAS  PubMed  Google Scholar 

  5. Tu FY, Lin GT, Lee SS, Tung YC, Tu HP, Chiang HC (2015) Prevalence of gout with comorbidity aggregations in southern Taiwan. Joint Bone Spine 82(1):45–51. doi:10.1016/j.jbspin.2014.07.002

    Article  PubMed  Google Scholar 

  6. Klemp P, Stansfield SA, Castle B, Robertson MC (1997) Gout is on the increase in New Zealand. Ann Rheum Dis 56(1):22–26

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Zhu Y, Pandya BJ, Choi HK (2011) Prevalence of gout and hyperuricemia in the US general population: the National Health and Nutrition Examination Survey 2007–2008. Arthritis Rheum 63(10):3136–3141. doi:10.1002/art.30520

    Article  PubMed  Google Scholar 

  8. Kuo CF, Grainge MJ, Mallen C, Zhang W, Doherty M (2015) Rising burden of gout in the UK but continuing suboptimal management: a nationwide population study. Ann Rheum Dis 74(4):661–667. doi:10.1136/annrheumdis-2013-204463

    Article  PubMed  Google Scholar 

  9. Nan H, Qiao Q, Dong Y, Gao W, Tang B, Qian R, Tuomilehto J (2006) The prevalence of hyperuricemia in a population of the coastal city of Qingdao, China. J Rheumatol 33(7):1346–1350

    PubMed  Google Scholar 

  10. Miao Z, Li C, Chen Y, Zhao S, Wang Y, Wang Z, Chen X, Xu F, Wang F, Sun R, Hu J, Song W, Yan S, Wang CY (2008) Dietary and lifestyle changes associated with high prevalence of hyperuricemia and gout in the Shandong coastal cities of Eastern China. J Rheumatol 35(9):1859–1864

    PubMed  Google Scholar 

  11. Arromdee E, Michet CJ, Crowson CS, O’Fallon WM, Gabriel SE (2002) Epidemiology of gout: is the incidence rising? J Rheumatol 29(11):2403–2406

    PubMed  Google Scholar 

  12. Kuo CF, Grainge MJ, See LC, Yu KH, Luo SF, Zhang W, Doherty M (2015) Epidemiology and management of gout in Taiwan: a nationwide population study. Arthritis Res Ther 17:13. doi:10.1186/s13075-015-0522-8

    Article  PubMed  PubMed Central  Google Scholar 

  13. Kim EH, Jeon K, Park KW, Kim HJ, Ahn JK, Jeon CH, Cha H-S, Koh E-M (2004) The prevalence of gout among hyperuricemic population (the prevalence of gout among hyperuricemic population). J Rheum Dis 11(1):7–13

    Google Scholar 

  14. Lee CH, Sung NY (2011) The prevalence and features of Korean gout patients using the National Health Insurance Corporation database. J Rheum Dis 18(2):94–100

    Article  Google Scholar 

  15. Koo BK, Lee CH, Yang BR, Hwang SS, Choi NK (2014) The incidence and prevalence of diabetes mellitus and related atherosclerotic complications in Korea: a National Health Insurance Database Study. PLoS One 9(10):e110650. doi:10.1371/journal.pone.0110650

    Article  PubMed  PubMed Central  Google Scholar 

  16. Shim JS, Sung YK, Joo YB, Lee HS, Bae SC (2014) Prevalence and incidence of systemic lupus erythematosus in South Korea. Rheumatol Int 34(7):909–917. doi:10.1007/s00296-013-2915-9

    Article  PubMed  Google Scholar 

  17. Park SJ, Kwon KE, Choi NK, Park KH, Woo SJ (2015) Prevalence and incidence of exudative age-related macular degeneration in South Korea: a nationwide population-based study. Ophthalmology 122(10):2063–2070.e2061. doi:10.1016/j.ophtha.2015.06.018

  18. Trifiro G, Morabito P, Cavagna L, Ferrajolo C, Pecchioli S, Simonetti M, Bianchini E, Medea G, Cricelli C, Caputi AP, Mazzaglia G (2013) Epidemiology of gout and hyperuricaemia in Italy during the years 2005–2009: a nationwide population-based study. Ann Rheum Dis 72(5):694–700. doi:10.1136/annrheumdis-2011-201254

    Article  CAS  PubMed  Google Scholar 

  19. Bardin T, Bouée S, Clerson P, Chalès G, Flipo RM, Lioté F, Perez V, Poiraud T, Schaeverbeke T, Richette P (2016) Prevalence of gout in the adult population of France. Arthritis Care Res 68(2):261–266

    Article  Google Scholar 

  20. Teng GG, Ang LW, Saag KG, Yu MC, Yuan JM, Koh WP (2012) Mortality due to coronary heart disease and kidney disease among middle-aged and elderly men and women with gout in the Singapore Chinese Health Study. Ann Rheum Dis 71(6):924–928. doi:10.1136/ard.2011.200523

    Article  PubMed  Google Scholar 

  21. Kuo CF, Grainge MJ, See LC, Yu KH, Luo SF, Valdes AM, Zhang W, Doherty M (2015) Familial aggregation of gout and relative genetic and environmental contributions: a nationwide population study in Taiwan. Ann Rheum Dis 74(2):369–374. doi:10.1136/annrheumdis-2013-204067

