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The rate of adherence to urate-lowering therapy and associated factors in Chinese gout patients: a cross-sectional study

  • Observational Research
  • Published:
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Abstract

The aim of this study was to assess adherence rate and predictors of non-adherence with urate-lowering therapy (ULT) in Chinese gout patients. A cross-sectional study was administered to 125 gout patients using the Compliance Questionnaire on Rheumatology (CQR) for adherence to ULT. Patients were asked to complete the Treatment Satisfaction Questionnaire for Medication version II, Health Assessment Questionnaire, Confidence in Gout Treatment Questionnaire, Gout Knowledge Questionnaire, Patient Health Questionnaire-9, Generalized Anxiety Disorder-7, and 36-Item Short Form Health Survey. Data were analyzed by independent sample t test, rank sum test, Chi-square analysis as well as binary stepwise logistic regression modeling. The data showed that the rate of adherence (CQR ≥80%) to ULT was 9.6% in our investigated gout patients. Adherence was associated with functional capacity, gout-related knowledge, satisfaction with medication, confidence in gout treatment and mental components summary. Multivariable analysis of binary stepwise logistic regression identified gout-related knowledge and satisfaction of effectiveness with medication was the independent risk factors of medication non-adherence. Patients unaware of gout-related knowledge, or with low satisfaction of effectiveness with medication, were more likely not to adhere to ULT. Non-adherence to ULT among gout patients is exceedingly common, particularly in patients unaware of gout-related knowledge, or with low satisfaction of effectiveness with medication. These findings could help medical personnel develop useful interventions to improve gout patients’ medication adherence.

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Abbreviations

MSU:

Monosodium urate monohydrate

ULT:

Urate-lowering therapy

sUA:

Serum urate

BMI:

Body mass index

WHR:

Waist hip ratio

CQR:

Compliance Questionnaire on Rheumatology

TSQM:

Treatment Satisfaction Questionnaire for Medication

HAQ:

Health Assessment Questionnaire

GKQ:

Gout Knowledge Questionnaire

PHQ-9:

Patient Health Questionnaire-9

GAD-7:

Generalized Anxiety Disorder-7

SF-36:

36-Item Short Form Health Survey

PCS:

Physical component summary

MCS:

Mental component summary

VAS:

Visual analog scale

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Acknowledgements

We thank all researchers involved in this study. We acknowledge Zhanyun Da, Xinhang Zhu, Genkai Guo, and Yunfei Xia for their assistance in this study. This study was supported by grants from the Chinese National Natural Science Foundation (81671616 and 81471603), Jiangsu Provincial Commission of Health and Family Planning Foundation (H201317 and H201623), Science Foundation of Nantong City (MS22016028), and College graduate research and innovation of Jiangsu Province (KYZZ15-0353).

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  1. Rulan Yin and Haixia Cao contributed equally to this work.

Authors and Affiliations

  1. School of Nursing, Nantong University, 19th Qixiu Road, 226001, Nantong, People’s Republic of China

    Rulan Yin, Ting Fu, Qiuxiang Zhang, Lijuan Zhang & Liren Li

  2. Department of Rheumatology, Affiliated Hospital of Nantong University, 20th Xisi Road, 226001, Nantong, People’s Republic of China

    Rulan Yin, Haixia Cao, Ting Fu, Qiuxiang Zhang, Lijuan Zhang & Zhifeng Gu

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  1. Rulan Yin
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  2. Haixia Cao
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Correspondence to Liren Li or Zhifeng Gu.

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Yin, R., Cao, H., Fu, T. et al. The rate of adherence to urate-lowering therapy and associated factors in Chinese gout patients: a cross-sectional study. Rheumatol Int 37, 1187–1194 (2017). https://doi.org/10.1007/s00296-017-3746-x

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