    Article  PubMed  Google Scholar 

  22. Choi HK, Atkinson K, Karlson EW, Willett W, Curhan G (2004) Purine-rich foods, dairy and protein intake, and the risk of gout in men. N Engl J Med 350(11):1093–1103. doi:10.1056/NEJMoa035700

    Article  CAS  PubMed  Google Scholar 

  23. Choi HK, Atkinson K, Karlson EW, Willett W, Curhan G (2004) Alcohol intake and risk of incident gout in men: a prospective study. Lancet 363(9417):1277–1281. doi:10.1016/s0140-6736(04)16000-5

    Article  PubMed  Google Scholar 

  24. Choi HK, Curhan G (2008) Soft drinks, fructose consumption, and the risk of gout in men: prospective cohort study. BMJ 336(7639):309–312. doi:10.1136/bmj.39449.819271.BE

    Article  PubMed  PubMed Central  Google Scholar 

  25. Choi HK, Atkinson K, Karlson EW, Curhan G (2005) Obesity, weight change, hypertension, diuretic use, and risk of gout in men: the health professionals follow-up study. Arch Intern Med 165(7):742–748. doi:10.1001/archinte.165.7.742

    Article  PubMed  Google Scholar 

  26. Bhole V, de Vera M, Rahman MM, Krishnan E, Choi H (2010) Epidemiology of gout in women: fifty-two-year followup of a prospective cohort. Arthritis Rheum 62(4):1069–1076. doi:10.1002/art.27338

    Article  PubMed  Google Scholar 

  27. Saag KG, Choi H (2006) Epidemiology, risk factors, and lifestyle modifications for gout. Arthritis Res Ther 8(Suppl 1):S2. doi:10.1186/ar1907

    Article  PubMed  PubMed Central  Google Scholar 

  28. Adamopoulos D, Vlassopoulos C, Seitanides B, Contoyiannis P, Vassilopoulos P (1977) The relationship of sex steroids to uric acid levels in plasma and urine. Acta Endocrinol (Copenh) 85(1):198–208

    CAS  Google Scholar 

  29. Hak AE, Curhan GC, Grodstein F, Choi HK (2010) Menopause, postmenopausal hormone use and risk of incident gout. Ann Rheum Dis 69(7):1305–1309. doi:10.1136/ard.2009.109884

    Article  PubMed  Google Scholar 

  30. Roubenoff R, Klag MJ, Mead LA, Liang KY, Seidler AJ, Hochberg MC (1991) Incidence and risk factors for gout in white men. JAMA 266(21):3004–3007

    Article  CAS  PubMed  Google Scholar 

  31. Maynard JW, McAdams-DeMarco MA, Law A, Kao L, Gelber AC, Coresh J, Baer AN (2014) Racial differences in gout incidence in a population-based cohort: atherosclerosis Risk in Communities Study. Am J Epidemiol 179(5):576–583. doi:10.1093/aje/kwt299

    Article  PubMed  Google Scholar 

  32. Mikuls TR, Farrar JT, Bilker WB, Fernandes S, Schumacher HR Jr, Saag KG (2005) Gout epidemiology: results from the UK General Practice Research Database, 1990-1999. Ann Rheum Dis 64(2):267–272. doi:10.1136/ard.2004.024091

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  33. Elliot AJ, Cross KW, Fleming DM (2009) Seasonality and trends in the incidence and prevalence of gout in England and Wales 1994-2007. Ann Rheum Dis 68(11):1728–1733. doi:10.1136/ard.2008.096693

    Article  CAS  PubMed  Google Scholar 

  34. Cea Soriano L, Rothenbacher D, Choi HK, Garcia Rodriguez LA (2011) Contemporary epidemiology of gout in the UK general population. Arthritis Res Ther 13(2):R39. doi:10.1186/ar3272

    Article  PubMed  PubMed Central  Google Scholar 

  35. Dehlin M, Drivelegka P, Sigurdardottir V, Svard A, Jacobsson LT (2016) Incidence and prevalence of gout in Western Sweden. Arthritis Res Ther 18:164. doi:10.1186/s13075-016-1062-6

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgements

This work was supported by a grant of the Research Institute of Medical Science, Catholic University of Daegu (2016).

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Sung-Hoon Park.

Ethics declarations

Conflict of interest

Ji-Won Kim, Sang Gyu Kwak, Hwajeong Lee, Seong-Kyu Kim, Jung-Yoon Choe, and Sung-Hoon Park declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. For this type of study, formal consent is not required.

Human and animal rights

This article does not contain any studies with animals performed by any of the authors.

Funding

No external funding was obtained for performing this study.

Electronic supplementary material

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Kim, JW., Kwak, S.G., Lee, H. et al. Prevalence and incidence of gout in Korea: data from the national health claims database 2007–2015. Rheumatol Int 37, 1499–1506 (2017). https://doi.org/10.1007/s00296-017-3768-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00296-017-3768-4

Keywords

Navigation